Bis(zinc porphyrin) as a CD-sensitive bidentate host molecule: direct determination of absolute configuration of mono-alcohols

2015 ◽  
Vol 51 (55) ◽  
pp. 11068-11071 ◽  
Author(s):  
Satoshi Hayashi ◽  
Miku Yotsukura ◽  
Masahiro Noji ◽  
Toshikatsu Takanami
Keyword(s):  
Absolute Configuration ◽  
Direct Determination ◽  
Host Molecule ◽  
Zinc Porphyrin ◽  
Host System ◽  
System P ◽  
Determination Of Absolute Configuration ◽  
The Absolute ◽  
Circular Dichroic

A facile and direct protocol to determine the absolute configurations of chiral mono-alcohols without analyte derivatization can now be realized using a novel circular dichroic (CD)-sensitive bis(zinc porphyrin) BP1 host system.

(-)-Strempeliopine, stereoselective total synthesis and the determination of absolute configuration

1986 ◽  
Vol 51 (8) ◽  
pp. 1731-1742 ◽  
Author(s):  
Josef Hájíček ◽  
Jan Trojánek
Keyword(s):  
Circular Dichroism ◽  
Total Synthesis ◽  
Absolute Configuration ◽  
Determination Of Absolute Configuration ◽  
Natural Base ◽  
The Absolute ◽  
Circular Dichroïsm

A synthesis of (±)-strempeliopine (II) is described, the key step of which is the stereoselective reductive rearrangement of 18-methylene-1,2-dehydroaspidospermidine (XI). The absolute configuration of the natural (-)-base II was determined as (2S, 7R, 20R, 21R) on the basis of its synthesis from (+)-18-methylenevincadifformine (XVII) the configuration of which was derived from a comparison of circular dichroism properties of bases with a β-anilinoacrylate chromophore. The biogenesis of the alkaloids of the schizozygane type is discussed.

Direct Determination of Absolute Configuration of Methyl-Substituted Phenyloxiranes:  Combined Experimental and Theoretical Approach

2006 ◽  
Vol 110 (29) ◽  
pp. 9123-9129 ◽  
Author(s):  
Peter Fristrup ◽  
Peter R. Lassen ◽  
Christian Johannessen ◽  
David Tanner ◽  
Per-Ola Norrby ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
Theoretical Approach ◽  
Direct Determination ◽  
Determination Of Absolute Configuration

Determination of the absolute configuration of secondary alcohols by modified Horeau's method using HPLC

1989 ◽  
Vol 54 (1) ◽  
pp. 151-159 ◽  
Author(s):  
Aleš Svatoš ◽  
Irena Valterová ◽  
Anna Fábryová ◽  
Jan Vrkoč
Keyword(s):  
Absolute Configuration ◽  
Secondary Alcohols ◽  
Model Compounds ◽  
Defense Substance ◽  
Determination Of Absolute Configuration ◽  
The Absolute

A method for determination of absolute configuration of secondary alcohols, based on a modified Horeau's method, has been developed. The ratio of (1R,2'S)- and (1R,2'R)-N-[1-(1-naphthyl)-ethyl]-2-phenylbutanamides (V and VI, respectively) was determined by HPLC on a straight phase. The method was tested on a series of steroid and terpene model compounds and was used in the determination of absolute configuration of 15-ripperten-3α-ol (XV), the defense substance of Nasutitermes nigriceps termites. The sensibility of the determination is 100 nmol of the alcohol.

Direct determination of the absolute configuration of a cyclic thiolsulfinate by VCD spectroscopy

2003 ◽  
Vol 14 (15) ◽  
pp. 2267-2269 ◽  
Author(s):  
Anders Holmén ◽  
Joakim Oxelbark ◽  
Stig Allenmark
Keyword(s):  
Absolute Configuration ◽  
Direct Determination ◽  
The Absolute

F-THENA: a chiral derivatizing agent for the determination of the absolute configuration of secondary aromatic alcohols with a self-validating system

2016 ◽  
Vol 14 (46) ◽  
pp. 11002-11012 ◽  
Author(s):  
Kulvadee Dolsophon ◽  
Jakapun Soponpong ◽  
Jittra Kornsakulkarn ◽  
Chawanee Thongpanchang ◽  
Samran Prabpai ◽  
...  
Keyword(s):  
Absolute Configuration ◽  
H Nmr ◽  
System P ◽  
Aromatic Alcohols ◽  
Derivatizing Agent ◽  
Chiral Derivatizing Agent ◽  
The Absolute

F-THENA can be used with 19F- and 1H-NMR to assign the configuration of 2° aromatic alcohols with a self-validation system.

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