A rapid response “Turn-On” fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging

A novel “Turn-On” fluorescent probe, quaternarized 4-pyridinyl-substituted BODIPY dye by incorporating a 5-nitrofuran moiety, was developed and applied for imaging the hypoxic status of tumor cells by the indirect detection of nitroreductase.

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A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

RSC Advances ◽

10.1039/c4ra10044a ◽

2014 ◽

Vol 4 (99) ◽

pp. 56207-56210 ◽

Cited By ~ 33

Author(s):

Jun Yuan ◽

Yu-Qiong Xu ◽

Nan-Nan Zhou ◽

Rui Wang ◽

Xu-Hong Qian ◽

...

Keyword(s):

Tumor Cell ◽

Fluorescent Probe ◽

Cell Imaging ◽

Turn On ◽

Hypoxic Tumor

A selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized.

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A cyanine-derived “turn-on” fluorescent probe for imaging nitroreductase in hypoxic tumor cells

Analytical Methods ◽

10.1039/c5ay02312b ◽

2015 ◽

Vol 7 (24) ◽

pp. 10125-10128 ◽

Cited By ~ 19

Author(s):

Cong Xue ◽

Yingjie Lei ◽

Sichun Zhang ◽

Yaowu Sha

Keyword(s):

Tumor Cells ◽

Fluorescent Probe ◽

Phenol Group ◽

Turn On ◽

Hypoxic Tumor

A new “turn-on” fluorescent probe, composed of a protected phenol group with ap-nitrobenzyl moiety that functions as a latent donor and conjugated with two benzo[f]indolinium acceptors, was developed and applied for imaging nitroreductase (NTR) in hypoxic tumor cells.

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Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one

Analytical Chemistry ◽

10.1021/ac400750r ◽

2013 ◽

Vol 85 (8) ◽

pp. 3926-3932 ◽

Cited By ~ 150

Author(s):

Zhao Li ◽

Xiaohua Li ◽

Xinghui Gao ◽

Yangyang Zhang ◽

Wen Shi ◽

...

Keyword(s):

Tumor Cell ◽

Fluorescent Probe ◽

Cell Imaging ◽

Hypoxic Tumor

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Selective turn-on near-infrared fluorescence probe for hypoxic tumor cell imaging

RSC Advances ◽

10.1039/c7ra01466j ◽

2017 ◽

Vol 7 (30) ◽

pp. 18217-18223 ◽

Cited By ~ 4

Author(s):

Chen Jin ◽

Qiumeng Zhang ◽

Wei Lu

Keyword(s):

Tumor Cell ◽

Near Infrared ◽

Cell Imaging ◽

Fluorescence Probe ◽

Ether Linkage ◽

Near Infrared Fluorescence ◽

Turn On ◽

Hypoxic Tumor

In this study, we designed a new selective turn on near-infrared fluorescence probe by conjugating (1-methyl-2-nitro-1H-imidazol-5-yl)methanol to DCPO with ether linkage for hypoxic tumor cell imaging.

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A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging

Chemistry - An Asian Journal ◽

10.1002/asia.201600945 ◽

2016 ◽

Vol 11 (20) ◽

pp. 2918-2923 ◽

Cited By ~ 26

Author(s):

Xue You ◽

Lihong Li ◽

Xiaohua Li ◽

Huimin Ma ◽

Guanxin Zhang ◽

...

Keyword(s):

Tumor Cell ◽

Fluorescent Probe ◽

Cell Imaging ◽

Hypoxic Tumor

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A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells

The Analyst ◽

10.1039/c6an00369a ◽

2016 ◽

Vol 141 (10) ◽

pp. 2879-2882 ◽

Cited By ~ 21

Author(s):

Sihang Luo ◽

Yingchao Liu ◽

Feiyi Wang ◽

Qiang Fei ◽

Ben Shi ◽

...

Keyword(s):

Cancer Cells ◽

Tumor Cells ◽

Fluorescent Probe ◽

Reductive Cleavage ◽

Strong Fluorescence ◽

Turn On ◽

Hypoxic Tumor

A fluorescent probe localized in lysosomes after reductive cleavage with azoreductase gave strong fluorescence, providing specificity for imaging lysosomes in hypoxic cancer cells.

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