scholarly journals Single-molecule sequence detection via microfluidic planar extensional flow at a stagnation point

Lab on a Chip ◽  
2010 ◽  
Vol 10 (12) ◽  
pp. 1543 ◽  
Author(s):  
Rebecca Dylla-Spears ◽  
Jacqueline E. Townsend ◽  
Linda Jen-Jacobson ◽  
Lydia L. Sohn ◽  
Susan J. Muller
Keyword(s):  
Stagnation Point ◽  
Single Molecule ◽  
Extensional Flow ◽  
Sequence Detection ◽  
Planar Extensional Flow

scholarly journals Nanopore Technology for the Application of Protein Detection

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1942
Author(s):  
Xiaoqing Zeng ◽  
Yang Xiang ◽  
Qianshan Liu ◽  
Liang Wang ◽  
Qianyun Ma ◽  
...  
Keyword(s):  
Single Molecule ◽  
Protein Detection ◽  
High Sensitivity ◽  
Single Molecule Detection ◽  
Sequence Detection ◽  
Fast Detection ◽  
Material Basis ◽  
Sensing Technology ◽  
Detection Technology ◽  
Structure Recognition

Protein is an important component of all the cells and tissues of the human body and is the material basis of life. Its content, sequence, and spatial structure have a great impact on proteomics and human biology. It can reflect the important information of normal or pathophysiological processes and promote the development of new diagnoses and treatment methods. However, the current techniques of proteomics for protein analysis are limited by chemical modifications, large sample sizes, or cumbersome operations. Solving this problem requires overcoming huge challenges. Nanopore single molecule detection technology overcomes this shortcoming. As a new sensing technology, it has the advantages of no labeling, high sensitivity, fast detection speed, real-time monitoring, and simple operation. It is widely used in gene sequencing, detection of peptides and proteins, markers and microorganisms, and other biomolecules and metal ions. Therefore, based on the advantages of novel nanopore single-molecule detection technology, its application to protein sequence detection and structure recognition has also been proposed and developed. In this paper, the application of nanopore single-molecule detection technology in protein detection in recent years is reviewed, and its development prospect is investigated.

Experimental trajectories of two drops in planar extensional flow

1999 ◽  
Vol 11 (5) ◽  
pp. 971-981 ◽  
Author(s):  
Derek C. Tretheway ◽  
Masahiro Muraoka ◽  
L. Gary Leal
Keyword(s):  
Extensional Flow ◽  
Planar Extensional Flow

Stagnation-point extensional flow behaviour of M1

1990 ◽  
Vol 35 (2-3) ◽  
pp. 231-250 ◽  
Author(s):  
A.J. Müller ◽  
J.A. Odell ◽  
J.P. Tatham
Keyword(s):  
Stagnation Point ◽  
Extensional Flow ◽  
Flow Behaviour

Numerical Simulation of Orientation Distribution on Fibers Suspensions in Planar Extensional Field

2013 ◽  
Vol 395-396 ◽  
pp. 1174-1178
Author(s):  
Pei Fang Luo ◽  
Zan Huang
Keyword(s):  
Differential Equation ◽  
Numerical Simulation ◽  
Mathematical Model ◽  
Partial Differential Equation ◽  
Fiber Orientation ◽  
Extensional Flow ◽  
Orientation Distribution ◽  
Specific Form ◽  
Fiber Orientation Distribution ◽  
Planar Extensional Flow

A mathematical model of evolution process is adopted to simulate orientation distribution of fibers suspensions in planar extensional flow, i.e., specific form of Fokker-Plank partial differential equation and Jeffery equation. The analytical solution of differential equation on forecast fiber orientation distribution is deduced.

Effect of Hydrodynamic Interactions on DNA Dynamics in Extensional Flow:  Simulation and Single Molecule Experiment

2004 ◽  
Vol 37 (24) ◽  
pp. 9242-9256 ◽  
Author(s):  
Charles M. Schroeder ◽  
Eric S. G. Shaqfeh ◽  
Steven Chu
Keyword(s):  
Single Molecule ◽  
Extensional Flow ◽  
Flow Simulation ◽  
Hydrodynamic Interactions ◽  
Dna Dynamics

Use of Stagnation Point Flows for DNA Trapping, Manipulation, and Target Sequence Detection

2008 ◽  
Author(s):  
Rebecca Dylla-Spears ◽  
Lydia L. Sohn ◽  
Susan J. Muller ◽  
Albert Co ◽  
Gary L. Leal ◽  
...  
Keyword(s):  
Stagnation Point ◽  
Target Sequence ◽  
Sequence Detection ◽  
Dna Trapping

Numerical Simulation of Dynamics on Plant Fibers Suspension in Shear-Planar Extensional Flow

2014 ◽  
Vol 1056 ◽  
pp. 66-69 ◽  
Author(s):  
Zan Huang
Keyword(s):  
Differential Equation ◽  
Numerical Simulation ◽  
Flow Field ◽  
Mathematical Simulation ◽  
Extensional Flow ◽  
Simulation Method ◽  
Complex Flow ◽  
Plant Fibers ◽  
Fibers Orientation ◽  
Planar Extensional Flow

A mathematical simulation method is applied to simulate dynamics on plant fibers suspensions in shear-planar extensional flow. Furthermore, the result of differential equation on plant fibers orientation can be obtained in complex flow field.

scholarly journals Dynamics and rheology of ring-linear blend semidilute solutions in extensional flow: Single molecule experiments

2021 ◽  
Vol 65 (4) ◽  
pp. 729-744
Author(s):  
Yuecheng Zhou ◽  
Charles D. Young ◽  
Megan Lee ◽  
Sourya Banik ◽  
Dejie Kong ◽  
...  
Keyword(s):  
Single Molecule ◽  
Extensional Flow ◽  
Semidilute Solutions

Agglomerate Breakup of Destabilized Polystyrene Particles under a Cross-Channel Planar Extensional Flow

Langmuir ◽  
2018 ◽  
Vol 34 (38) ◽  
pp. 11454-11463
Author(s):  
Youngseok Kim ◽  
Dae Yeon Kim ◽  
Joung Sook Hong ◽  
Kyung Hyun Ahn
Keyword(s):  
Extensional Flow ◽  
Planar Extensional Flow

scholarly journals Ultrasensitive nucleic acid sequence detection by single-molecule electrophoresis

1996 ◽  
Author(s):  
A Castro ◽  
E.B. Shera
Keyword(s):  
Nucleic Acid ◽  
Single Molecule ◽  
Nucleic Acid Sequence ◽  
Sequence Detection
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