Simple method to assess the maximum bio-accessibility of elements from food using flow injection and inductively coupled plasma mass spectrometry

2004 ◽  
Vol 19 (9) ◽  
pp. 1213-1216 ◽  
Author(s):  
Mingyan Chu ◽  
Diane Beauchemin
Keyword(s):  
Mass Spectrometry ◽  
Flow Injection ◽  
Inductively Coupled Plasma ◽  
Simple Method ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry

A simple equation to correct for gadolinium interference on plasma selenium measurement using inductively coupled plasma mass spectrometry

2020 ◽  
Vol 57 (3) ◽  
pp. 234-241
Author(s):  
Scott Wilschefski ◽  
Matthew Baxter ◽  
Gertruida Pool
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Clinical Samples ◽  
Resonance Imaging ◽  
Simple Method ◽  
Plasma Selenium ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Delays In Diagnosis

Background The measurement of selenium in human plasma is useful to assess deficiency or toxicity. The presence of gadolinium in clinical samples following administration of certain contrast agents used for magnetic resonance imaging can cause a significant positive bias in selenium results when measured using quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS). Methods A mathematical equation to correct for gadolinium interference was assessed using both patient samples and commercial quality control/external quality assurance (QC/EQA) materials spiked with gadolinium. Samples were analysed using an Agilent 7900 ICP-MS operated in ‘narrow peak’ (half-mass) mode. Accuracy was evaluated by comparing corrected selenium results with target concentrations. Results Corrected results were found to be accurate at all gadolinium concentrations tested (2, 4, 10 and 20 mg/L). Average recoveries ranged from 97.4 to 106.5%. Results for QC/EQA materials were within specified target ranges. Within-run imprecision was <3%, and between-run imprecision was <4.3%, demonstrating robustness. Conclusions The correction equation described here is a simple method to correct for gadolinium interference on plasma selenium measurement using ICP-MS. This approach eliminates the need for specimen recollections, and improves patient care by reducing laboratory turnaround times and preventing delays in diagnosis/treatment.

On-Line Trace Enrichment and Determination of Uranium in Waters by Flow Injection Inductively Coupled Plasma Mass Spectrometry

1994 ◽  
Vol 48 (11) ◽  
pp. 1331-1336 ◽  
Author(s):  
Shayessteh Dadfarnia ◽  
Cameron W. McLeod
Keyword(s):  
Mass Spectrometry ◽  
Flow Injection ◽  
Inductively Coupled Plasma ◽  
Sea Water ◽  
Trace Enrichment ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
On Line ◽  
Line Trace

A flow injection system incorporating a microcolumn of activated alumina was combined with inductively coupled plasma mass spectrometry for on-line trace enrichment and determination of uranium in surface waters and sea water. Deposition of uranium was effected with the use of a basic alumina microcolumn, and injection of nitric acid (250 μL, 2M) served to elute retained species to the ICP. A sample volume of 14 mL resulted in a preconcentration factor of 40, and precision at the 50-ng 1−1 level was 4.5% (RSD). The procedure was applied to mineral waters, river water, and sea water, and accuracy was assessed through either analysis of certified reference waters or recovery experiments.

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