scholarly journals Polyclonal rabbit anti-human ovarian cancer globulins inhibit tumor growth through apoptosis involving the caspase signaling

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Shuang Zhang ◽  
Min Yu ◽  
Hongxin Deng ◽  
Guobo Shen ◽  
Yuquan Wei
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Human Ovarian Cancer ◽  
Inhibit Tumor Growth ◽  
Polyclonal Rabbit

scholarly journals Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer

2007 ◽  
Vol 6 (11) ◽  
pp. 2959-2966 ◽  
Author(s):  
Hung Huynh ◽  
Ching Ching Melissa Teo ◽  
Khee Chee Soo
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Human Ovarian Cancer ◽  
Inhibit Tumor Growth

The ABCs of ovarian cancer immunology: IgA, B cells, and CTLs

2021 ◽  
Vol 6 (57) ◽  
pp. eabh3184
Author(s):  
Andrew Lichtman
Keyword(s):  
Ovarian Cancer ◽  
B Cells ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Tumor Antigens ◽  
Myeloid Cell ◽  
Nonspecific Binding ◽  
Inhibit Tumor Growth ◽  
Ovarian Cancers ◽  
Secreted Factors

Intratumoral B cells in ovarian cancers produce IgA, which binds tumor antigens and inhibit tumor growth through myeloid cell–dependent mechanisms or by neutralization of secreted factors, and by antigen-nonspecific binding to poly-Ig receptor on cancer cells leading to transcytosis, which sensitizes the cells for CTL killing.

scholarly journals Polyclonal Rabbit Anti-Cancer-Associated Fibroblasts Globulins Induce Cancer Cells Apoptosis and Inhibit Tumor Growth

2018 ◽  
Vol 14 (12) ◽  
pp. 1621-1629 ◽  
Author(s):  
Xiuying Li ◽  
Fengchang Huang ◽  
Xiaoyu Xu ◽  
Shuenqin Hu
Keyword(s):  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Associated Fibroblasts ◽  
Inhibit Tumor Growth ◽  
Polyclonal Rabbit ◽  
Anti Cancer

Novel organo-osmium(ii) proteosynthesis inhibitors active against human ovarian cancer cells reduce gonad tumor growth in Caenorhabditis elegans

2021 ◽  
Vol 8 (1) ◽  
pp. 141-155
Author(s):  
Enrique Ortega ◽  
Francisco J. Ballester ◽  
Alba Hernández-García ◽  
Samanta Hernández-García ◽  
M. Alejandra Guerrero-Rubio ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Antitumor Activity ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Arene Complexes ◽  
C Elegans

Novel Os(ii) arene complexes with a deprotonated ppy or ppy-CHO C^N ligand have been synthesized to selectively act on cancer cells as proteosynthesis inhibitors in vitro and exert antitumor activity in vivo in C. elegans models.

scholarly journals NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo

IUBMB Life ◽  
2012 ◽  
Vol 64 (7) ◽  
pp. 636-643 ◽  
Author(s):  
Kristal Duncan ◽  
Henriette Uwimpuhwe ◽  
Akos Czibere ◽  
Devanand Sarkar ◽  
Towia A. Libermann ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Inhibit Tumor Growth

Inhibition of Intraperitoneal Tumor Growth of Human Ovarian Cancer Cells by Bi- and Trifunctional Inhibitors of Tumor-Associated Proteolytic Systems

2003 ◽  
Vol 384 (7) ◽  
pp. 1097-1102 ◽  
Author(s):  
J. Krol ◽  
C. Kopitz ◽  
A. Kirschenhofer ◽  
M. Schmitt ◽  
U. Magdolen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Malignant Tumors ◽  
Control Cell ◽  
Cysteine Proteases ◽  
Cysteine Protease Inhibitor ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Chicken Cystatin

AbstractSeveral proteolytic systems are involved in (anti)adhesive, migratory, and proteolytic processes, necessary for tumor progression and metastasis. We analyzed whether multifunctional inhibitors of different tumor-associated proteolytic systems reduce tumor growth and spread of human ovarian cancer cells in vivo. Bifunctional inhibitors are composed of the N-terminal domain of either the human matrix metalloproteinase inhibitors TIMP-1 or TIMP-3 and the cysteine protease inhibitor chicken cystatin (chCysWT); trifunctional inhibitors are composed of N-TIMP-1 or -3 and a chicken cystatin variant harboring the uPAR binding site of uPA, chCys-uPA19-31, which in addition to its inhibitory activity toward cysteine proteases interferes with the interaction of the serine protease uPA with its receptor. OV-MZ-6#8 cancer cells, stably transfected with plasmids expressing the multifunctional inhibitors, displayed similar proliferative and adhesive features as the vector-transfected control, but showed significant reduction in their invasive behavior in vitro. The cell lines expressing the multifunctional inhibitors were inoculated into the peritoneum of nude mice. Expression of three of the four inhibitor variants (NhTIMP-1-chCysWT, N-hTIMP-1- chCys-uPA19-31, and N-hTIMP-3-chCysWT) resulted in a significant reduction of tumor burden compared to the vector-control cell line. These compact and small inhibitors may represent promising agents for gene therapy of solid malignant tumors.

scholarly journals Inhibitory Effects of Ginsenoside Rh2on Tumor Growth in Nude Mice Bearing Human Ovarian Cancer Cells

1998 ◽  
Vol 89 (7) ◽  
pp. 733-740 ◽  
Author(s):  
Hideyuki Nakata ◽  
Yoshihiro Kikuchi ◽  
Takehiko Tode ◽  
Junko Hirata ◽  
Tsunekazu Kita ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Nude Mice ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Inhibitory Effects

A novel melittin-MhIL-2 fusion protein inhibits the growth of human ovarian cancer SKOV3 cells in vitro and in vivo tumor growth

2013 ◽  
Vol 62 (5) ◽  
pp. 889-895 ◽  
Author(s):  
Mingjun Liu ◽  
Jinbao Zong ◽  
Zimin Liu ◽  
Ling Li ◽  
Xu Zheng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Fusion Protein ◽  
Tumor Growth ◽  
Human Ovarian Cancer ◽  
Skov3 Cells
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