Deep eutectic solvent: a simple, environmentally benign reaction media for regioselective synthesis of 2,3,4-trisubstituted 1H-pyrroles

RSC Advances ◽  
2015 ◽  
Vol 5 (44) ◽  
pp. 35166-35174 ◽  
Author(s):  
Hanuman P. Kalmode ◽  
Kamlesh S. Vadagaonkar ◽  
Kaliyappan Murugan ◽  
Sattey Prakash ◽  
Atul C. Chaskar
Keyword(s):  
Deep Eutectic Solvent ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Highly Efficient ◽  
Reaction Media

A greener, rapid and highly efficient synthetic protocol for the construction of pyrroles has been achieved.

ChemInform Abstract: Deep Eutectic Solvent: A Simple, Environmentally Benign Reaction Media for Regioselective Synthesis of 2,3,4-Trisubstituted 1H-Pyrroles.

ChemInform ◽  
2015 ◽  
Vol 46 (35) ◽  
pp. no-no
Author(s):  
Hanuman P. Kalmode ◽  
Kamlesh S. Vadagaonkar ◽  
Kaliyappan Murugan ◽  
Sattey Prakash ◽  
Atul C. Chaskar
Keyword(s):  
Deep Eutectic Solvent ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Reaction Media

Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives

2020 ◽  
Vol 16 (8) ◽  
pp. 1185-1190 ◽  
Author(s):  
Fatemeh Malamiri ◽  
Samad Khaksar ◽  
Rashid Badri ◽  
Elham Tahanpesar
Keyword(s):  
Deep Eutectic Solvent ◽  
Efficient Synthesis ◽  
Melting Points ◽  
Reaction Conditions ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Reaction Media

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media. Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points. Results: Various products were obtained in good to excellent yields under reaction conditions. Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.

ChemInform Abstract: Deep Eutectic Solvent as a Highly Efficient Reaction Media for the One-Pot Synthesis of Benzo-Fused Seven-Membered Heterocycles.

ChemInform ◽  
2016 ◽  
Vol 47 (48) ◽  
Author(s):  
Ahmad Shaabani ◽  
Seyyed Emad Hooshmand ◽  
Mohammad Taghi Nazeri ◽  
Ronak Afshari ◽  
Shima Ghasemi
Keyword(s):  
Deep Eutectic Solvent ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
The One ◽  
Reaction Media

scholarly journals Deep eutectic solvent as a highly efficient reaction media for the one-pot synthesis of benzo-fused seven-membered heterocycles

2016 ◽  
Vol 57 (33) ◽  
pp. 3727-3730 ◽  
Author(s):  
Ahmad Shaabani ◽  
Seyyed Emad Hooshmand ◽  
Mohammad Taghi Nazeri ◽  
Ronak Afshari ◽  
Shima Ghasemi
Keyword(s):  
Deep Eutectic Solvent ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
The One ◽  
Reaction Media

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

Application of Deep Eutectic Solvent (DES) as a Reaction Media for the Esterification of Acrylic Acid with n-Butanol

2015 ◽  
Vol 13 (3) ◽  
pp. 389-393 ◽  
Author(s):  
Emine Sert
Keyword(s):  
Catalytic Activity ◽  
Acrylic Acid ◽  
Batch Reactor ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Molar Ratio ◽  
Catalyst Loading ◽  
Toluene Sulfonic Acid ◽  
Effects Of Temperature ◽  
Reaction Media

Abstract Within the framework of green chemistry, catalysts should be met different criteria such as biodegradability, recyclability, flammability, non-toxicity and low price. Acidic deep eutectic solvent (DES) have been synthesized for this purpose, by mixing para-toluene sulfonic acid and choline chloride. The catalytic activity of DES was studied in the esterification of acrylic acid with n-butanol. The usage of DES as catalyst is simple, safe and cheap. The effects of temperature, catalyst loading, n-butanol/acrylic acid molar ratio on the conversion of acrylic acid were performed. The batch reactor experiments were carried out at temperatures of 338, 348, 358 and 368 K, molar ratio of butanol to acrylic acid of 1, 2,3 and catalyst loading of 10, 15, 20 and 90 g/L. 90.2% of acrylic acid conversion was achieved at a temperature of 358 K and catalyst loading of 20 g/L. Reusability of DES was investigated. Reusability and catalytic activity makes DES efficient as catalyst.

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