scholarly journals Prevalence and Risk Factors for Nonexudative Neovascularization in Fellow Eyes of Patients With Unilateral Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy

2017 ◽  
Vol 58 (9) ◽  
pp. 3488 ◽  
Author(s):  
Yasuo Yanagi ◽  
Aditi Mohla ◽  
Won-Ki Lee ◽  
Shu Yen Lee ◽  
Ranjana Mathur ◽  
...  
Keyword(s):  
Risk Factors ◽  
Macular Degeneration ◽  
Polypoidal Choroidal Vasculopathy ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Choroidal Vasculopathy ◽  
Fellow Eyes

scholarly journals Multimodal Imaging of Unaffected Fellow Eyes in Patients with Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration

2021 ◽  
Vol 72 (2) ◽  
pp. 121-127
Author(s):  
Supalert Prakhunhungsit
Keyword(s):  
Macular Degeneration ◽  
Polypoidal Choroidal Vasculopathy ◽  
Multimodal Imaging ◽  
Fundus Autofluorescence ◽  
Case Series ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Choroidal Vasculopathy ◽  
Fellow Eyes ◽  
Sd Oct

Objective: To identify retinal abnormalities in the unaffected fellow eyes of patients with unilateral polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (n-AMD). Methods: In this cross-sectional, retrospective case series, the medical records of patients with PCV and n-AMD were reviewed and the baseline patient characteristics recorded. Abnormal findings on spectral-domain optical coherence tomography (SD-OCT) (steep/notched pigment epithelial detachment [PED], double-layer sign, hyporeflective lumen within the PED), fundus autofluorescence (FAF) (ring/patch patterns), and indocyanine green angiography (ICGA) (punctate hyperfluorescence spot [PHS]) were studied. Results: Seventy-one fellow eyes of patients with PCV and 64 fellow eyes of patients with n-AMD were included. FAF showed abnormalities in 26 (36.6%) and 33 (51.6%) fellow eyes of those with PCV and n-AMD, respectively (p=0.081). SD-OCT detected abnormalities in 25 (35.2%) and 36 (56.3%) fellow eyes of those with PCV and n-AMD, respectively (p=0.014). ICGA detected PHS in 47 (66.2%) and 34 (53.1%) fellow eyes of PCV and n-AMD, respectively (p=0.122). Conclusion: Multimodal imaging showed abnormalities in most asymptomatic fellow eyes of patients with PCV and n-AMD. Regular and long-term self-monitoring and fundus evaluation are important for these patients. The current findings support the differences in the pathogeneses of PCV and n-AMD.

scholarly journals Comparison of Choriocapillary Flow Density Between Fellow eyes of Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration

2020 ◽  
Author(s):  
Mingyue Luo ◽  
Xinyu Zhao ◽  
Nan Zhao ◽  
Mingzhen Yuan ◽  
Jingyuan Yang ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Polypoidal Choroidal Vasculopathy ◽  
Age Related Macular Degeneration ◽  
Flow Density ◽  
Fellow Eye ◽  
Age Related ◽  
And Control ◽  
Scan Pattern ◽  
Choroidal Vasculopathy ◽  
Fellow Eyes

Abstract Purpose: To compare the choriocapillary flow density (CFD) among the fellow eyes of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD) and healthy controls with spectral-domain optical coherence angiography tomography (SD-OCTA). Methods: This is a cross-sectional study, including the fellow eyes of 38 patients with unilateral PCV, 36 patients with unilateral nAMD, and 36 eyes from 36 healthy volunteers. PCV group was further classified into polypoidal CNV (P-CNV) and typical PCV (T-PCV) for subgroup analysis. Age, subfoveal choroidal thickness (SFCT), Age-Related Eye Disease Study (AREDS) classification and fellow eye diagnosis were acquired. All subjects underwent 6.0 mm scan pattern of SD-OCTA. Circles with radius of 1.00, 1.50 and 3.00 mm were manually selected in choriocapillaris (CC) slab, and CFD was calculated as the percentage of flow area to the whole selected area as CFD-1.00, 1.50, 3.00 respectively. Univariate and multivariate analysis were performed to study correlation between aforementioned factors with CFD, Results: Mean CFD-1.00, 1.50, 3.00 of nAMD group were 61.51, 63.18 and 66.20, significantly lower than PCV group (65.90, 66.89, 67.94, P<0.001 , <0.001, and 0.010, respectively) and control (66.28, 66.96, 68.42, P<0.001 , <0.001, and 0.001, respectively), while no difference were detected between PCV group and control or between PCV subtypes. AREDS classification and fellow eye diagnosis were correlated with CFD in univariate analysis, but only fellow eye diagnosis remained significantly correlated after multiple linear regression. Conclusions: CFD of nAMD fellow eyes were significantly lower than that of PCV and control eyes, while no difference was detected between PCV and control group, indicating different role of CC loss in early pathogenesis of nAMD and PCV.

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