MnII-containing coordination nanoparticles as highly efficient T1 contrast agents for magnetic resonance imaging

2014 ◽  
Vol 50 (51) ◽  
pp. 6740-6743 ◽  
Author(s):  
Gabriella Paul ◽  
Yoann Prado ◽  
Nada Dia ◽  
Eric Rivière ◽  
Sophie Laurent ◽  
...  

Nanoparticles of MnII-containing Prussian blue analogues reveal large longitudinal relaxivities exceeding that of clinical contrast agents.

Inorganics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 28 ◽  
Author(s):  
Irene Fernández-Barahona ◽  
María Muñoz-Hernando ◽  
Jesus Ruiz-Cabello ◽  
Fernando Herranz ◽  
Juan Pellico

Iron oxide nanoparticles have been extensively utilised as negative (T2) contrast agents in magnetic resonance imaging. In the past few years, researchers have also exploited their application as positive (T1) contrast agents to overcome the limitation of traditional Gd3+ contrast agents. To provide T1 contrast, these particles must present certain physicochemical properties with control over the size, morphology and surface of the particles. In this review, we summarise the reported T1 iron oxide nanoparticles and critically revise their properties, synthetic protocols and application, not only in MRI but also in multimodal imaging. In addition, we briefly summarise the most important nanoparticulate Gd and Mn agents to evaluate whether T1 iron oxide nanoparticles can reach Gd/Mn contrast capabilities.


2020 ◽  
Vol 3 (4) ◽  
pp. 3787-3797 ◽  
Author(s):  
Michele Mauri ◽  
Veronica Collico ◽  
Lucia Morelli ◽  
Pradip Das ◽  
Isabel García ◽  
...  

Nano Research ◽  
2014 ◽  
Vol 8 (4) ◽  
pp. 1259-1268 ◽  
Author(s):  
Rongli Cui ◽  
Juan Li ◽  
Huan Huang ◽  
Mingyi Zhang ◽  
Xihong Guo ◽  
...  

2019 ◽  
Vol 48 (31) ◽  
pp. 11882-11888 ◽  
Author(s):  
Wenlan Guan ◽  
Ji Ma ◽  
Xi Peng ◽  
Kezheng Chen

In order to unravel the relationship between zeta potential values and r2/r1 ratios for contrast agents in MRI application, a series of macroporous Prussian blue cubes were successfully synthesized by HCl etching and used as model samples for relaxivity investigation.


2016 ◽  
Vol 4 (41) ◽  
pp. 6716-6725 ◽  
Author(s):  
Yi Cao ◽  
Min Liu ◽  
Kunchi Zhang ◽  
Jingjin Dong ◽  
Guangyue Zu ◽  
...  

Macromolecular contrast agents (CAs) labeled with targeting molecules are gaining remarkable interest as promising materials overcoming the defects of small-molecule CAs.


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