scholarly journals ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease

2011 ◽  
Vol 13 (1) ◽  
pp. 52-59 ◽  
Author(s):  
Y Onouchi ◽  
Y Suzuki ◽  
H Suzuki ◽  
M Terai ◽  
K Yasukawa ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Lesion ◽  
Lesion Formation

scholarly journals IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e105195 ◽  
Author(s):  
Wan-Ning Tseng ◽  
Mao-Hung Lo ◽  
Mindy Ming-Huey Guo ◽  
Kai-Sheng Hsieh ◽  
Wei-Chiao Chang ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Lesion ◽  
Lesion Formation

scholarly journals Decreased DNA methyltransferases expression is associated with coronary artery lesion formation in Kawasaki disease

2019 ◽  
Vol 16 (4) ◽  
pp. 576-582 ◽  
Author(s):  
Ying-Hsien Huang ◽  
Kuang-Den Chen ◽  
Mao-Hung Lo ◽  
Xin-Yuan Cai ◽  
Ling-Sai Chang ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Dna Methyltransferases ◽  
Coronary Artery Lesion ◽  
Lesion Formation

scholarly journals Lack of Association betweenCLEC5AGene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ya-Ling Yang ◽  
Wei-Pin Chang ◽  
Yu-Wen Hsu ◽  
Wei-Chiao Chen ◽  
Hong-Ren Yu ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Single Nucleotide Polymorphisms ◽  
Treatment Response ◽  
Intravenous Immunoglobulin ◽  
Coronary Artery Lesion ◽  
Nucleotide Polymorphisms ◽  
Lesion Formation ◽  
Single Nucleotide ◽  
Immunoglobulin Treatment

Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD.Methods. A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) ofCLEC5A(rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test.Results. No significant associations were noted between the genotypes and allele frequency of the 4CLEC5AtSNPs between controls and patients. In the patients, polymorphisms ofCLEC5Ashowed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response.Conclusions. This study showed for the first time that polymorphisms ofCLEC5Aare not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.

scholarly journals Z-score is a possible predictor of the risk of coronary artery lesion development in patients with Kawasaki disease in Japan

2021 ◽  
Author(s):  
Takayuki Suzuki ◽  
Nobuyuki Kakimoto ◽  
Tomoya Tsuchihashi ◽  
Tomohiro Suenaga ◽  
Takashi Takeuchi ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Lesion ◽  
Z Score ◽  
Lesion Development

Clinical significance of serum soluble TNF receptor II level and soluble TNF receptor II/I ratio as indicators of coronary artery lesion development in Kawasaki disease

Cytokine ◽  
2018 ◽  
Vol 108 ◽  
pp. 168-172 ◽  
Author(s):  
Masaki Shimizu ◽  
Mao Mizuta ◽  
Masaaki Usami ◽  
Natsumi Inoue ◽  
Yasuhisa Sakakibara ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Clinical Significance ◽  
Coronary Artery Lesion ◽  
Tnf Receptor ◽  
Lesion Development ◽  
Soluble Tnf Receptor

Association of MnSOD gene polymorphism with susceptibility to Kawasaki disease in Chinese children

2020 ◽  
pp. 1-7
Author(s):  
Jiping Wu ◽  
Meng Yu ◽  
Lihua Huang ◽  
Yujie Qian ◽  
Min Kong ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Human Body ◽  
Gene Polymorphisms ◽  
Coronary Artery Lesion ◽  
Nucleotide Polymorphisms ◽  
Coronary Artery Lesions ◽  
Single Nucleotide ◽  
Significant Difference ◽  
Mnsod Gene

Abstract Background: Kawasaki disease is a type of acute febrile rash disease that is common in children and is characterised by primary lesions of systemic middle and small vasculitis, which can lead to coronary artery lesions. Manganese superoxide dismutase (MnSOD), one of the most important antioxidases in the human body, plays a key role in maintaining the balance of free radicals in the human body. Two single-nucleotide polymorphisms (SNPS) (rs4880 and rs5746136) in the MnSOD gene were related to oxidative stress disease. The purpose of this study is to explore the possible relationship between MnSOD gene polymorphisms and Kawasaki disease susceptibility. Methods: This study included 100 Kawasaki disease children and 102 healthy children. Two single-nucleotide polymorphisms (rs4880 and rs5746136) were detected by polymerase chain reaction sequence-based typing. Results: There was a significant difference in both the genotype frequency (χ2 = 10.805, p = 0.005) and the allele frequency (χ2 = 7.948, p = 0.005) of rs5746136 between the Kawasaki disease group and the control group. Children with the A allele had a 0.558 times lower risk of Kawasaki disease than those without the A allele (χ2 = 7.948, p = 0.005, odds ratio = 0.558, 95% confidence interval = 0.371–0.838). There was no significant difference in the genotype and gene frequencies of rs5746136 between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesion groups (p > 0.05), and there was no significant difference in the rs4880 genotype and allele frequencies between the Kawasaki disease and healthy control groups or between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesions groups (p > 0.05). Conclusion: This study provides evidence supporting an association between MnSOD gene polymorphisms and susceptibility to Kawasaki disease. The genotype AA and the allele A of the MnSOD gene locus rs5746136 were risk factors for Kawasaki disease.

scholarly journals Serum Tenascin-C as a Novel Predictor for Risk of Coronary Artery Lesion and Resistance to Intravenous Immunoglobulin in Kawasaki Disease　– A Multicenter Retrospective Study –

2016 ◽  
Vol 80 (11) ◽  
pp. 2376-2381 ◽  
Author(s):  
Yoshiaki Okuma ◽  
Kenji Suda ◽  
Hideyuki Nakaoka ◽  
Yasuhiro Katsube ◽  
Yoshihide Mitani ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Coronary Artery ◽  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Coronary Artery Lesion ◽  
Tenascin C

Guidelines for catheter intervention in coronary artery lesion in Kawasaki disease

2001 ◽  
Vol 43 (5) ◽  
pp. 558-562 ◽  
Author(s):  
Masahiro Ishii ◽  
Takafumi Ueno ◽  
Teiji Akagi ◽  
Kiyoshi Baba ◽  
Kensuke Harada ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Coronary Artery Lesion ◽  
Catheter Intervention
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