scholarly journals Genome-wide random regression analysis for parent-of-origin effects of body composition allometries in mouse

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jingli Zhao ◽  
Shuling Li ◽  
Lijuan Wang ◽  
Li Jiang ◽  
Runqing Yang ◽  
...  
Keyword(s):  
Body Composition ◽  
Regression Analysis ◽  
Random Regression ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Parent-of-origin effects on voluntary exercise levels and body composition in mice

2010 ◽  
Vol 40 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Scott A. Kelly ◽  
Derrick L. Nehrenberg ◽  
Kunjie Hua ◽  
Ryan R. Gordon ◽  
Theodore Garland ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Wheel Running ◽  
Voluntary Exercise ◽  
Phenotypic Variance ◽  
In Utero Environment ◽  
Dependent Activity ◽  
Health Related ◽  
Parent Of Origin ◽  
Origin Effects

Despite the health-related benefits of exercise, many people do not engage in enough activity to realize the rewards, and little is known regarding the genetic or environmental components that account for this individual variation. We created and phenotyped a large G4 advanced intercross line originating from reciprocal crosses between mice with genetic propensity for increased voluntary exercise (HR line) and the inbred strain C57BL/6J. G4 females (compared to males) ran significantly more when provided access to a running wheel and were smaller with a greater percentage of body fat pre- and postwheel access. Change in body composition resulting from a 6-day exposure to wheels varied between the sexes with females generally regulating energy balance more precisely in the presence of exercise. We observed parent-of-origin effects on most voluntary wheel running and body composition traits, which accounted for 3–13% of the total phenotypic variance pooled across sexes. G4 individuals descended from progenitor (F0) crosses of HR♀ and C57BL/6J♂ ran greater distances, spent more time running, ran at higher maximum speeds/day, and had lower percent body fat and higher percent lean mass than mice descended from reciprocal progenitor crosses (C57BL/6J♀ × HR♂). For some traits, significant interactions between parent of origin and sex were observed. We discuss these results in the context of sex dependent activity and weight loss patterns, the contribution of parent-of-origin effects to predisposition for voluntary exercise, and the genetic (i.e., X-linked or mtDNA variations), epigenetic (i.e., genomic imprinting), and environmental (i.e., in utero environment or maternal care) phenomena potentially modulating these effects.

scholarly journals Genome-Wide Linkage Analysis Assessing Parent-of-Origin Effects in the Inheritance of Type 2 Diabetes and BMI in Pima Indians

Diabetes ◽  
2001 ◽  
Vol 50 (12) ◽  
pp. 2850-2857 ◽  
Author(s):  
R. S. Lindsay ◽  
S. Kobes ◽  
W. C. Knowler ◽  
P. H. Bennett ◽  
R. L. Hanson
Keyword(s):  
Type 2 Diabetes ◽  
Linkage Analysis ◽  
Pima Indians ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12513 ◽  
Author(s):  
Delphine Fradin ◽  
Keely Cheslack-Postava ◽  
Christine Ladd-Acosta ◽  
Craig Newschaffer ◽  
Aravinda Chakravarti ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts

2012 ◽  
Vol 158A (4) ◽  
pp. 784-794 ◽  
Author(s):  
Min Shi ◽  
Jeffrey C. Murray ◽  
Mary L. Marazita ◽  
Ronald G. Munger ◽  
Ingo Ruczinski ◽  
...  
Keyword(s):  
Orofacial Clefts ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Genome Wide Study

scholarly journals Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

2018 ◽  
Vol 27 (16) ◽  
pp. 2927-2939 ◽  
Author(s):  
Gabriel Cuellar Partida ◽  
Charles Laurin ◽  
Susan M Ring ◽  
Tom R Gaunt ◽  
Allan F McRae ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects ◽  
Genome Wide Survey

scholarly journals CmCGG Methylation-Independent Parent-of-Origin Effects on Genome-Wide Transcript Levels in Isogenic Reciprocal F1 Triploid Plants

DNA Research ◽  
2013 ◽  
Vol 21 (2) ◽  
pp. 141-151 ◽  
Author(s):  
M. T. A. Donoghue ◽  
A. Fort ◽  
R. Clifton ◽  
X. Zhang ◽  
P. C. McKeown ◽  
...  
Keyword(s):  
Transcript Levels ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals A statistical test for detecting parent-of-origin effects when parental information is missing

2017 ◽  
Vol 16 (4) ◽  
Author(s):  
Chiara Sacco ◽  
Cinzia Viroli ◽  
Mario Falchi
Keyword(s):  
Study Data ◽  
Epigenetic Mechanism ◽  
Parental Origin ◽  
Reference Allele ◽  
Parental Effect ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Related Individuals ◽  
Origin Effects ◽  
Parental Information

AbstractGenomic imprinting is an epigenetic mechanism that leads to differential contributions of maternal and paternal alleles to offspring gene expression in a parent-of-origin manner. We propose a novel test for detecting the parent-of-origin effects (POEs) in genome wide genotype data from related individuals (twins) when the parental origin cannot be inferred. The proposed method exploits a finite mixture of linear mixed models: the key idea is that in the case of POEs the population can be clustered in two different groups in which the reference allele is inherited by a different parent. A further advantage of this approach is the possibility to obtain an estimation of parental effect when the parental information is missing. We will also show that the approach is flexible enough to be applicable to the general scenario of independent data. The performance of the proposed test is evaluated through a wide simulation study. The method is finally applied to known imprinted genes of the MuTHER twin study data.

scholarly journals A powerful genome-wide feasible approach to detect parent-of-origin effects in studies of quantitative traits

2009 ◽  
Vol 18 (3) ◽  
pp. 379-384 ◽  
Author(s):  
Nadezhda M Belonogova ◽  
Tatiana I Axenovich ◽  
Yurii S Aulchenko
Keyword(s):  
Quantitative Traits ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects

scholarly journals Genome-wide analysis of parent-of-origin effects in non-syndromic orofacial clefts

2013 ◽  
Vol 22 (6) ◽  
pp. 822-830 ◽  
Author(s):  
Paras Garg ◽  
Kerstin U Ludwig ◽  
Anne C Böhmer ◽  
Michele Rubini ◽  
Regine Steegers-Theunissen ◽  
...  
Keyword(s):  
Orofacial Clefts ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Parent Of Origin ◽  
Origin Effects
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