scholarly journals TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Michiko Matsuse ◽  
Tomonori Yabuta ◽  
Vladimir Saenko ◽  
Mitsuyoshi Hirokawa ◽  
Eijun Nishihara ◽  
...  
Keyword(s):  
Prognostic Marker ◽  
Labeling Index ◽  
Papillary Thyroid ◽  
Ki 67 ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

scholarly journals Preoperative detection of the TERT promoter mutations in papillary thyroid carcinomas

2021 ◽  
Author(s):  
Tomoe Nakao ◽  
Michiko Matsuse ◽  
Vladimir Saenko ◽  
Tatiana Rogounovitch ◽  
Aya Tanaka ◽  
...  
Keyword(s):  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

scholarly journals Preoperative Detection of the TERT Promoter Mutations in Papillary Thyroid Carcinomas

2021 ◽  
Author(s):  
Tomoe Nakao ◽  
Michiko Matsuse ◽  
Vladimir Saenko ◽  
Tatiana Rogounovitch ◽  
Aya Tanaka ◽  
...  
Keyword(s):  
Needle Aspiration ◽  
Papillary Thyroid ◽  
Ki 67 ◽  
Thyroid Carcinomas ◽  
Good Ability ◽  
Mutational Status ◽  
Tert Promoter Mutations ◽  
Ffpe Samples ◽  
Promoter Mutations

Abstract Telomerase reverse transcriptase promoter (TERT-p) mutations are strongly associated with tumor aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). Since the TERT-p promoter mutations have been reported to be subclonal, it is unclear how accurately they can be detected by preoperative fine needle aspiration (FNA). The objective of this study was to analyze the concordance rate of the TERT-p mutations between preoperative FNA and corresponding postoperative surgical specimens. The mutational status of the TERT-p in FNA samples detected by our ddPCR assay was highly concordant with that in postoperative FFPE specimens. The TERT-p mutation was significantly associated with age, tumor size, extrathyroidal extension, and the Ki-67 labeling index in multivariate analysis in both FNA and FFPE samples. The detection of the TERT-p mutations using FNA samples has a good ability to predict disease aggressiveness and, therefore, could be clinically useful in the determination of PTC management.

Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population

Thyroid ◽  
2016 ◽  
Vol 26 (7) ◽  
pp. 901-910 ◽  
Author(s):  
Seung Eun Lee ◽  
Tae Sook Hwang ◽  
Yoon-La Choi ◽  
Hye Seung Han ◽  
Wan Seop Kim ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

Frequent BRAF V600E and Absence of TERT Promoter Mutations Characterize Sporadic Pediatric Papillary Thyroid Carcinomas in Japan

2017 ◽  
Vol 28 (2) ◽  
pp. 103-111 ◽  
Author(s):  
Naoki Oishi ◽  
Tetsuo Kondo ◽  
Tadao Nakazawa ◽  
Kunio Mochizuki ◽  
Tomohiro Inoue ◽  
...  
Keyword(s):  
Braf V600e ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

scholarly journals Ultrasound and clinicopathological features of papillary thyroid carcinomas with BRAF and TERT promoter mutations

Oncotarget ◽  
2017 ◽  
Vol 8 (65) ◽  
pp. 108946-108957 ◽  
Author(s):  
Soo Yeon Hahn ◽  
Tae Hyuk Kim ◽  
Chang Seok Ki ◽  
Sun Wook Kim ◽  
Soohyun Ahn ◽  
...  
Keyword(s):  
Clinicopathological Features ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

Classic Architecture with Multicentricity and Local Recurrence, and Absence of TERT Promoter Mutations are Correlates of BRAF V600E Harboring Pediatric Papillary Thyroid Carcinomas

2016 ◽  
Vol 27 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Semen Onder ◽  
Sule Ozturk Sari ◽  
Gulcin Yegen ◽  
Ismail Cem Sormaz ◽  
Ismail Yilmaz ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

scholarly journals TERT promoter mutations are a major indicator of recurrence and death due to papillary thyroid carcinomas

2016 ◽  
Vol 85 (2) ◽  
pp. 283-290 ◽  
Author(s):  
Martyn Bullock ◽  
Yan Ren ◽  
Christine O'Neill ◽  
Anthony Gill ◽  
Adam Aniss ◽  
...  
Keyword(s):  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

Prognostic significance of TERT promoter mutations in follicular cell-derived thyroid carcinomas

2014 ◽  
Author(s):  
Miguel Melo ◽  
Rocha Adriana Gaspar da ◽  
Joao Vinagre ◽  
Rui Batista ◽  
Joana Peixoto ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Follicular Cell ◽  
Thyroid Carcinomas ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

In papillary thyroid cancer TERT promoter mutations have a worst impact on outcome than BRAF mutations

2015 ◽  
Author(s):  
Marina Muzza ◽  
Carla Colombo ◽  
Maria Carla Proverbio ◽  
Stefania Rossi ◽  
Delfina Tosi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Braf Mutations ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations

scholarly journals TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

2014 ◽  
Vol 99 (5) ◽  
pp. E754-E765 ◽  
Author(s):  
Miguel Melo ◽  
Adriana Gaspar da Rocha ◽  
João Vinagre ◽  
Rui Batista ◽  
Joana Peixoto ◽  
...  
Keyword(s):  
Thyroid Carcinomas ◽  
Poor Outcome ◽  
Tert Promoter ◽  
Tert Promoter Mutations ◽  
Promoter Mutations
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