scholarly journals Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

Materials ◽  
2020 ◽  
Vol 13 (17) ◽  
pp. 3713
Author(s):  
Kalyan Ramesh ◽  
Avnish Kumar Mishra ◽  
Jin Kon Kim ◽  
Yeon Tae Jeong ◽  
Yeong-Soon Gal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Gel Permeation Chromatography ◽  
Critical Micellar Concentration ◽  
Anticancer Drug Delivery ◽  
Miktoarm Star ◽  
Star Block Copolymers

Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM2 miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.

Synthesis, characterization, and property of biodegradable PEG-PCL-PLA terpolymers with miktoarm star and triblock architectures as drug carriers

2018 ◽  
Vol 32 (8) ◽  
pp. 1139-1152 ◽  
Author(s):  
Yixin Zhang ◽  
Song Luo ◽  
Yan Liang ◽  
Hai Zhang ◽  
Xinyu Peng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Laser Scanning ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Drug Carriers ◽  
Polymeric Micelle ◽  
Laser Scanning Microscopy ◽  
Confocal Laser ◽  
Miktoarm Star

A series of amphiphilic terpolymers with miktoarm star and triblock architectures of poly(ethylene glycol) (PEG), poly(ε-caprolactone) (PCL) and poly(l-lactide acid) (PLLA) or poly(DL-lactide acid) (PDLLA) terpolymers were synthesized as carriers for drug delivery. The architecture, molecular weight and crystallization behavior of the terpolymers were characterized. Anticancer drug doxorubicin was encapsulated in the micelles to investigate their drug loading properties. The miktoarm star terpolymers exhibited stronger crystallization capability, smaller size and better stability than that of triblock polymeric micelle, owing to the lower CMC values of miktoarm star polymeric micelle. Furthermore, the drug-loaded miktoarm star polymeric micelles showed the cumulative DOX release account of the micelles with PDLLA blocks was 65.3% while the release account of the corresponding micelles containing PLLA blocks was 45.2%. The IC50 values of drug-loaded miktoarm star polymeric micelle were lower than triblock polymeric micelle. Meanwhile, Confocal laser scanning microscopy (CLSM) and Flow Cytometry results demonstrated that the miktoarm star micelles were more favorable for cellular internalization. The miktoarm star micelles with PDLLA blocks were promising carriers for anticancer drug delivery.

Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery

2017 ◽  
Vol 60 ◽  
pp. 244-255 ◽  
Author(s):  
Jiao Guan ◽  
Zun-Qiang Zhou ◽  
Mao-Hua Chen ◽  
Hui-Yan Li ◽  
Da-Nian Tong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Target Cell ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Anticancer Drug Delivery

Novel self-assembled amphiphilic mPEGylated starch-deoxycholic acid polymeric micelles with pH-response for anticancer drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55139-55149 ◽  
Author(s):  
Jinlong Yang ◽  
Chunmei Gao ◽  
Shaoyu Lü ◽  
Xinggang Wang ◽  
Mingjia Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Deoxycholic Acid ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Ph Response ◽  
Self Assembled

Facile Fabrication of Thermo-Responsive and Reduction-Sensitive Polymeric Micelles for Anticancer Drug Delivery

2012 ◽  
Vol 12 (5) ◽  
pp. 703-711 ◽  
Author(s):  
Xulin Jiang ◽  
Lihua Li ◽  
Jia Liu ◽  
Wim E. Hennink ◽  
Renxi Zhuo
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Facile Fabrication

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

2015 ◽  
Vol 3 (7) ◽  
pp. 1105-1113 ◽  
Author(s):  
Rong Sun ◽  
Xiao-Jiao Du ◽  
Chun-Yang Sun ◽  
Song Shen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polylactic Acid ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

Synthesis of polymeric micelles with dual-functional sheddable PEG stealth for enhanced tumor-targeted drug delivery

2020 ◽  
Vol 11 (27) ◽  
pp. 4469-4476 ◽  
Author(s):  
Lu Sun ◽  
Hua Wei ◽  
Xianshuo Zhang ◽  
Chao Meng ◽  
Guiying Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Dual Functional ◽  
Targeted Drug

We reported the synthesis of polymeric micelles with a dual-functional sheddable mPEG stealth to realize simultaneously tumor-triggered targeting and intracellular micelle destabilization for enhanced anticancer drug delivery.

Enzyme-responsive polymeric micelles with fluorescence fabricated through aggregation-induced copolymer self-assembly for anticancer drug delivery

2020 ◽  
Vol 11 (48) ◽  
pp. 7704-7713
Author(s):  
Ke Yan ◽  
Shujing Zhang ◽  
Kun Zhang ◽  
Yalei Miao ◽  
Yudian Qiu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Anticancer Drug Delivery ◽  
Hydrophobic Chain

The TPE moiety with AIE is employed as functional hydrophobic chain to induce copolymer self-assembly and form polymeric micelle that can show enzyme-responsive drug delivery.

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