An optimization of the LC-MS/MS workflow for deep proteome profiling on an Orbitrap Fusion

2016 ◽  
Vol 8 (2) ◽  
pp. 425-434 ◽  
Author(s):  
Litong Nie ◽  
Mingrui Zhu ◽  
Shengnan Sun ◽  
Linhui Zhai ◽  
Zhixiang Wu ◽  
...  
Keyword(s):  
High Resolution ◽  
Proteomic Profiling ◽  
Post Translational Modification ◽  
Mass Spectrometers ◽  
Proteome Profiling ◽  
High Resolution Mass ◽  
Resolution Mass

The development of high-resolution mass spectrometers (MS) has greatly advanced the system-wide proteomic profiling and protein post-translational modification (PTM) studies.

Nanodust detection with Cassini CDA - Implications for DESTINY+ and Interstellar Probe

2021 ◽  
Author(s):  
Ralf Srama ◽  
Jon K. Hillier ◽  
Sean Hsu ◽  
Sascha Kempf ◽  
Masanori Kobayashi ◽  
...  
Keyword(s):  
High Resolution ◽  
Impact Ionization ◽  
Cosmic Dust ◽  
Hypervelocity Impact ◽  
Dust Particles ◽  
Interstellar Space ◽  
Mass Spectrometers ◽  
High Resolution Mass ◽  
Resolution Mass

<p>The Cosmic Dust Analyzer (CDA) onboard Cassini characterized successfully the dust environment at Saturn from 2004 to 2017. Besides the study of Saturn’s E ring and its interaction with the embedded moons, CDA detected nanoparticles in the outer Saturn system moving on unbound orbits and originating primarily from Saturn’s E-ring. Although the instrument was built to detect micron and sub-micron sized particles, nano-sized grains were detected during the flyby at early Jupiter and in the outer environment at Saturn. Fast dust particles with sizes below 10 nm were measured by in-situ impact ionization and mass spectra were recorded. What are the limits of in-situ hypervelocity impact detection and what can be expected with current high-resolution mass spectrometers as flown onboard the missions DESTINY+ or EUROPA? Is the sensitivity of Dust Telescopes sufficient to detect nano-diamonds in interstellar space? This presentation summarizes the current experience of in-situ dust detectors and gives a prediction for future missions. In summary, current Dust Telescopes with integrated high-resolution mass spectrometers are more sensitive than the CASSINI Cosmic Dust Analyzer.</p>

scholarly journals Proteomic profiling of retinoblastoma by high resolution mass spectrometry

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Ravikanth Danda ◽  
Kalaivani Ganapathy ◽  
Gajanan Sathe ◽  
Anil K. Madugundu ◽  
Sharavan Ramachandran ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Proteomic Profiling ◽  
High Resolution Mass ◽  
Resolution Mass

High-Resolution Mass Spectrometers

2008 ◽  
Vol 1 (1) ◽  
pp. 579-599 ◽  
Author(s):  
Alan G. Marshall ◽  
Christopher L. Hendrickson
Keyword(s):  
High Resolution ◽  
Mass Spectrometers ◽  
High Resolution Mass ◽  
Resolution Mass

THEORETICAL AND EXPERIMENTAL STUDY OF HIGH-MASS HIGH-RESOLUTION MASS SPECTROMETERS

1959 ◽  
pp. 44-65 ◽  
Author(s):  
H.G. VOORHIES ◽  
C.F. ROBINSON ◽  
L.G. HALL ◽  
W.M. BRUBAKER ◽  
C.E. BERRY
Keyword(s):  
Experimental Study ◽  
High Resolution ◽  
High Mass ◽  
Mass Spectrometers ◽  
High Resolution Mass ◽  
Resolution Mass

A small on-line computer system for high-resolution mass spectrometers

1970 ◽  
Vol 4 (S1) ◽  
pp. 17-39 ◽  
Author(s):  
R. J. Klimowski ◽  
R. Venkataraghavan ◽  
F. W. McLafferty ◽  
E. B. Delany
Keyword(s):  
High Resolution ◽  
Computer System ◽  
Mass Spectrometers ◽  
High Resolution Mass ◽  
On Line ◽  
Resolution Mass
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