A structure–activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor

MedChemComm ◽  
2015 ◽  
Vol 6 (11) ◽  
pp. 1998-2003 ◽  
Author(s):  
Monika Szabo ◽  
Tracey Huynh ◽  
Celine Valant ◽  
J. Robert Lane ◽  
Patrick M. Sexton ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Muscarinic Acetylcholine Receptor ◽  
Allosteric Modulator ◽  
Allosteric Modulators ◽  
Positive Allosteric Modulator ◽  
Muscarinic Acetylcholine ◽  
Structure Activity ◽  
Relationship Study ◽  
Orthosteric Ligands ◽  
Unique Potential

Positive allosteric modulators targeting the M4 muscarinic acetylcholine receptor offer greater sub-type selectivity and unique potential as CNS agents through their novel mode of action to traditional orthosteric ligands.

scholarly journals Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

2014 ◽  
Vol 39 (7) ◽  
pp. 1578-1593 ◽  
Author(s):  
Nellie E Byun ◽  
Michael Grannan ◽  
Michael Bubser ◽  
Robert L Barry ◽  
Analisa Thompson ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Antipsychotic Drug ◽  
Muscarinic Acetylcholine Receptor ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Muscarinic Acetylcholine

scholarly journals Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284

2016 ◽  
Vol 90 (3) ◽  
pp. 177-187 ◽  
Author(s):  
Deborah L. Smith ◽  
Jennifer E. Davoren ◽  
Jeremy R. Edgerton ◽  
John T. Lazzaro ◽  
Che-Wah Lee ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Muscarinic Acetylcholine Receptor ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Muscarinic Acetylcholine ◽  
M1 Muscarinic Acetylcholine Receptor ◽  
M1 Muscarinic
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