Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter

2012 ◽  
Vol 48 (79) ◽  
pp. 9936 ◽  
Author(s):  
Ryo Shintani ◽  
Tomoaki Ito ◽  
Midori Nagamoto ◽  
Haruka Otomo ◽  
Tamio Hayashi
Keyword(s):  
Asymmetric Synthesis ◽  
Quaternary Carbon ◽  
Palladium Catalyzed

ChemInform Abstract: Palladium-Catalyzed Asymmetric Synthesis of 2-Pyrrolidinones with a Quaternary Carbon Stereocenter.

ChemInform ◽  
2013 ◽  
Vol 44 (3) ◽  
pp. no-no
Author(s):  
Ryo Shintani ◽  
Tomoaki Ito ◽  
Midori Nagamoto ◽  
Haruka Otomo ◽  
Tamio Hayashi
Keyword(s):  
Asymmetric Synthesis ◽  
Quaternary Carbon ◽  
Palladium Catalyzed

Synthesis of fluorinated donepezil by palladium-catalyzed decarboxylative allylation of α-fluoro-β-keto ester with tri-substituted heterocyclic alkene and the self-disproportionation of its enantiomers

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85058-85062 ◽  
Author(s):  
Mayaka Maeno ◽  
Hiroya Kondo ◽  
Etsuko Tokunaga ◽  
Norio Shibata
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Asymmetric Synthesis ◽  
Therapeutic Agent ◽  
The Self ◽  
Keto Ester ◽  
Catalytic Asymmetric Synthesis ◽  
Palladium Catalyzed ◽  
Catalytic Asymmetric ◽  
Decarboxylative Allylation

Catalytic asymmetric synthesis of fluorinated donepezil, a promising new therapeutic agent for Alzheimer's disease, was achieved.

Central–axial–central chirality transfer: asymmetric synthesis of highly substituted indenes bearing a stereogenic quaternary carbon center from optically active propargyl alcohols

2015 ◽  
Vol 51 (2) ◽  
pp. 380-383 ◽  
Author(s):  
Masahiro Egi ◽  
Kaori Shimizu ◽  
Marin Kamiya ◽  
Yuya Ota ◽  
Shuji Akai
Keyword(s):  
Asymmetric Synthesis ◽  
Optically Active ◽  
Quaternary Carbon ◽  
Chirality Transfer ◽  
Propargyl Alcohols

An asymmetric synthesis of highly substituted indenes has been developed via the central–axial–central chirality transfer from optically active propargyl alcohols.

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