scholarly journals Autophagy, a major adaptation pathway shaping cancer cell death and anticancer immunity responses following photodynamic therapy

2015 ◽  
Vol 14 (8) ◽  
pp. 1410-1424 ◽  
Author(s):  
Abhishek D. Garg ◽  
Hannelore Maes ◽  
Erminia Romano ◽  
Patrizia Agostinis
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Cancer Biology ◽  
Cancer Cell Death ◽  
Adaptation Pathway ◽  
Anticancer Immunity

Autophagy is fundamentally a cytoprotective and pro-survival process yet studies have shown that it has an exceedingly contextual role in cancer biology; depending on the phase, location or type of oncogenic trigger and/or therapy, its role could fluctuate from pro- to anti-tumourigenic.

scholarly journals Verteporfin- and sodium porfimer-mediated photodynamic therapy enhances pancreatic cancer cell death without activating stromal cells in the microenvironment

2019 ◽  
Vol 24 (11) ◽  
pp. 1 ◽  
Author(s):  
Jingjing Lu ◽  
Bhaskar Roy ◽  
Marlys Anderson ◽  
Cadman L. Leggett ◽  
Michael J. Levy ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Stromal Cells ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Death

Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit

2009 ◽  
Vol 280 (1) ◽  
pp. 101-109 ◽  
Author(s):  
Bartosz Ferens ◽  
Anna Kawiak ◽  
Bogdan Banecki ◽  
Krzysztof P. Bielawski ◽  
Joanna Zawacka-Pankau
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Tumor Suppressor ◽  
Enzymatic Activity ◽  
Cancer Cell ◽  
Tumor Suppressor Protein ◽  
Wild Type ◽  
Cancer Cell Death

scholarly journals Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 658 ◽  
Author(s):  
Rachel Riley ◽  
Rachel O’Sullivan ◽  
Andrea Potocny ◽  
Joel Rosenthal ◽  
Emily Day
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Gold Shell ◽  
Cancer Cell Death ◽  
Silica Core

Light-activated therapies are ideal for treating cancer because they are non-invasive and highly specific to the area of light application. Photothermal therapy (PTT) and photodynamic therapy (PDT) are two types of light-activated therapies that show great promise for treating solid tumors. In PTT, nanoparticles embedded within tumors emit heat in response to laser light that induces cancer cell death. In PDT, photosensitizers introduced to the diseased tissue transfer the absorbed light energy to nearby ground state molecular oxygen to produce singlet oxygen, which is a potent reactive oxygen species (ROS) that is toxic to cancer cells. Although PTT and PDT have been extensively evaluated as independent therapeutic strategies, they each face limitations that hinder their overall success. To overcome these limitations, we evaluated a dual PTT/PDT strategy for treatment of triple negative breast cancer (TNBC) cells mediated by a powerful combination of silica core/gold shell nanoshells (NSs) and palladium 10,10-dimethyl-5,15-bis(pentafluorophenyl)biladiene-based (Pd[DMBil1]-PEG750) photosensitizers (PSs), which enable PTT and PDT, respectively. We found that dual therapy works synergistically to induce more cell death than either therapy alone. Further, we determined that low doses of light can be applied in this approach to primarily induce apoptotic cell death, which is vastly preferred over necrotic cell death. Together, our results show that dual PTT/PDT using silica core/gold shell NSs and Pd[DMBil1]-PEG750 PSs is a comprehensive therapeutic strategy to non-invasively induce apoptotic cancer cell death.

Photodynamic therapy combined with acetylsalicylic acid: the mechanisms involved in colon and esophagus cancer cell death

2016 ◽  
Vol 61 ◽  
pp. S115
Author(s):  
N. Almeida ◽  
M. Laranjo ◽  
A. Serra ◽  
M. Abrantes ◽  
M. Pineiro ◽  
...  
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Acetylsalicylic Acid ◽  
Cancer Cell ◽  
Esophagus Cancer ◽  
Cancer Cell Death
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