Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity

2015 ◽  
Vol 44 (28) ◽  
pp. 12640-12652 ◽  
Author(s):  
Hanna Lewandowska ◽  
Jarosław Sadło ◽  
Sylwia Męczyńska ◽  
Tomasz M. Stępkowski ◽  
Grzegorz Wójciuk ◽  
...  
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Genotoxic Effect ◽  
Iron Ions ◽  
Nitrosyl Complexes ◽  
Dinitrosyl Iron

Formation of glutathionyl nitrosyl complexes abolishes the in vitro genotoxic effect of iron ions alone and iron ions in the presence of a naturally abundant antioxidant, GSH.

Dinitrosyl Iron Complexes (DNICs) as Inhibitors of the SARS-CoV-2 Main Protease

2021 ◽  
Author(s):  
D. Chase Pectol ◽  
Christopher Ryan DeLaney ◽  
Jiyun Zhu ◽  
Drake M. Mellott ◽  
Ardala Katzfuss ◽  
...  
Keyword(s):  
In Silico ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Protease Inhibition ◽  
Main Protease ◽  
Dinitrosyl Iron ◽  
Protease Assay

By repurposing DNICs designed for other medicinal purposes, the possibility of protease inhibition was investigated in silico using AutoDock 4.2.6 (AD4) and in vitro via a FRET protease assay. AD4...

ДИНИТРОЗИЛЬНЫЕ КОМПЛЕКСЫ ЖЕЛЕЗА C ТИОЛСОДЕРЖАЩИМИ ЛИГАНДАМИ ПРЕДСТАВЛЕНЫ В ЖИВЫХ ОРГАНИЗМАХ В ОСНОВНОМ ИХ БИЯДЕРНОЙ ФОРМОЙ

2020 ◽  
Vol 65 (6) ◽  
pp. 1142-1153
Author(s):  
В.Д. Микоян ◽  
◽  
Е.Н. Бургова ◽  
Р.Р. Бородулин ◽  
А.Ф. Ванин ◽  
...  
Keyword(s):  
Electron Paramagnetic Resonance ◽  
Sodium Nitrite ◽  
Iron Complexes ◽  
Paramagnetic Resonance ◽  
First Case ◽  
Dinitrosyl Iron ◽  
Electron Paramagnetic ◽  
Dinitrosyl Complexes

The number of mononitrosyl iron complexes with diethyldithiocarbamate, formed in the liver of mice in vivo and in vitro after intraperitoneal injection of binuclear dinitrosyl iron complexes with N-acetyl-L-cysteine or glutathione, S-nitrosoglutathione, sodium nitrite or the vasodilating drug Isoket® was assessed by electron paramagnetic resonance (EPR). The number of the said complexes, in contrast to the complexes, formed after nitrite or Isoket administration, the level of which sharply increased after treatment of liver preparations with a strong reducing agent - dithionite, did not change in the presence of dithionite. It was concluded that, in the first case, EPR-detectable mononitrosyl iron complexes with diethyldithiocarbamate in the absence and presence of dithionite appeared as a result of the reaction of NO formed from nitrite with Fe2+-dieth- yldithiocarbamate and Fe3+-diethyldithiocarbamate complexes, respectively. In the second case, mononitrosyl iron complexes with diethyldithiocarbamate appeared as a result of the transition of iron-mononitosyl fragments from ready-made iron-dinitrosyl groups of binuclear dinitrosyl complexes, which is three to four times higher than the content of the mononuclear form of these complexes in the tissue...

Effect of Dinitrosyl Iron Complexes (NO Donors) on the Metabolic Processes of Human Fibroblasts

2018 ◽  
Vol 483 (4) ◽  
pp. 452-456
Author(s):  
A. Gizatullin ◽  
◽  
N. Akent'eva ◽  
N. Sanina ◽  
N. Shmatko ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Metabolic Processes ◽  
No Donors ◽  
Dinitrosyl Iron

The Influence of the Nature of the Ligand on the Antitumor Activity and Cytotoxic Effect of Binuclear Dinitrosyl Iron Complexes

BIOPHYSICS ◽  
2020 ◽  
Vol 65 (5) ◽  
pp. 863-868
Author(s):  
A. F. Vanin ◽  
L. A. Ostrovskaya ◽  
D. B. Korman ◽  
E. I. Nekrasova ◽  
O. O. Riabaya ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cytotoxic Effect ◽  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron

Re-examination of the formation of dinitrosyl–iron complexes during reaction of S-nitrosothiols with Fe(II)

2001 ◽  
Vol 318 (1-2) ◽  
pp. 1-7 ◽  
Author(s):  
Simona Costanzo ◽  
Stephane Ménage ◽  
Roberto Purrello ◽  
Raffaele P Bonomo* ◽  
Marc Fontecave*
Keyword(s):  
Iron Complexes ◽  
Dinitrosyl Iron Complexes ◽  
Dinitrosyl Iron
Sign in / Sign up

Export Citation Format

Share Document