Inclusion phenomena of glycine-conjugated bile acids and the crystal structure of 1 : 1 complex of glycodeoxycholic acid and tetrahydrofuran

1994 ◽  
pp. 905 ◽  
Author(s):  
Kazuki Sada ◽  
Takuya Kitamura ◽  
Mikiji Miyata
Keyword(s):  
Crystal Structure ◽  
Bile Acids ◽  
Inclusion Phenomena ◽  
Glycodeoxycholic Acid ◽  
Conjugated Bile Acids

scholarly journals Microencapsulated Genetically EngineeredLactobacillus plantarum80 (pCBH1) for Bile Acid Deconjugation and Its Implication in Lowering Cholesterol

2004 ◽  
Vol 2004 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Mitchell Lawrence Jones ◽  
Hongmei Chen ◽  
Wei Ouyang ◽  
Terrence Metz ◽  
Satya Prakash
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Lactobacillus Plantarum ◽  
Blood Cholesterol ◽  
Bile Salt Hydrolase ◽  
Regular Exercise ◽  
Bile Acid Sequestrants ◽  
Oral Doses ◽  
Glycodeoxycholic Acid ◽  
Conjugated Bile Acids

Cholesterol is known to be a major risk factor for coronary heart disease (CHD). Current treatments for elevated blood cholesterol include dietary management, regular exercise, and drug therapy with fibrates, bile acid sequestrants, and statins. Such therapies, however, are often suboptimal and carry a risk for serious side effects. This study shows that microencapsulatedLactobacillus plantarum80 (pCBH1) cells can efficiently break down and remove bile acids, and establishes a basis for their use in lowering blood serum cholesterol. Results show that microencapsulated LP80 (pCBH1) is able to effectively break down the conjugated bile acids glycodeoxycholic acid (GDCA) and taurodeoxycholic acid (TDCA) with bile salt hydrolase (BSH) activities of 0.19 and 0.08μmol DCA/mg CDW/h respectively. This article also summarizes the physiological interrelationship between bile acids and cholesterol and predicts the oral doses of microencapsulatedLactobacillus plantarum80 (pCBH1) cells required for lowering cholesterol.

Production of free bile acids by bacterial deconjugation from conjugated bile acids derived from peptone in a medium.

1996 ◽  
Vol 51 (4) ◽  
pp. 1043-1047
Author(s):  
Masami MOROTOMI ◽  
Yukiko SAKAITANI ◽  
Mikiko SATOU ◽  
Takuya TAKAHASHI ◽  
Takashi MAKINO
Keyword(s):  
Bile Acids ◽  
Free Bile Acids ◽  
Conjugated Bile Acids

scholarly journals Proton magnetic resonance assay of total and taurine-conjugated bile acids in bile

1999 ◽  
Vol 40 (10) ◽  
pp. 1920-1924
Author(s):  
Hiroki Ishikawa ◽  
Toshiaki Nakashima ◽  
Koji Inaba ◽  
Hironori Mitsuyoshi ◽  
Yoshiki Nakajima ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Bile Acids ◽  
Proton Magnetic Resonance ◽  
Conjugated Bile Acids

scholarly journals Chemical and biological analysis of active free and conjugated bile acids in animal bile using HPLC-ELSD and MTT methods

2010 ◽  
Vol 2 (1) ◽  
pp. 125-130 ◽  
Author(s):  
NING WANG ◽  
YIBIN FENG ◽  
TANG NING XIE ◽  
WEIWEI SU ◽  
MEIFEN ZHU ◽  
...  
Keyword(s):  
Bile Acids ◽  
Biological Analysis ◽  
Conjugated Bile Acids ◽  
Animal Bile
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