A bromine-radical mediated three-component reaction comprising allenes, electron-deficient alkenes and allyl bromides: facile synthesis of 2-bromo-1,7-dienes

2014 ◽  
Vol 50 (45) ◽  
pp. 5993-5996 ◽  
Author(s):  
Takashi Kippo ◽  
Ilhyong Ryu
Keyword(s):  
Coupling Reaction ◽  
Facile Synthesis ◽  
Three Component Reaction ◽  
High Yields ◽  
Three Component Coupling

A bromine-radical mediated three-component coupling reaction was effectively achieved by the use of allenes, electron-deficient alkenes, and allyl bromides and led to the synthesis of 2-bromo-1,7-dienes in good to high yields.

scholarly journals PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

2011 ◽  
Vol 7 ◽  
pp. 1334-1341 ◽  
Author(s):  
Sanny Verma ◽  
Suman L Jain ◽  
Bir Sain
Keyword(s):  
Coupling Reaction ◽  
Recyclable Catalyst ◽  
Efficient Synthesis ◽  
Molecular Bromine ◽  
Keto Ester ◽  
One Step ◽  
High Yields ◽  
Multicomponent Coupling ◽  
Three Component Coupling

PEG-embedded potassium tribromide ([K+PEG]Br3 −) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester. At the end of the reaction the [K+PEG]Br3 − was readily regenerated from the reaction mixture by treating the residue containing [K+PEG]Br− with molecular bromine.

scholarly journals A Facile Synthesis of Polysubstituted Pyrroles by One-Pot Three-Component Reaction

2012 ◽  
Vol 9 (4) ◽  
pp. 2239-2244 ◽  
Author(s):  
Hossein Anaraki-Ardakani ◽  
Maziar Noei ◽  
Mina Karbalaei-Harofteh ◽  
Shahab Zomorodbakhsh
Keyword(s):  
Room Temperature ◽  
Facile Synthesis ◽  
One Pot ◽  
Pyrrole Derivatives ◽  
Dialkyl Acetylenedicarboxylates ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields ◽  
Neutral Conditions

A new and efficient one-pot synthesis of polysubstituted pyrrole derivatives by three-component reaction between dialkyl acetylenedicarboxylates, triphenylphosphine, 2-aminopyridin derivatives in the presence of arylglyoxals is described. The reactions were performed in dichloromethane at room temperature and neutral conditions and afforded high yields of products.

Facile Synthesis of (-)-Ascochlorin Using Palladium-Catalyzed Three Component Coupling Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (41) ◽  
Author(s):  
Makoto Aoki ◽  
Kenji Kawashima ◽  
Hirohisa Fujihara ◽  
Isao Shimizu
Keyword(s):  
Coupling Reaction ◽  
Facile Synthesis ◽  
Palladium Catalyzed ◽  
Three Component Coupling

A Simple and Economic Synthesis of Propargylamines by CuI-Catalyzed Three-Component Coupling Reaction with Succinic Acid as Additive

2009 ◽  
Vol 62 (1) ◽  
pp. 75 ◽  
Author(s):  
Gerui Ren ◽  
Jinli Zhang ◽  
Zheng Duan ◽  
Mengjun Cui ◽  
Yangjie Wu
Keyword(s):  
Succinic Acid ◽  
Efficient Method ◽  
Coupling Reaction ◽  
One Pot ◽  
Wide Range ◽  
High Yields ◽  
Three Component Coupling

A practical and efficient method was developed for the synthesis of propargylamines in a one-pot procedure from aldehydes, amines, and alkynes by using CuI as catalyst and succinic acid as additive. By using this protocol, a wide range of propargylamines was obtained in high yields.

scholarly journals Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines

2014 ◽  
Vol 10 ◽  
pp. 2065-2070 ◽  
Author(s):  
Praveen Reddy Adiyala ◽  
D Chandrasekhar ◽  
Jeevak Sopanrao Kapure ◽  
Chada Narsimha Reddy ◽  
Ram Awatar Maurya
Keyword(s):  
Environmental Impact ◽  
Coupling Reaction ◽  
Molecular Iodine ◽  
Atom Economy ◽  
Reaction Conditions ◽  
High Yields ◽  
Three Component Coupling

A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields.

Facile Synthesis of (−)-Ascochlorin Using Palladium-catalyzed Three Component Coupling Reaction

2007 ◽  
Vol 36 (5) ◽  
pp. 654-655 ◽  
Author(s):  
Makoto Aoki ◽  
Kenji Kawashima ◽  
Hirohisa Fujihara ◽  
Isao Shimizu
Keyword(s):  
Coupling Reaction ◽  
Facile Synthesis ◽  
Palladium Catalyzed ◽  
Three Component Coupling

C3 functionalization of indolizines via In(iii)-catalyzed three-component reaction

2015 ◽  
Vol 13 (45) ◽  
pp. 10986-10994 ◽  
Author(s):  
Youngeun Jung ◽  
Ikyon Kim
Keyword(s):  
Functional Groups ◽  
Coupling Reaction ◽  
New Class ◽  
Rapid Access ◽  
Three Component Reaction ◽  
Post Functionalization ◽  
Three Component Coupling

Post-functionalization at the C3 position of indolizines via In(iii)-catalyzed three-component coupling reaction with amines and aldehydes allowed rapid access to a new class of indolizines with diverse functional groups at the C3 position in good to excellent yields.

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