scholarly journals PCLO rs2522833-mediated gray matter volume reduction in patients with drug-naive, first-episode major depressive disorder

2017 ◽  
Vol 7 (5) ◽  
pp. e1140-e1140 ◽  
Author(s):  
R Igata ◽  
A Katsuki ◽  
S Kakeda ◽  
K Watanabe ◽  
N Igata ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Reduction ◽  
First Episode ◽  
Major Depressive ◽  
Matter Volume ◽  
Drug Naïve

scholarly journals Association between cytomegalovirus infection, reduced gray matter volume, and resting-state functional hypoconnectivity in major depressive disorder: a replication and extension

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haixia Zheng ◽  
Bart N. Ford ◽  
Rayus Kuplicki ◽  
Kaiping Burrows ◽  
Peter W. Hunt ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gray Matter ◽  
Resting State ◽  
Gray Matter Volume ◽  
Brain Regions ◽  
Affective Processing ◽  
Resting State Functional Connectivity ◽  
Major Depressive ◽  
Matter Volume

AbstractHuman cytomegalovirus (HCMV) is a neurotropic herpes virus known to cause neuropathology in patients with impaired immunity. Previously, we reported a reduction in the gray matter volume (GMV) of several brain regions in two independent samples of participants who were seropositive for HCMV (HCMV+) compared to matched participants who were seronegative for HCMV (HCMV−). In addition to an independent replication of the GMV findings, this study aimed to examine whether HCMV+ was associated with differences in resting-state functional connectivity (rsfMRI-FC). After balancing on 11 clinical/demographic variables using inverse probability of treatment weighting (IPTW), GMV and rsfMRI-FC were obtained from 99 participants with major depressive disorder (MDD) who were classified into 42 HCMV+ and 57 HCMV− individuals. Relative to the HCMV− group, the HCMV+ group showed a significant reduction of GMV in nine cortical regions. Volume reduction in the right lateral orbitofrontal cortex (standardized beta coefficient (SBC) = −0.32, [95%CI, −0.62 to −0.02]) and the left pars orbitalis (SBC = −0.34, [95%CI, −0.63 to −0.05]) in the HCMV+ group was also observed in the previous study. Regardless of the parcellation method or analytical approach, relative to the HCMV− group, the HCMV+ group showed hypoconnectivity between the hubs of the sensorimotor network (bilateral postcentral gyrus) and the hubs of the salience network (bilateral insula) with effect sizes ranging from SBC = −0.57 to −0.99. These findings support the hypothesis that a positive HCMV serostatus is associated with altered connectivity of regions that are important for stress and affective processing and further supports a possible etiological role of HCMV in depression.

Effect of electroconvulsive therapy on gray matter volume in major depressive disorder

2015 ◽  
Vol 186 ◽  
pp. 186-191 ◽  
Author(s):  
Miho Ota ◽  
Takamasa Noda ◽  
Noriko Sato ◽  
Mitsutoshi Okazaki ◽  
Masatoshi Ishikawa ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Electroconvulsive Therapy ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Major Depressive ◽  
Matter Volume

Gray matter volume and rapid decision-making in major depressive disorder

2014 ◽  
Vol 48 ◽  
pp. 51-56 ◽  
Author(s):  
Masayuki Nakano ◽  
Koji Matsuo ◽  
Mami Nakashima ◽  
Toshio Matsubara ◽  
Kenichiro Harada ◽  
...  
Keyword(s):  
Decision Making ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Major Depressive ◽  
Matter Volume

scholarly journals Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

2016 ◽  
Vol 12 ◽  
pp. 492-498 ◽  
Author(s):  
Zonglin Shen ◽  
Yuqi Cheng ◽  
Shuran Yang ◽  
Nan Dai ◽  
Jing Ye ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Grey Matter ◽  
First Episode ◽  
Grey Matter Volume ◽  
Major Depressive ◽  
Matter Volume ◽  
Drug Naïve

scholarly journals Insular and Hippocampal Gray Matter Volume Reductions in Patients with Major Depressive Disorder

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102692 ◽  
Author(s):  
Mirjam Stratmann ◽  
Carsten Konrad ◽  
Harald Kugel ◽  
Axel Krug ◽  
Sonja Schöning ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Major Depressive ◽  
Matter Volume
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