Revisiting and re-engineering the classical zinc finger peptide: consensus peptide-1 (CP-1)

2016 ◽  
Vol 12 (4) ◽  
pp. 1183-1193 ◽  
Author(s):  
Angelique N. Besold ◽  
Leland R. Widger ◽  
Frances Namuswe ◽  
Jamie L. Michalek ◽  
Sarah L. J. Michel ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Consensus Peptide ◽  
Zinc Finger Peptide

Zinc plays key structural and catalytic roles in biology.

A consensus zinc finger peptide: design, high-affinity metal binding, a pH-dependent structure, and a His to Cys sequence variant

1991 ◽  
Vol 113 (12) ◽  
pp. 4518-4523 ◽  
Author(s):  
Beth Allyn Krizek ◽  
Barbara T. Amann ◽  
Valda J. Kilfoil ◽  
Denise L. Merkle ◽  
Jeremy M. Berg
Keyword(s):  
Zinc Finger ◽  
Metal Binding ◽  
Sequence Variant ◽  
Peptide Design ◽  
High Affinity ◽  
Ph Dependent ◽  
Zinc Finger Peptide

scholarly journals In vivo anti-influenza virus activity of a zinc finger peptide.

1997 ◽  
Vol 41 (3) ◽  
pp. 687-692 ◽  
Author(s):  
A K Judd ◽  
A Sanchez ◽  
D J Bucher ◽  
J H Huffman ◽  
K Bailey ◽  
...  
Keyword(s):  
Amino Acids ◽  
Influenza Virus ◽  
Amino Acid ◽  
Virus Infection ◽  
Zinc Finger ◽  
Matrix Protein ◽  
H3n2 Virus ◽  
Arterial Oxygen ◽  
Treatment Schedule ◽  
Zinc Finger Peptide

Matrix protein (M1) is a major structural protein of influenza virus, and it inhibits its own polymerase. A 19-amino-acid peptide, corresponding to a zinc finger region of the M1 sequence of influenza virus strain A/PR/8/34 (H1N1), centered around amino acids 148 to 166, was synthesized. This peptide, designated peptide 6, represents a zinc finger which includes a 7-amino-acid loop or finger and a 4-amino-acid tail at the carboxyl terminus, in addition to the 8 amino acids involved in the coordination of Zn. Three experiments were run to evaluate the activity of peptide 6 on infections induced in mice by influenza A/PR/8/34 and A/Victoria/3/75 (H3N2) viruses. Intranasal (i.n.) treatment of the H1N1 virus infection with 30 or 60 mg/kg of body weight/day, three times daily for 5 days, beginning 4 h pre-or 8 h post-virus exposure, was effective in preventing death, reducing the arterial oxygen decline, and inhibiting lung consolidation. Virus titers in the lungs determined on day 5 were reduced by up to 1.5 log10 in treated groups, but considerable variation in the titers of the recovered virus was seen. The H3N2 virus infection was treated i.n. with 30, 60, or 120 mg of peptide 6/kg/day by using the above-mentioned delayed initiation treatment schedule, and similar protection was seen, although lung virus titers were not reduced in the day-5 assay. Peptide 6 was well tolerated at doses up to 60 mg/kg/day. This zinc finger peptide may provide a new class of antivirals effective against influenza virus.

Specific DNA Recognition by a Synthetic, Monomeric Cys2His2 Zinc-Finger Peptide Conjugated to a Minor-Groove Binder

2007 ◽  
Vol 119 (36) ◽  
pp. 7010-7014 ◽  
Author(s):  
Olalla Vázquez ◽  
M. Eugenio Vázquez ◽  
Juan B. Blanco ◽  
Luis Castedo ◽  
José L. Mascareñas
Keyword(s):  
Zinc Finger ◽  
Dna Recognition ◽  
Minor Groove ◽  
Minor Groove Binder ◽  
A Minor ◽  
Zinc Finger Peptide

scholarly journals Modulation of DNA Binding of a Tramtrack Zinc Finger Peptide by the Metallothionein-Thionein Conjugate Pair

1998 ◽  
Vol 273 (28) ◽  
pp. 17425-17432 ◽  
Author(s):  
Guritno Roesijadi ◽  
Ralf Bogumil ◽  
Milan Vasák ◽  
Jeremias H. R. Kägi
Keyword(s):  
Dna Binding ◽  
Zinc Finger ◽  
Conjugate Pair ◽  
Zinc Finger Peptide

scholarly journals Characteristics of the Interaction of a Synthetic Human Tristetraprolin Tandem Zinc Finger Peptide with AU-rich Element-containing RNA Substrates

2003 ◽  
Vol 278 (22) ◽  
pp. 19947-19955 ◽  
Author(s):  
Perry J. Blackshear ◽  
Wi S. Lai ◽  
Elizabeth A. Kennington ◽  
Gary Brewer ◽  
Gerald M. Wilson ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Peptide ◽  
Tandem Zinc Finger

Metal binding to a zinc-finger peptide: a comparison between solution and the gas phase

2011 ◽  
Vol 47 (1) ◽  
pp. 412-414 ◽  
Author(s):  
Yana Berezovskaya ◽  
Craig T. Armstrong ◽  
Aimee L. Boyle ◽  
Massimiliano Porrini ◽  
Derek N. Woolfson ◽  
...  
Keyword(s):  
Gas Phase ◽  
Zinc Finger ◽  
Metal Binding ◽  
Zinc Finger Peptide

scholarly journals Characterization of the Zn(II) Binding Properties of the Human Wilms’ Tumor Suppressor Protein C-terminal Zinc Finger Peptide

2014 ◽  
Vol 53 (12) ◽  
pp. 6309-6320 ◽  
Author(s):  
Ka Lam Chan ◽  
Inna Bakman ◽  
Amy R. Marts ◽  
Yuksel Batir ◽  
Terry L. Dowd ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Zinc Finger ◽  
Protein C ◽  
Wilms Tumor ◽  
Tumor Suppressor Protein ◽  
Binding Properties ◽  
Zinc Finger Peptide

Zinc finger peptide cleavage by a dinuclear platinum compound

2013 ◽  
Vol 49 (62) ◽  
pp. 6986 ◽  
Author(s):  
John B. Mangrum ◽  
Ibrahim Zgani ◽  
Samantha D. Tsotsoros ◽  
Yun Qu ◽  
Nicholas P. Farrell
Keyword(s):  
Zinc Finger ◽  
Platinum Compound ◽  
Peptide Cleavage ◽  
Dinuclear Platinum ◽  
Zinc Finger Peptide
Sign in / Sign up

Export Citation Format

Share Document