Trivalent galactosyl-functionalized mesoporous silica nanoparticles as a target-specific delivery system for boron neutron capture therapy

Nanoscale ◽  
2013 ◽  
Vol 5 (19) ◽  
pp. 9412 ◽  
Author(s):  
Chian-Hui Lai ◽  
Nien-Chu Lai ◽  
Yung-Jen Chuang ◽  
Fong-In Chou ◽  
Chia-Min Yang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Mesoporous Silica Nanoparticles ◽  
Neutron Capture Therapy ◽  
Functionalized Mesoporous Silica ◽  
Boron Neutron Capture

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

2018 ◽  
Author(s):  
Guillaume Vares ◽  
Vincent Jallet ◽  
Yoshitaka Matsumoto ◽  
Cedric Rentier ◽  
Kentaro Takayama ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Mesoporous Silica Nanoparticles ◽  
Alpha Particles ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

AbstractTreatment resistance, relapse and metastasis remain critical issues in some challenging cancers, such as chondrosarcomas. Boron-neutron Capture Therapy (BNCT) is a targeted radiation therapy modality that relies on the ability of boron atoms to capture low energy neutrons, yielding high linear energy transfer alpha particles. We have developed an innovative boron-delivery system for BNCT, composed of multifunctional fluorescent mesoporous silica nanoparticles (B-MSNs), grafted with an activatable cell penetrating peptide (ACPP) for improved penetration in tumors and with Gadolinium for magnetic resonance imaging (MRI)in vivo. Chondrosarcoma cells were exposedin vitroto an epithermal neutron beam after B-MSNs administration. BNCT beam exposure successfully induced DNA damage and cell death, including in radio-resistant ALDH+ cancer stem cells (CSCs), suggesting that BNCT using this system might be a suitable treatment modality for chondrosarcoma or other hard-to-treat cancers.

A dual-delivery system of pH-responsive chitosan-functionalized mesoporous silica nanoparticles bearing BMP-2 and dexamethasone for enhanced bone regeneration

2015 ◽  
Vol 3 (10) ◽  
pp. 2056-2066 ◽  
Author(s):  
Qi Gan ◽  
Jiaoyang Zhu ◽  
Yuan Yuan ◽  
Honglai Liu ◽  
Jiangchao Qian ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Bone Regeneration ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Synergistic Action ◽  
Ph Responsive ◽  
Functionalized Mesoporous Silica

A proton-triggered chitosan-MSNs ensemble is fabricated to simultaneously deliver dexamethasone and BMP-2. With the synergistic action of BMP-2 and Dex, this dual-delivery system can effectively enhance bone regeneration.

scholarly journals DDIS-20. NEW A6K BORON DRUG DELIVERY SYSTEM FOR CLINICAL APPLICATION OF BORON NEUTRON CAPTURE THERAPY (BNCT)

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi73-vi73
Author(s):  
Hiroyuki Michiue ◽  
Asami Fukunaga ◽  
Atsushi Fujimura ◽  
Kazuyo Igawa ◽  
Hideki Matsui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

Application of drug delivery system to boron neutron capture therapy for cancer

2008 ◽  
Vol 5 (4) ◽  
pp. 427-443 ◽  
Author(s):  
Hironobu Yanagië ◽  
Aya Ogata ◽  
Hirotaka Sugiyama ◽  
Masazumi Eriguchi ◽  
Shinichi Takamoto ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture
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