scholarly journals Systemic, Ocular and Genetic Risk Factors for Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Singaporeans

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chui Ming Gemmy Cheung ◽  
Augustinus Laude ◽  
Ian Yeo ◽  
Shu-Pei Tan ◽  
Qiao Fan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Genetic Risk ◽  
Polypoidal Choroidal Vasculopathy ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Choroidal Vasculopathy

Prevalence of age-related macular degeneration associated genetic risk factors and 4-year progression data in the Irish population

2018 ◽  
Vol 102 (12) ◽  
pp. 1691-1695 ◽  
Author(s):  
Emma Connolly ◽  
Maedbh Rhatigan ◽  
Aisling M O’Halloran ◽  
Katherine Alyson Muldrew ◽  
Usha Chakravarthy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Disease Progression ◽  
Genetic Risk ◽  
Risk Allele ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Complement Factor ◽  
Age Related ◽  
Soft Drusen

Background/aimsAge-related macular degeneration (AMD) is estimated to affect 196 million people >50 years old globally. Prevalence of AMD-associated genetic risk factors and rate of disease progression are unknown in Ireland.MethodsPrevalence of AMD-associated genetic risk variants, complement factor H (CFH) rs1061170, age-related maculopathy susceptibility 2 (ARMS2) rs10490924, component 3 (C3) rs2230199, complement factor B (CFB) rs641153 and superkiller viralicidic activity 2-like (SKIV2L) rs429608 and 4-year progression data in a population-representative cohort (The Irish Longitudinal study on Ageing (TILDA)) were assessed. 4473 participants ≥50 years were assessed. 4173 had no disease n=1843; 44% male and n=2330; 56% female, mean age 60±9.0, 300 had AMD n=136; 45% male and n=164; 55% female, mean age 64±9.0. A 4-year follow-up was undertaken with 66% of AMD cases attending. Progression and regression from early to late AMD were measured. Genetic association as indicators of disease and as predictors of progression were assessed by multinomial logistic regression.ResultsOlder age and the presence of CFH and ARMS2 risk alleles are two main risk factors associated with the prevalence of AMD in the TILDA cohort. 23% progressed to a higher grade of AMD. Carriers of CFH risk allele showed a strong association for disease progression. Heterozygosity for ARMS2 risk allele predicted progression to late AMD. 75% of those who progressed from early to late disease had soft drusen and hyperpigmentation at baseline.ConclusionsThe prevalence of risk-associated genes and 4-year progression rates of AMD in this Ireland cohort are comparable with other Caucasian populations. CFH Y402H is associated with disease progression, with soft drusen and hyperpigmentation as high-risk features.

Combined effects of genetic and non-genetic risk factors affect response to ranibizumab in exudative age-related macular degeneration

2014 ◽  
Vol 93 (6) ◽  
pp. e451-e457 ◽  
Author(s):  
Stefano Piermarocchi ◽  
Stefania Miotto ◽  
Davide Colavito ◽  
Alberta Leon ◽  
Tatiana Segato
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Combined Effects ◽  
Age Related

scholarly journals Genetic Risk Factors Are Not Associated with Wet Age-Related Macular Degeneration Treatment Response to Ranibizumab

2018 ◽  
Vol 239 (4) ◽  
pp. 240-240
Author(s):  
Varun Chaudhary ◽  
Michael Brent ◽  
Wai-Ching Lam ◽  
Robert Devenyi ◽  
Joshua Teichman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Treatment Response ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Age Related

P3-274: Major genetic risk factors for age-related macular degeneration are not associated with Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T602-T602
Author(s):  
M. Axel Wollmer ◽  
Aleksandra Maruszak ◽  
Magdalini Tsolaki ◽  
Elisabeth Kapaki ◽  
Dietmar R. Thal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Macular Degeneration ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0200739 ◽  
Author(s):  
Luciana M. Pujol-Lereis ◽  
Gerhard Liebisch ◽  
Tina Schick ◽  
Yuchen Lin ◽  
Felix Grassmann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Age Related Macular Degeneration ◽  
Age Related
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