Kinetico-mechanistic studies of cyclometalating C–H bond activation reactions on Pd(ii) and Rh(ii) centres: The importance of non-innocent acidic solvents in the process

2012 ◽  
Vol 41 (37) ◽  
pp. 11243 ◽  
Author(s):  
Jaume Granell ◽  
Manuel Martínez
Keyword(s):  
Bond Activation ◽  
Mechanistic Studies ◽  
Acidic Solvents

Nickel-Catalyzed Hydroalkenylation of Alkynes through C–F Bond Activation: Synthesis of 2-Fluoro-1,3-dienes

Synthesis ◽  
2017 ◽  
Vol 49 (16) ◽  
pp. 3569-3575 ◽  
Author(s):  
Junji Ichikawa ◽  
Yota Watabe ◽  
Kohei Kanazawa ◽  
Takeshi Fujita
Keyword(s):  
Bond Activation ◽  
Oxidative Cyclization ◽  
Coupling Reactions ◽  
Mechanistic Studies ◽  
Co Catalyst

2-Fluoro-1,3-dienes were synthesized through nickel-catalyzed coupling reactions between β,β-difluorostyrenes and alkynes in the presence of ZrF4 as co-catalyst and a hydride source derived from triethylborane and lithium isopropoxide. Mechanistic studies revealed that the carbon–fluorine bond was cleaved by β-fluorine elimination from intermediary nickelacyclopentenes generated through oxidative cyclization of the two substrates.

ChemInform Abstract: Ruthenium-Catalyzed Oxidative Coupling of Primary Amines with Internal Alkynes Through C-H Bond Activation: Scope and Mechanistic Studies.

ChemInform ◽  
2015 ◽  
Vol 46 (39) ◽  
pp. no-no
Author(s):  
Sara Ruiz ◽  
Pedro Villuendas ◽  
Manuel A. Ortuno ◽  
Agusti Lledos ◽  
Esteban P. Urriolabeitia
Keyword(s):  
Oxidative Coupling ◽  
Bond Activation ◽  
Primary Amines ◽  
Mechanistic Studies ◽  
Internal Alkynes

scholarly journals Catalytic Benzolactamization Through Isonitrile Insertion Enabled 1,4-Palladium Shift

2021 ◽  
Author(s):  
Fulin Zhang ◽  
Ruihua Zhao ◽  
Lei Zhu ◽  
Yinghua Yu ◽  
Saihu Liao ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Heterocyclic Compounds ◽  
Bond Activation ◽  
Bond Formation ◽  
Bioactive Molecules ◽  
Mechanistic Studies ◽  
Carbon And Nitrogen ◽  
New Methods ◽  
Novel Approach ◽  
Bicyclic System

<b>Isoindolinone is a class of versatile <i>N</i>-heterocycles embedded in many bioactive molecules and natural products. The invention of new methods to synthesize these heterocyclic compounds with easily accessible chemicals is always attractive. Herein, a conceptually novel approach to access this bicyclic system via isonitrile insertion enabled 1,4-pallaidum shift is described. Compared with conventional isonitrile participated C-H bond activation, both carbon and nitrogen atoms in isonitrile moiety are engaged in new bond formation. Notably, two different isoindolinones can be obtained selectively by switching the bases employed. Mechanistic studies including DFT calculations have shed lights on the reaction mechanism and explained the selectivity led to different products. Moreover, the power of current benzolactamization is further demonstrated by providing concise routes to key intermediates of indoprofen, indobufen, aristolactams, lennoxamine and falipamil.</b>

Kinetico-mechanistic studies on CX (X=H, F, Cl, Br, I) bond activation reactions on organoplatinum(II) complexes

2014 ◽  
Vol 279 ◽  
pp. 115-140 ◽  
Author(s):  
Margarita Crespo ◽  
Manuel Martínez ◽  
S. Masoud Nabavizadeh ◽  
Mehdi Rashidi
Keyword(s):  
Bond Activation ◽  
Mechanistic Studies

scholarly journals Catalytic Benzolactamization Through Isonitrile Insertion Enabled 1,4-Palladium Shift

2021 ◽  
Author(s):  
Fulin Zhang ◽  
Ruihua Zhao ◽  
Lei Zhu ◽  
Yinghua Yu ◽  
Saihu Liao ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Heterocyclic Compounds ◽  
Bond Activation ◽  
Bond Formation ◽  
Bioactive Molecules ◽  
Mechanistic Studies ◽  
Carbon And Nitrogen ◽  
New Methods ◽  
Novel Approach ◽  
Bicyclic System

<b>Isoindolinone is a class of versatile <i>N</i>-heterocycles embedded in many bioactive molecules and natural products. The invention of new methods to synthesize these heterocyclic compounds with easily accessible chemicals is always attractive. Herein, a conceptually novel approach to access this bicyclic system via isonitrile insertion enabled 1,4-pallaidum shift is described. Compared with conventional isonitrile participated C-H bond activation, both carbon and nitrogen atoms in isonitrile moiety are engaged in new bond formation. Notably, two different isoindolinones can be obtained selectively by switching the bases employed. Mechanistic studies including DFT calculations have shed lights on the reaction mechanism and explained the selectivity led to different products. Moreover, the power of current benzolactamization is further demonstrated by providing concise routes to key intermediates of indoprofen, indobufen, aristolactams, lennoxamine and falipamil.</b>

Scope and Mechanistic Studies of Intramolecular Aliphatic C−H Bond Activation of N-Heterocyclic Carbene Iridium Complexes§

2007 ◽  
Vol 26 (18) ◽  
pp. 4618-4626 ◽  
Author(s):  
Yusuke Tanabe ◽  
Fumihiro Hanasaka ◽  
Ken-ichi Fujita ◽  
Ryohei Yamaguchi
Keyword(s):  
Bond Activation ◽  
Iridium Complexes ◽  
Mechanistic Studies

Reactions of Electrophiles with the Phosphaalkene Mes*PCH2:  Mechanistic Studies of a Catalytic Intramolecular C−H Bond Activation Reaction

2002 ◽  
Vol 21 (6) ◽  
pp. 1008-1010 ◽  
Author(s):  
Chi-Wing Tsang ◽  
Crystal A. Rohrick ◽  
Tejindra S. Saini ◽  
Brian O. Patrick ◽  
Derek P. Gates
Keyword(s):  
Bond Activation ◽  
Mechanistic Studies ◽  
Activation Reaction

Kinetico-Mechanistic Studies on Intramolecular C–X Bond Activation (X = Br, Cl) of Amino-Imino Ligands on Pt(II) Compounds. Prevalence of a Concerted Mechanism in Nonpolar, Polar, and Ionic Liquid Media

2012 ◽  
Vol 31 (11) ◽  
pp. 4367-4373 ◽  
Author(s):  
Teresa Calvet ◽  
Margarita Crespo ◽  
Mercè Font-Bardía ◽  
Susanna Jansat ◽  
Manuel Martínez
Keyword(s):  
Ionic Liquid ◽  
Bond Activation ◽  
Mechanistic Studies ◽  
Liquid Media ◽  
Concerted Mechanism
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