Simultaneous determination of methocarbamol and aspirin binary mixture in their combined tablets by derivative and ratio derivative spectrophotometry

2015 ◽  
Vol 7 (13) ◽  
pp. 5674-5681 ◽  
Author(s):  
M. Sharaf El-Din ◽  
M. Eid ◽  
Abdallah M. Zeid
Keyword(s):  
Binary Mixture ◽  
Simultaneous Determination ◽  
Dosage Form ◽  
Derivative Spectrophotometry ◽  
Spectrophotometric Methods ◽  
Ratio Derivative Spectrophotometry

Two simple and rapid spectrophotometric methods for the simultaneous determination of methocarbamol and aspirin in their combined dosage form.

scholarly journals Validated Spectrophotometric Methods for Simultaneous Determination of Food Colorants and Sweeteners

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Fatma Turak ◽  
Mahmure Ustun Ozgur
Keyword(s):  
Simultaneous Determination ◽  
Derivative Spectrophotometry ◽  
Zero Crossing ◽  
Spectrophotometric Methods ◽  
Accuracy And Precision ◽  
Chewing Gums ◽  
Third Derivative ◽  
Interday Precision ◽  
Ratio Derivative Spectrophotometry

Two simple spectrophotometric methods have been proposed for simultaneous determination of two colorants (Indigotin and Brilliant Blue) and two sweeteners (Acesulfame-K and Aspartame) in synthetic mixtures and chewing gums without any prior separation or purification. The first method, derivative spectrophotometry (ZCDS), is based on recording the first derivative curves (for Indigotin, Brillant Blue, and Acesulfame-K) and third-derivative curve (for Aspartame) and determining each component using the zero-crossing technique. The other method, ratio derivative spectrophotometry (RDS), depends on application ratio spectra of first- and third-derivative spectrophotometry to resolve the interference due to spectral overlapping. Both colorants and sweeteners showed good linearity, with regression coefficients of 0.9992–0.9999. The LOD and LOQ values ranged from 0.05 to 0.33 μgmL−1and from 0.06 to 0.47 μgmL−1, respectively. The intraday and interday precision tests produced good RSD% values (<0.81%); recoveries ranged from 99.78% to 100.67% for all two methods. The accuracy and precision of the methods have been determined, and the methods have been validated by analyzing synthetic mixtures containing colorants and sweeteners. Two methods were applied for the above combination, and satisfactory results were obtained. The results obtained by applying the ZCDS method were statistically compared with those obtained by the RDS method.

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