An easy way to the preparation of multi-miktoarm star block copolymers via sequential double click reactions

2010 ◽  
Vol 1 (5) ◽  
pp. 621 ◽  
Author(s):  
Aydan Dag ◽  
Hakan Durmaz ◽  
Volkan Kirmizi ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Block Copolymers ◽  
Click Reactions ◽  
Miktoarm Star ◽  
Star Block Copolymers

Preparation of miktoarm star-block copolymers PSn-b-PVAc4-n via combination of ATRP and RAFT polymerization

2010 ◽  
Vol 48 (22) ◽  
pp. 5180-5188 ◽  
Author(s):  
Yansheng Qiu ◽  
Wei Zhang ◽  
Yuefang Yan ◽  
Jian Zhu ◽  
Zhengbiao Zhang ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Raft Polymerization ◽  
Miktoarm Star ◽  
Star Block Copolymers

I5S Miktoarm Star Block Copolymers:  Packing Constraints on Morphology and Discontinuous Chevron Tilt Grain Boundaries

2001 ◽  
Vol 34 (26) ◽  
pp. 9069-9073 ◽  
Author(s):  
Lizhang Yang ◽  
Sheng Hong ◽  
Samuel P. Gido ◽  
Gabriel Velis ◽  
Nikos Hadjichristidis
Keyword(s):  
Block Copolymers ◽  
Grain Boundaries ◽  
Miktoarm Star ◽  
Star Block Copolymers

Synthesis and properties of clickable A(B-b-C)20 miktoarm star-shaped block copolymers with a terminal alkyne group

2015 ◽  
Vol 6 (21) ◽  
pp. 3913-3917 ◽  
Author(s):  
Bing Huang ◽  
Min Chen ◽  
Shuxue Zhou ◽  
Limin Wu
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Terminal Alkyne ◽  
Click Reactions ◽  
Miktoarm Star

A novel and reactive A(B-b-C)20 miktoarm star-shaped block copolymer has been successfully synthesized through ATRP reaction combined with click reactions.

Influence of Macromolecular Architecture on the Crystallization of (PCL2)-b-(PS2) 4-Miktoarm Star Block Copolymers in Comparison to Linear PCL-b-PS Diblock Copolymer Analogues

2009 ◽  
Vol 42 (21) ◽  
pp. 8353-8364 ◽  
Author(s):  
A. T. Lorenzo ◽  
A. J. Müller ◽  
Ming-Champ Lin ◽  
Hsin-Lung Chen ◽  
U-Ser Jeng ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Diblock Copolymer ◽  
Miktoarm Star ◽  
Star Block Copolymers ◽  
Macromolecular Architecture

One-pot synthesis of star-block copolymers using double click reactions

2008 ◽  
Vol 46 (21) ◽  
pp. 7091-7100 ◽  
Author(s):  
Hakan Durmaz ◽  
Aydan Dag ◽  
Alp Hizal ◽  
Gurkan Hizal ◽  
Umit Tunca
Keyword(s):  
Block Copolymers ◽  
One Pot ◽  
Click Reactions ◽  
One Pot Synthesis ◽  
Star Block Copolymers

Biodegradable micelles self-assembled from miktoarm star block copolymers for MTX delivery

2015 ◽  
Vol 293 (8) ◽  
pp. 2291-2300 ◽  
Author(s):  
Qing-Han Zhou ◽  
Juan Lin ◽  
Li-Dong Li ◽  
Le Shang
Keyword(s):  
Block Copolymers ◽  
Miktoarm Star ◽  
Self Assembled ◽  
Star Block Copolymers

scholarly journals Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

Materials ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 3713
Author(s):  
Kalyan Ramesh ◽  
Avnish Kumar Mishra ◽  
Jin Kon Kim ◽  
Yeon Tae Jeong ◽  
Yeong-Soon Gal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Gel Permeation Chromatography ◽  
Critical Micellar Concentration ◽  
Anticancer Drug Delivery ◽  
Miktoarm Star ◽  
Star Block Copolymers

Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM2 miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.

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