scholarly journals The subtelomeric region is important for chromosome recognition and pairing during meiosis

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
María del Carmen Calderón ◽  
María-Dolores Rey ◽  
Adoración Cabrera ◽  
Pilar Prieto
Keyword(s):  
Subtelomeric Region

scholarly journals Characterization of eight species of Aloe (Asphodelaceae) from the nucleolar organizing region

Rodriguésia ◽  
2018 ◽  
Vol 69 (2) ◽  
pp. 363-372
Author(s):  
Ysbelia Sánchez-G ◽  
María B. Raymúndez ◽  
José Imery ◽  
M. Cristina Acosta ◽  
Eduardo Moscone
Keyword(s):  
Subtelomeric Region ◽  
Interphase Nuclei ◽  
Nucleolar Organizing Region ◽  
Subtelomeric Regions

Abstract Nucleolar organizing region of eight species of Aloe was analyzed in somatic metaphases and interphase nuclei. All species showed a uniform 2n=14, with eight large chromosomes and six small chromosomes. Satellites were observed on the long arm of one or two pairs of large chromosomes and/or on the short arm of one of the small pairs. The silver-stained nucleolus organizing regions were located on the subtelomeric region of the long arm of one or two pairs of large chromosomes, except for Aloe dichotoma and Aloe maculata, which the AgNORs were located at a short arm of one of their small chromosomes. In most studied species, the active AgNOR number was four. However, this number changing from one to eight. For all species, the interphase number of nucleoli can be one or two, while, in Aloe excelsa, this number can be changing from one to eight. Polymorphism of active AgNORs and the number of interphase nucleoli were revealed, except for Aloe petricola, which active AgNORs were located only in the subtelomeric regions at the long arm of one of the L2 chromosomes, as well as in the L4 pair, which is agrément with the maximum number (three) of interphase nucleoli.

scholarly journals Comprehensive Analysis of Human Subtelomeres by Whole Genome Mapping

2019 ◽  
Author(s):  
Eleanor Young ◽  
Heba Z. Abid ◽  
Pui-Yan Kwok ◽  
Harold Riethman ◽  
Ming Xiao
Keyword(s):  
Long Range ◽  
Genome Mapping ◽  
Subtelomeric Region ◽  
Reference Sequence ◽  
Segmental Duplications ◽  
Structural Variations ◽  
Sequence Characterization ◽  
Current Reference ◽  
Sequencing Technologies ◽  
Chromosome Arm

AbstractDetailed comprehensive knowledge of the structures of individual long-range telomere-terminal haplotypes are needed to understand their impact on telomere function, and to delineate the population structure and evolution of subtelomere regions. However, the abundance of large evolutionarily recent segmental duplications and high levels of large structural variations have complicated both the mapping and sequence characterization of human subtelomere regions. Here, we use high throughput optical mapping of large single DNA molecules in nanochannel arrays for 154 human genomes from 26 populations to present a comprehensive look at human subtelomere structure and variation. The results catalog many novel long-range subtelomere haplotypes and determine the frequencies and contexts of specific subtelomeric duplicons on each chromosome arm, helping to clarify the currently ambiguous nature of many specific subtelomere structures as represented in the current reference sequence (HG38). The organization and content of some duplicons in subtelomeres appear to show both chromosome arm and population-specific trends. Based upon these trends we estimate a timeline for the spread of these duplication blocks.Author SummaryThe ends of human chromosomes have caps called telomeres that are essential. These telomeres are influenced by the portions of DNA next to them, a region known as the subtelomere. We need to better understand the subtelomeric region to understand how it impacts the telomeres. This subtelomeric region is not well described in the current references. This is due to large variations in this region and portions that are repeated many times, making current sequencing technologies struggle to capture these regions. Many of these variations are evolutionary recent. Here we use 154 different samples from the 26 geographic regions of the world to gain a better understanding of the variation in these regions. We found many new haplotypes and clarified the haplotypes existing in the current reference. We then examined population and chromosome specific trends.

scholarly journals A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Pascale Jolivet ◽  
Kamar Serhal ◽  
Marco Graf ◽  
Stephan Eberhard ◽  
Zhou Xu ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Replicative Senescence ◽  
Subtelomeric Region

Physical mapping of probes within 14q32, a subtelomeric region showing a high recombination frequency

Genomics ◽  
1990 ◽  
Vol 6 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Marten H. Hofker ◽  
Sarah Smith ◽  
Yusuke Nakamura ◽  
Ikuko Teshima ◽  
Ray White ◽  
...  
Keyword(s):  
Physical Mapping ◽  
Recombination Frequency ◽  
Subtelomeric Region

scholarly journals Modulation of Telomere Length Dynamics by the Subtelomeric Region of Tetrahymena Telomeres

2004 ◽  
Vol 15 (8) ◽  
pp. 3719-3728 ◽  
Author(s):  
Naduparambil K. Jacob ◽  
Angela R. Stout ◽  
Carolyn M. Price
Keyword(s):  
Telomere Length ◽  
Chromatin Structure ◽  
Gc Content ◽  
Subtelomeric Region ◽  
Base Pairs ◽  
Growth Profile ◽  
Sequence Elements ◽  
Characteristic Growth ◽  
Subtelomeric Regions ◽  
Common Sequence

Tetrahymena telomeres usually consist of ∼250 base pairs of T2G4 repeats, but they can grow to reach a new length set point of up to 900 base pairs when kept in log culture at 30°C. We have examined the growth profile of individual macronuclear telomeres and have found that the rate and extent of telomere growth are affected by the subtelomeric region. When the sequence of the rDNA subtelomeric region was altered, we observed a decrease in telomere growth regardless of whether the GC content was increased or decreased. In both cases, the ordered structure of the subtelomeric chromatin was disrupted, but the effect on the telomeric complex was relatively minor. Examination of the telomeres from non-rDNA chromosomes showed that each telomere exhibited a unique and characteristic growth profile. The subtelomeric regions from individual chromosome ends did not share common sequence elements, and they each had a different chromatin structure. Thus, telomere growth is likely to be regulated by the organization of the subtelomeric chromatin rather than by a specific DNA element. Our findings suggest that at each telomere the telomeric complex and subtelomeric chromatin cooperate to form a unique higher order chromatin structure that controls telomere length.

scholarly journals The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes.

1996 ◽  
Vol 15 (15) ◽  
pp. 4069-4077 ◽  
Author(s):  
J. P. Rubio ◽  
J. K. Thompson ◽  
A. F. Cowman
Keyword(s):  
Plasmodium Falciparum ◽  
Subtelomeric Region ◽  
Var Genes

A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax

Nature ◽  
2001 ◽  
Vol 410 (6830) ◽  
pp. 839-842 ◽  
Author(s):  
Hernando A. del Portillo ◽  
Carmen Fernandez-Becerra ◽  
Sharen Bowman ◽  
Karen Oliver ◽  
Martin Preuss ◽  
...  
Keyword(s):  
Plasmodium Vivax ◽  
Subtelomeric Region ◽  
Variant Genes
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