A portable SERS method for the determination of uric acid using a paper-based substrate and multivariate curve resolution

The Analyst ◽  
2016 ◽  
Vol 141 (6) ◽  
pp. 1966-1972 ◽  
Author(s):  
Javier E. L. Villa ◽  
Ronei J. Poppi
Keyword(s):  
Raman Spectroscopy ◽  
Uric Acid ◽  
Gold Nanoparticle ◽  
Quantitative Method ◽  
Surface Enhanced Raman Spectroscopy ◽  
Multivariate Curve Resolution ◽  
Curve Resolution ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

This paper presents a portable quantitative method for the on-site determination of uric acid in urine using surface-enhanced Raman spectroscopy (SERS) and gold nanoparticle-coated paper as a substrate.

Multivariate Analysis Aided Surface-Enhanced Raman Spectroscopy (MVA-SERS) Multiplex Quantitative Detection of Trace Fentanyl in Illicit Drug Mixtures Using a Handheld Raman Spectrometer

2021 ◽  
pp. 000370282110329
Author(s):  
Ling Wang ◽  
Mario O. Vendrell-Dones ◽  
Chiara Deriu ◽  
Sevde Doğruer ◽  
Peter de B. Harrington ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Principal Component ◽  
Surface Enhanced Raman Spectroscopy ◽  
Quantitative Detection ◽  
Least Squares Regression ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Current Screening

Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. In this study, we present the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system. Our protocol is optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and can also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures is enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which allow for the determination of fentanyl as low as 0.05% in simulated seized heroin and 0.10% in simulated seized cocaine samples.

3D Imaging for Single Bacterial Cell Using Surface-enhanced Raman Spectroscopy with Multivariate Curve Resolution Model

The Analyst ◽  
2021 ◽  
Author(s):  
Wenjing Liu ◽  
Chuanbo Jing ◽  
Xiaowei Liu ◽  
Jingjing Du
Keyword(s):  
Raman Spectroscopy ◽  
Bacterial Cell ◽  
Single Cell Analysis ◽  
Surface Enhanced Raman Spectroscopy ◽  
Multivariate Curve Resolution ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Resolution Model ◽  
Genetic Mechanisms ◽  
Sers Imaging

Imaging biomolecules within the single bacterial cell is crucial for understanding cellular genetic mechanisms. Herein, we exploited a surface-enhanced Raman spectroscopy (SERS) imaging strategy for single cell analysis. The cellular...

Understanding the competitive interactions in aptamer–gold nanoparticle based colorimetric assays using surface enhanced Raman spectroscopy (SERS)

2016 ◽  
Vol 8 (7) ◽  
pp. 1602-1608 ◽  
Author(s):  
Shintaro Pang ◽  
Lili He
Keyword(s):  
Raman Spectroscopy ◽  
Gold Nanoparticle ◽  
Rapid Detection ◽  
Surface Enhanced Raman Spectroscopy ◽  
Competitive Interactions ◽  
Detection Methods ◽  
Color Changes ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Colorimetric Assays

Aptamer–gold nanoparticle (AuNP) based colorimetric assays have become increasingly popular as viable rapid detection methods, but the molecular interactions governing the mechanism and successful interpretation of color changes have not been explored well.

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