scholarly journals Design of magnetic molecularly imprinted polymer nanoparticles for controlled release of doxorubicin under an alternative magnetic field in athermal conditions

Nanoscale ◽  
2015 ◽  
Vol 7 (45) ◽  
pp. 18891-18896 ◽  
Author(s):  
N. Griffete ◽  
J. Fresnais ◽  
A. Espinosa ◽  
C. Wilhelm ◽  
A. Bée ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Controlled Release ◽  
Cancer Therapy ◽  
Drug Release ◽  
Molecularly Imprinted Polymer ◽  
Polymer Nanoparticles ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Magnetic Molecularly Imprinted Polymer ◽  
Alternative Magnetic Field

An innovative magnetic delivery nanomaterial for triggered cancer therapy showing active control over drug release by using an alternative magnetic field is proposed.

scholarly journals Protein Denaturation through the Use of Magnetic Molecularly Imprinted Polymer Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3980
Author(s):  
Charlotte Boitard ◽  
Aude Michel ◽  
Christine Ménager ◽  
Nébéwia Griffete
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Protein Function ◽  
Fluorescent Protein ◽  
Protein Denaturation ◽  
Polymer Nanoparticles ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Magnetic Molecularly Imprinted Polymer ◽  
Alternative Magnetic Field ◽  
Green Fluorescent

The inhibition of the protein function for therapeutic applications remains challenging despite progress these past years. While the targeting application of molecularly imprinted polymer are in their infancy, no use was ever made of their magnetic hyperthermia properties to damage proteins when they are coupled to magnetic nanoparticles. Therefore, we have developed a facile and effective method to synthesize magnetic molecularly imprinted polymer nanoparticles using the green fluorescent protein (GFP) as the template, a bulk imprinting of proteins combined with a grafting approach onto maghemite nanoparticles. The hybrid material exhibits very high adsorption capacities and very strong affinity constants towards GFP. We show that the heat generated locally upon alternative magnetic field is responsible of the decrease of fluorescence intensity.

Molecularly imprinted polymer nanoparticles for olanzapine recognition: application for solid phase extraction and sustained release

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 9154-9166 ◽  
Author(s):  
Sina Farzaneh ◽  
Ebadullah Asadi ◽  
Majid Abdouss ◽  
Azam Barghi-Lish ◽  
Saman Azodi-Deilami ◽  
...  
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Polymer Nanoparticles ◽  
Therapeutic Drug ◽  
Phase Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

The aim of this study was to prepare efficient imprinted polymer nanoparticles from an olanzapine template for the controlled release of olanzapine as a therapeutic drug for CNS diseases.

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