DNA/protein interaction, cytotoxic activity and magnetic properties of amino-alcohol Schiff base derived Cu(ii)/Ni(ii) metal complexes: influence of the nuclearity and metal ions

RSC Advances ◽  
2015 ◽  
Vol 5 (47) ◽  
pp. 37085-37095 ◽  
Author(s):  
Meiju Niu ◽  
Zhen Li ◽  
Huanhuan Li ◽  
Xiao Li ◽  
Jianmin Dou ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Schiff Base ◽  
Metal Ions ◽  
Metal Complexes ◽  
Cytotoxic Activity ◽  
Protein Interaction ◽  
Amino Alcohol ◽  
Polynuclear Complexes ◽  
Schiff Base Ligands ◽  
Dna Protein Interaction

The reactions of amino-alcohol derived Schiff-base ligands with Cu(ii) and Ni(ii) salts have afforded four novel polynuclear complexes, which exhibited interesting magnetic and cytotoxic properties.

DNA/protein interaction and cytotoxic activity of imidazole terpyridine derived Cu(ii)/Zn(ii) metal complexes

2014 ◽  
Vol 43 (34) ◽  
pp. 13018 ◽  
Author(s):  
V. M. Manikandamathavan ◽  
T. Weyhermüller ◽  
R. P. Parameswari ◽  
M. Sathishkumar ◽  
V. Subramanian ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Cytotoxic Activity ◽  
Protein Interaction ◽  
Dna Protein Interaction

Synthesis, Characterization, and Antibacterial and Cytotoxic Study of Metal Complexes with Schiff Base Ligands

2008 ◽  
Vol 61 (4) ◽  
pp. 288 ◽  
Author(s):  
Lei Shi ◽  
Rui-Qin Fang ◽  
Jia-Yu Xue ◽  
Zhu-Ping Xiao ◽  
Shu-Hua Tan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Primary Amines ◽  
Tumour Cell Line ◽  
Cytotoxic Activities ◽  
Ionization Mass ◽  
Schiff Base Ligands

The synthesis of 16 metal complexes from four Schiff bases prepared from 5-chloro-2-hydroxybenzaldehyde and primary amines has been described. The synthesized Schiff base ligands and their complexes were characterized by elemental analyses, spectroscopic (UV, IR, 1H and 13C NMR, electrospray ionization-mass spectrometry) methods, and magnetic and conductance measurements. Furthermore, complexes 1a, 1b, 3d, 4a, and 4d were characterized by X-ray diffraction analysis. After the structural characterization, all the compounds were tested in vitro for their antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, and Staphylococcus aureus) activities. The cytotoxic activities of the synthesized compounds were evaluated in vitro against human chronic myeloid leukaemia cells (K562) and a human nasopharyngeal epidermoid tumour cell line. The results indicated that most of the complexes showed good cytotoxic activity against human cancer cell lines but weak cytotoxic activity against a human normal cell line (L02). Among the compounds tested, the cobalt complexes 1a, 2a, 3a, and 4a showed the most favourable antibacterial and cytotoxic activities.

scholarly journals Ni(II) Complexes with Schiff Base Ligands: Preparation, Characterization, DNA/Protein Interaction and Cytotoxicity Studies

Molecules ◽  
2017 ◽  
Vol 22 (10) ◽  
pp. 1772 ◽  
Author(s):  
Hui Yu ◽  
Wei Zhang ◽  
Qing Yu ◽  
Fu-Ping Huang ◽  
He-Dong Bian ◽  
...  
Keyword(s):  
Schiff Base ◽  
Protein Interaction ◽  
Schiff Base Ligands ◽  
Cytotoxicity Studies ◽  
Dna Protein Interaction

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

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