Synthesis and antibacterial activity evaluation of C-5 side chain modified analogues of FYL-66, a potential agent against methicillin-resistant Staphylococcus aureus

MedChemComm ◽  
2015 ◽  
Vol 6 (6) ◽  
pp. 1156-1172 ◽  
Author(s):  
Xiaoyan Yang ◽  
Zicheng Li ◽  
Zhenling Wang ◽  
Zitai Sang ◽  
Haiyue Long ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Animal Models ◽  
Antibacterial Agent ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Biological Activities ◽  
Side Chain ◽  
Methicillin Resistant ◽  
Activity Evaluation

Monofluoro- (39), difluoro- (40) and trifluoro- (41) substituted analogues showed different biological activities, and 40 is a potent antibacterial agent in animal models.

scholarly journals Correction: Synthesis and antibacterial activity evaluation of C-5 side chain modified analogues of FYL-66, a potential agent against methicillin-resistant Staphylococcus aureus

MedChemComm ◽  
2015 ◽  
Vol 6 (9) ◽  
pp. 1700-1700
Author(s):  
Xiaoyan Yang ◽  
Zicheng Li ◽  
Zhenling Wang ◽  
Zitai Sang ◽  
Haiyue Long ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Side Chain ◽  
Methicillin Resistant ◽  
Activity Evaluation

Correction for ‘Synthesis and antibacterial activity evaluation of C-5 side chain modified analogues of FYL-66, a potential agent against methicillin-resistant Staphylococcus aureus’ by Xiaoyan Yang et al., MedChemComm, 2015, 6, 1156–1172.

scholarly journals Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) of Ethanol Extract of God's Crown (Phaleria macrocarpa) Leaves, Peel, and Fruit Flesh

2020 ◽  
Vol 31 (2) ◽  
pp. 81
Author(s):  
Rani Afifah Nur Hestiyani ◽  
Tri Okmawati Handini
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Antibacterial Agent ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Methicillin Resistant ◽  
Fruit Flesh ◽  
Phaleria Macrocarpa ◽  
Antibiotic Control

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that becomes the main concern since it is a multidrug-resistant organism and causes high morbidity and mortality. This study aimed to investigate the antibacterial activity of ethanolic extract of Phaleria macrocarpa leaves, peel, and fruit flesh on MRSA. This study was an experimental laboratory study with a post-test only control group design to assess the antibacterial activity of ethanolic extract from leaves, peel, and fruit flesh of Phaleria macrocarpa against MRSA ATCC 43300 and MRSA clinical isolates using a disk diffusion method. Extracts from the leaves, peel, and flesh of Phaleria macrocarpa had potential as an antibacterial agent against MRSA ATCC 43300 at a concentration of 40%, although not yet equivalent to antibiotic control. The ethanol extract of Phaleria macrocarpa peel at a concentration of 30-40% had potential as an antibacterial agent against MRSA clinical isolates, although not yet equivalent to antibiotic control. Further research needs to be performed so that Phaleria macrocarpa extract can be a potential source of subsequent antibacterial development against MRSA.

scholarly journals Investigation of the Anti-Methicillin-Resistant Staphylococcus aureus Activity of (+)-Tanikolide- and (+)-Malyngolide-Based Analogues Prepared by Asymmetric Synthesis

2021 ◽  
Vol 22 (12) ◽  
pp. 6400
Author(s):  
Joseph Breheny ◽  
Cian Kingston ◽  
Robert Doran ◽  
Joao Anes ◽  
Marta Martins ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Asymmetric Synthesis ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Antimicrobial Properties ◽  
Side Chain ◽  
Alkyl Side Chain ◽  
Methicillin Resistant ◽  
Antibacterial And Antifungal

Herein, we report antibacterial and antifungal evaluation of a series of previously prepared (+)-tanikolide analogues. One analogue, (4S,6S)-4-methyltanikolide, displayed promising anti-methicillin-resistant Staphylococcus aureus activity with a MIC of 12.5 µg/mL. Based on the antimicrobial properties of the structurally related (−)-malyngolide, two further analogues (4S,6S)-4-methylmalyngolide and (4R,6S)-4-methylmalyngolide bearing a shortened n-nonyl alkyl side chain were prepared in the present study using a ZrCl4-catalysed deprotection/cyclisation as the key step in their asymmetric synthesis. When these were tested for activity against anti-methicillin-resistant Staphylococcus aureus, the MIC increased to 50 µg/mL.

Antibacterial Activity of Ecklonia cava Against Methicillin-Resistant Staphylococcus aureus and Salmonella spp.

2010 ◽  
Vol 7 (4) ◽  
pp. 435-441 ◽  
Author(s):  
Jang-Gi Choi ◽  
Ok-Hwa Kang ◽  
Obiang-Obounou Brice ◽  
Young-Seob Lee ◽  
Hee-Sung Chae ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Ecklonia Cava ◽  
Salmonella Spp ◽  
Methicillin Resistant

Antibacterial activity of aminoderivatized chitosans against methicillin-resistant Staphylococcus aureus (MRSA)

2009 ◽  
Vol 17 (20) ◽  
pp. 7108-7112 ◽  
Author(s):  
Dae-Sung Lee ◽  
Seong-Yun Jeong ◽  
Young-Mog Kim ◽  
Myung-Suk Lee ◽  
Chang-Bum Ahn ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant
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