In situ growth of β-FeOOH nanorods on graphene oxide with ultra-high relaxivity for in vivo magnetic resonance imaging and cancer therapy

2013 ◽  
Vol 1 (20) ◽  
pp. 2582 ◽  
Author(s):  
Mei-Ling Chen ◽  
Li-Ming Shen ◽  
Shuai Chen ◽  
Hui Wang ◽  
Xu-Wei Chen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Graphene Oxide ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
In Situ Growth ◽  
Resonance Imaging ◽  
High Relaxivity

scholarly journals Bioluminescence and Magnetic Resonance Imaging of Macrophage Homing to Experimental Abdominal Aortic Aneurysms

2012 ◽  
Vol 11 (2) ◽  
pp. 7290.2011.00033 ◽  
Author(s):  
Noriyuki Miyama ◽  
Monica M. Dua ◽  
Geoffrey M. Schultz ◽  
Hisanori Kosuge ◽  
Masahiro Terashima ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Aortic Aneurysms ◽  
Blue Staining ◽  
High Signal ◽  
Resonance Imaging ◽  
Iron Oxide Particles ◽  
Abdominal Aortic

Macrophage infiltration is a prominent feature of abdominal aortic aneurysm (AAA) progression. We used a combined imaging approach with bioluminescence (BLI) and magnetic resonance imaging (MRI) to study macrophage homing and accumulation in experimental AAA disease. Murine AAAs were created via intra-aortic infusion of porcine pancreatic elastase. Mice were imaged over 14 days after injection of prepared peritoneal macrophages. For BLI, macrophages were from transgenic mice expressing luciferase. For MRI, macrophages were labeled with iron oxide particles. Macrophage accumulation during aneurysm progression was observed by in situ BLI and by in vivo 7T MRI. Mice were sacrificed after imaging for histologic analysis. In situ BLI ( n = 32) demonstrated high signal in the AAA by days 7 and 14, which correlated significantly with macrophage number and aortic diameter. In vivo 7T MRI ( n = 13) at day 14 demonstrated T2* signal loss in the AAA and not in sham mice. Immunohistochemistry and Prussian blue staining confirmed the presence of injected macrophages in the AAA. BLI and MRI provide complementary approaches to track macrophage homing and accumulation in experimental AAAs. Similar dual imaging strategies may aid the study of AAA biology and the evaluation of novel therapies.

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