A cyanine-derived “turn-on” fluorescent probe for imaging nitroreductase in hypoxic tumor cells

2015 ◽  
Vol 7 (24) ◽  
pp. 10125-10128 ◽  
Author(s):  
Cong Xue ◽  
Yingjie Lei ◽  
Sichun Zhang ◽  
Yaowu Sha
Keyword(s):  
Tumor Cells ◽  
Fluorescent Probe ◽  
Phenol Group ◽  
Turn On ◽  
Hypoxic Tumor

A new “turn-on” fluorescent probe, composed of a protected phenol group with ap-nitrobenzyl moiety that functions as a latent donor and conjugated with two benzo[f]indolinium acceptors, was developed and applied for imaging nitroreductase (NTR) in hypoxic tumor cells.

A rapid response “Turn-On” fluorescent probe for nitroreductase detection and its application in hypoxic tumor cell imaging

The Analyst ◽  
2015 ◽  
Vol 140 (2) ◽  
pp. 574-581 ◽  
Author(s):  
Jian Xu ◽  
Shaobo Sun ◽  
Qian Li ◽  
Ying Yue ◽  
Yingdong Li ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Tumor Cells ◽  
Fluorescent Probe ◽  
Cell Imaging ◽  
Rapid Response ◽  
Indirect Detection ◽  
Turn On ◽  
Hypoxic Tumor

A novel “Turn-On” fluorescent probe, quaternarized 4-pyridinyl-substituted BODIPY dye by incorporating a 5-nitrofuran moiety, was developed and applied for imaging the hypoxic status of tumor cells by the indirect detection of nitroreductase.

A fluorescent turn-on probe for visualizing lysosomes in hypoxic tumor cells

The Analyst ◽  
2016 ◽  
Vol 141 (10) ◽  
pp. 2879-2882 ◽  
Author(s):  
Sihang Luo ◽  
Yingchao Liu ◽  
Feiyi Wang ◽  
Qiang Fei ◽  
Ben Shi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Fluorescent Probe ◽  
Reductive Cleavage ◽  
Strong Fluorescence ◽  
Turn On ◽  
Hypoxic Tumor

A fluorescent probe localized in lysosomes after reductive cleavage with azoreductase gave strong fluorescence, providing specificity for imaging lysosomes in hypoxic cancer cells.

scholarly journals A universal fluorogenic switch for Fe(ii) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells

2017 ◽  
Vol 8 (7) ◽  
pp. 4858-4866 ◽  
Author(s):  
Tasuku Hirayama ◽  
Hitomi Tsuboi ◽  
Masato Niwa ◽  
Ayaji Miki ◽  
Satoki Kadota ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Fluorescent Probe ◽  
Redox Equilibrium ◽  
Hypoxic Tumor ◽  
Equilibrium Shift ◽  
Labile Iron ◽  
Intracellular Redox

Oxygen-dependent fluctuation of labile Fe(ii) was visualized by a new N-oxide-based fluorescent probe for Fe(ii) ion.

A NIR turn-on fluorescent probe applied in cytochrome P450 reductase detection and hypoxia imaging in tumor cells

2017 ◽  
Vol 139 ◽  
pp. 587-592 ◽  
Author(s):  
Lei Cui ◽  
Yanping Shi ◽  
Shuping Zhang ◽  
Luliang Yan ◽  
Huan Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Tumor Cells ◽  
Fluorescent Probe ◽  
Cytochrome P450 Reductase ◽  
Hypoxia Imaging ◽  
Turn On ◽  
P450 Reductase

A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

RSC Advances ◽  
2014 ◽  
Vol 4 (99) ◽  
pp. 56207-56210 ◽  
Author(s):  
Jun Yuan ◽  
Yu-Qiong Xu ◽  
Nan-Nan Zhou ◽  
Rui Wang ◽  
Xu-Hong Qian ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Fluorescent Probe ◽  
Cell Imaging ◽  
Turn On ◽  
Hypoxic Tumor

A selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized.

scholarly journals A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells

2017 ◽  
Vol 12 (4) ◽  
pp. 1121-1132 ◽  
Author(s):  
Zhenhua Shen ◽  
Bijeta Prasai ◽  
Yuko Nakamura ◽  
Hisataka Kobayashi ◽  
Milcah S. Jackson ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Infrared Wavelength ◽  
Turn On ◽  
Cancer Tumor

A Boronic Acid-Based Fluorescence Hydrogel for Monosaccharide Detection

2018 ◽  
Author(s):  
Suying Xu ◽  
Adam Sedgwick ◽  
Souad Elfecky ◽  
Wenbo Chen ◽  
Ashley Jones ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Boronic Acid ◽  
Binding Constants ◽  
Strong Fluorescence ◽  
Fluorescence Response ◽  
Turn On ◽  
Fluorescence Turn On ◽  
Hydrogel System

<p>A boronic acid-based anthracene fluorescent probe was functionalised with an acrylamide unit to incorporate into a hydrogel system for monosaccharide detection<i>. </i>In solution, the fluorescent probe<b> </b>displayed a strong fluorescence turn-on response upon exposure to fructose, and an expected trend in apparent binding constants, as judged by a fluorescence response where D-fructose > D-galactose > D-mannose > D-glucose. The hydrogel incorporating the boronic acid monomer demonstrated the ability to detect monosaccharides by fluorescence with the same overall trend as the monomer in solution with the addition of fructose resulting in a 10-fold enhancement (≤ 0.25 M). <b><u></u></b></p>

Highly selective turn-on fluorescent probe for detection of cyanide in water and food materials

2019 ◽  
Vol 7 (2) ◽  
pp. 025003 ◽  
Author(s):  
Govindaraj Mahalakshmi ◽  
Paramasivam SaravanaKumar ◽  
Pandi RajaLakshmi ◽  
Muthu Seenivasaperumal ◽  
Kuppanagounder P Elango
Keyword(s):  
Fluorescent Probe ◽  
Turn On
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