scholarly journals Near infrared-fluorescent and magnetic resonance imaging molecular probe with high T1 relaxivity for in vivo multimodal imaging

2010 ◽  
Vol 46 (21) ◽  
pp. 3705 ◽  
Author(s):  
Kevin Guo ◽  
Mikhail Y. Berezin ◽  
Jie Zheng ◽  
Walter Akers ◽  
Franck Lin ◽  
...  
2008 ◽  
pp. 5764 ◽  
Author(s):  
Takashi Jin ◽  
Yoshichika Yoshioka ◽  
Fumihiko Fujii ◽  
Yutaka Komai ◽  
Junji Seki ◽  
...  

Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 9264-9272 ◽  
Author(s):  
Gary Sitbon ◽  
Sophie Bouccara ◽  
Mariana Tasso ◽  
Aurélie Francois ◽  
Lina Bezdetnaya ◽  
...  

Cadmium-free quantum dots doped with Mn2+ions show promising results forin vivobimodal MRI and NIR fluorescence imaging.


2021 ◽  
Vol 22 (1) ◽  
pp. 160-172
Author(s):  
Kyohei Okubo ◽  
Ryuta Takeda ◽  
Shuhei Murayama ◽  
Masakazu Umezawa ◽  
Masao Kamimura ◽  
...  

2022 ◽  
Author(s):  
Doan Thi Kim Dung ◽  
Masakazu Umezawa ◽  
Kazunobu Ohnuki ◽  
Karina Nigoghossian ◽  
Kyohei Okubo ◽  
...  

Multimodal imaging can provide multidimensional information for understanding concealed microstructures or bioprocesses in biological objects. The combination of over–1000 nm near–infrared (OTN–NIR) fluorescence imaging and magnetic resonance (MR) imaging is...


2018 ◽  
Vol 35 (9) ◽  
pp. 1800208 ◽  
Author(s):  
Fengshou Wu ◽  
Jingwen Chen ◽  
Zhicong Li ◽  
Huifang Su ◽  
Ken Cham-Fai Leung ◽  
...  

Nanoscale ◽  
2018 ◽  
Vol 10 (22) ◽  
pp. 10699-10704 ◽  
Author(s):  
Jiao-Jiao Ma ◽  
Ming-Xia Yu ◽  
Zheng Zhang ◽  
Wei-Guo Cai ◽  
Zhi-Ling Zhang ◽  
...  

Near-infrared (NIR) fluorescent quantum dots (QDs) are ideal platforms to fabricate multifunctional contrast agents for multimodal imaging.


2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
William M. Payne ◽  
Tanner K. Hill ◽  
Denis Svechkarev ◽  
Megan B. Holmes ◽  
Balasrinivasa R. Sajja ◽  
...  

Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7.5, a near infrared fluorophore. To evaluate the relationship between MR and fluorescence signal from SAMINs, we employed simulated surgical phantoms that are routinely used to evaluate the depth at which near infrared (NIR) imaging agents can be detected by FIGS. Finally, imaging agent efficacy was evaluated in a human breast tumor xenograft model in nude mice, which demonstrated contrast in both fluorescence and magnetic resonance imaging.


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