scholarly journals Impact of molecular subtypes on metastatic breast cancer patients: a SEER population-based study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yue Gong ◽  
Yi-Rong Liu ◽  
Peng Ji ◽  
Xin Hu ◽  
Zhi-Ming Shao
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Molecular Subtypes ◽  
Metastatic Breast ◽  
Population Based ◽  
Breast Cancer Patients ◽  
Population Based Study

Abstract P2-08-03: Machine learning to identify and characterize metastatic breast cancer patients in Sweden: A population-based study. CLEE011ASE01

2020 ◽  
Author(s):  
Henrik Lindman ◽  
Mate Szilcz ◽  
Jonatan Freilich ◽  
Peter Carlqvist ◽  
Simona Vertuani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Population Based ◽  
Breast Cancer Patients ◽  
Population Based Study

Comparison of outcomes in a population-based cohort of metastatic breast cancer patients receiving anti-HER2 therapy with clinical trial outcomes

2020 ◽  
Vol 181 (1) ◽  
pp. 155-165 ◽  
Author(s):  
Inna Y. Gong ◽  
Andrew T. Yan ◽  
Craig C. Earle ◽  
Maureen E. Trudeau ◽  
Andrea Eisen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trial ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Population Based ◽  
Breast Cancer Patients ◽  
Trial Outcomes

scholarly journals Breast Subtypes and Prognosis of Breast Cancer Patients With Initial Bone Metastasis: A Population-Based Study

2020 ◽  
Vol 10 ◽  
Author(s):  
Deyue Liu ◽  
Jiayi Wu ◽  
Caijin Lin ◽  
Lisa Andriani ◽  
Shuning Ding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Metastatic Breast Cancer ◽  
Bone Metastasis ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Risk Groups ◽  
Population Based ◽  
Breast Cancer Patients

BackgroundMetastatic breast cancer (MBC) is a highly heterogeneous disease and bone is one of the most common metastatic sites. This retrospective study was conducted to investigate the clinical features, prognostic factors and benefits of surgery of breast cancer patients with initial bone metastases.MethodsFrom 2010 to 2015, 6,860 breast cancer patients diagnosed with initial bone metastasis were analyzed from Surveillance, Epidemiology, and End Results (SEER) database. Univariate and Multivariable analysis were used to identify prognostic factors. A nomogram was performed based on the factors selected from cox regression result. Survival curves were plotted according to different subtypes, metastatic burdens and risk groups differentiated by nomogram.ResultsHormone receptor (HR) positive/human epidermal growth factor receptor 2 (HER2) positive patients showed the best outcome compared to other subtypes. Patients of younger age (<60 years old), white race, lower grade, lower T stage (<=T2), not combining visceral metastasis tended to have better outcome. About 37% (2,249) patients received surgery of primary tumor. Patients of all subtypes could benefit from surgery. Patients of bone-only metastases (BOM), bone and liver metastases, bone and lung metastases also showed superior survival time if surgery was performed. However, patients of bone and brain metastasis could not benefit from surgery (p = 0.05). The C-index of nomogram was 0.66. Cutoff values of nomogram point were identified as 87 and 157 points, which divided all patients into low-, intermediate- and high-risk groups. Patients of all groups showed better overall survival when receiving surgery.ConclusionOur study has provided population-based prognostic analysis in patients with initial bone metastatic breast cancer and constructed a predicting nomogram with good accuracy. The finding of potential benefit of surgery to overall survival will cast some lights on the treatment tactics of this group of patients.

Prognosis of breast cancer patients with initial bone metastasis: A population-based study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13081-e13081
Author(s):  
Deyue LIU ◽  
Jiayi Wu ◽  
Li Zhu
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Metastatic Breast Cancer ◽  
Bone Metastasis ◽  
Cancer Patients ◽  
Risk Group ◽  
Metastatic Breast ◽  
Population Based ◽  
Breast Cancer Patients

e13081 Background: Metastatic breast cancer (MBC) is a highly heterogeneous disease and bone is one of the most common metastatic sites. This retrospective study was conducted to investigate the clinical features, prognostic factors and benefits of surgery of breast cancer patients with initial bone metastases. Methods: From 2010 to 2015, 6860 breast cancer patients diagnosed with initial bone metastasis were analysed from Surveillance, Epidemiology, and End Results (SEER) database. Univariate and Multivariable analysis were used to identify prognostic factors. A nomogram was performed based on the factors selected from cox regression result. Survival curves were plotted according to different subtypes, metastatic burdens and risk group differentiated by nomogram. Results: Hormone receptor (HR) positive/human epidermal growth factor receptor 2 (HER2) positive patients showed the best outcome compared to other subtypes. Patients of younger age ( < 60 years old), white race, lower grade, lower T stage ( < = T2), not combining organ metastasistend to have better outcome. About 37% (2249) patients received surgery of primary tumor. Patients of all subtypes can benefit from surgery. Patients of bone-only metastases (BOM), bone and liver metastases, bone and lung metastases also showed superior survival time if surgery is performed. While patients of bone and brain patients cannot benefit from surgery (p = 0.05). The C-index of nomogram is 0.68. A cutoff value of nomogram point was identified by ROC curve as 93 points, which divided all patients into low-risk group and high-risk group. Patients of both groups showed better overall survival when receiving surgery. Conclusions: Our study has provided population-based nomogram in patients with initial bone metastatic breast cancer. The finding of potential benefit of surgery to overall survival will cast some light on the treatment tactics of this group of patients.

scholarly journals Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Meng-Ting Chen ◽  
He-Fen Sun ◽  
Yang Zhao ◽  
Wen-Yan Fu ◽  
Li-Peng Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Age Groups ◽  
Metastatic Breast ◽  
Population Based ◽  
Breast Cancer Patients

scholarly journals Local Surgery Improves Survival in Patients with Primary Metastatic Breast Cancer: A Population-Based Study

Breast Care ◽  
2019 ◽  
Vol 15 (4) ◽  
pp. 392-399
Author(s):  
Yuan-Yuan Zhao ◽  
He-Fen Sun ◽  
Xue-Li Yang ◽  
Yang Zhao ◽  
Meng-Ting Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Population Based ◽  
Primary Breast Tumor ◽  
Breast Cancer Patients ◽  
Clinical Value ◽  
Cancer Specific Survival ◽  
Local Surgery

The clinical value of local surgery in the breast cancer patients with distant metastasis is still unclear. A total of 8,922 primary metastatic breast cancer patients from the Surveillance, Epidemiology, and End Results (SEER) database were analyzed in the current study. Primary outcome variables included breast cancer-specific survival (BCSS) and overall survival (OS). Among the patients, 1,724 (19.3%) who underwent surgical treatment (ST) of primary breast tumor had increased OS (p < 0.001) and BCSS (p < 0.001) compared with those in the nonsurgical treatment (NST) group. Multivariate analysis revealed that surgery improved survival and was an independent prognostic factor for OS (hazard ratio [HR] = 0.617; 95% confidence interval [CI], 0.562–0.676, p < 0.001) and BCSS (HR = 0.623; 95% CI, 0.565–0.686, p < 0.001). Further result showed that ST tended to prolong the survival of patients with 1 or 2 distant metastatic sites (p < 0.05 for OS, p < 0.05 for BCSS). However, no differences were found in prognostic outcomes between different surgical procedure groups (p = 0.886 for OS, p = 0.943 for BCSS). In conclusion,our study suggested that local surgery appeared to confer a survival benefit, which may provide new understanding of treatment for these patients.

Metastatic Breast Cancer Patients Rarely in Trials

2010 ◽  
Vol 40 (2) ◽  
pp. 46
Author(s):  
BRUCE JANCIN
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Patients ◽  
Metastatic Breast ◽  
Breast Cancer Patients
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