Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells

2014 ◽  
Vol 50 (94) ◽  
pp. 14724-14727 ◽  
Author(s):  
Ming Cheng ◽  
Wei Zhang ◽  
Jinghe Yuan ◽  
Wangxi Luo ◽  
Nan Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Single Molecule ◽  
Transforming Growth Factor ◽  
Living Cells ◽  
Unnatural Amino Acid ◽  
Type Ii ◽  
Site Specific ◽  
Single Molecule Dynamics ◽  
Factor Type ◽  
Molecule Dynamics

Single-molecule dynamics of the transforming growth factor type II receptor (TβRII) labeled by an unnatural amino acid.

Expression of transforming growth factor-? type II receptor mRNA in embryonic and adult rat kidney

Nephrology ◽  
1995 ◽  
Vol 1 (6) ◽  
pp. 547-553 ◽  
Author(s):  
Amander T CLARK ◽  
Miriam D FORD ◽  
Victor NURCOMBE ◽  
Daine ALCORN ◽  
Brian KEY ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Rat Kidney ◽  
Type Ii ◽  
Adult Rat ◽  
Receptor Mrna ◽  
Factor Type

Transforming Growth Factor-?? Type II Receptors and Smad Proteins in Follicular Thyroid Tumors

2000 ◽  
Vol 110 (8) ◽  
pp. 1323-1327 ◽  
Author(s):  
Jeff West ◽  
Teresita Munoz-Antonia ◽  
Jean G. Johnson ◽  
Douglas Klotch ◽  
Carlos A. Muro-Cacho
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Type Ii ◽  
Thyroid Tumors ◽  
Smad Proteins ◽  
Factor Type ◽  
Follicular Thyroid Tumors

scholarly journals Single-molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization

2009 ◽  
Vol 106 (37) ◽  
pp. 15679-15683 ◽  
Author(s):  
Wei Zhang ◽  
Yaxin Jiang ◽  
Qiang Wang ◽  
Xinyong Ma ◽  
Zeyu Xiao ◽  
...  
Keyword(s):  
Growth Factor ◽  
Single Molecule ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Receptor Activation ◽  
General Mechanism ◽  
Type Ii ◽  
Serine Threonine Kinase ◽  
Receptor Dimerization ◽  
Threonine Kinase

Transforming growth factor-β (TGF-β) elicits its signals through two transmembrane serine/threonine kinase receptors, type II (TβRII) and type I receptors. It is generally believed that the initial receptor dimerization is an essential event for receptor activation. However, previous studies suggested that TGF-β signals by binding to the preexisting TβRII homodimer. Here, using single molecule microscopy to image green fluorescent protein (GFP)-labeled TβRII on the living cell surface, we demonstrated that the receptor could exist as monomers at the low expression level in resting cells and dimerize upon TGF-β stimulation. This work reveals a model in which the activation of serine-threonine kinase receptors is also accomplished via dimerization of monomers, suggesting that receptor dimerization is a general mechanism for ligand-induced receptor activation.

scholarly journals Transforming growth factor-  type II receptor in pulmonary arteries of patients with very severe COPD

2006 ◽  
Vol 28 (3) ◽  
pp. 556-562 ◽  
Author(s):  
B. Beghe ◽  
E. Bazzan ◽  
S. Baraldo ◽  
F. Calabrese ◽  
F. Rea ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Pulmonary Arteries ◽  
Type Ii ◽  
Factor Type ◽  
Severe Copd
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