Mixed-ligand copper(ii) Schiff base complexes: the role of the co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity

2016 ◽  
Vol 45 (22) ◽  
pp. 9073-9087 ◽  
Author(s):  
Wen-Jing Lian ◽  
Xin-Tian Wang ◽  
Cheng-Zhi Xie ◽  
He Tian ◽  
Xue-Qing Song ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Protein Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Schiff Base Complexes ◽  
Biological Features

Four novel mixed-ligand copper(ii) Schiff base complexes were synthesized and characterized. The biological features of the complexes and how acetic auxiliary ligands manipulate these features were investigated.

Mixed ligand copper(ii) dicarboxylate complexes: the role of co-ligand hydrophobicity in DNA binding, double-strand DNA cleavage, protein binding and cytotoxicity

2015 ◽  
Vol 44 (22) ◽  
pp. 10210-10227 ◽  
Author(s):  
Rangasamy Loganathan ◽  
Sethu Ramakrishnan ◽  
Mani Ganeshpandian ◽  
Nattamai S. P. Bhuvanesh ◽  
Mallayan Palaniandavar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Protein Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Double Strand Dna

Mixed ligand 5,6-dmp and 3,4,7,8-tmp complexes display more prominent cytotoxicity and higher apoptotic inducing ability.

Mixed-ligand Cu(II)–vanillin Schiff base complexes; effect of coligands on their DNA binding, DNA cleavage, SOD mimetic and anticancer activity

2013 ◽  
Vol 60 ◽  
pp. 216-232 ◽  
Author(s):  
Sartaj Tabassum ◽  
Samira Amir ◽  
Farukh Arjmand ◽  
Claudio Pettinari ◽  
Fabio Marchetti ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Anticancer Activity ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Schiff Base Complexes

Mixed-ligand copper(ii) Schiff base complexes: the vital role of co-ligands in DNA/protein interactions and cytotoxicity

2017 ◽  
Vol 41 (3) ◽  
pp. 1267-1283 ◽  
Author(s):  
Sellamuthu Kathiresan ◽  
Subramanian Mugesh ◽  
Jamespandi Annaraj ◽  
Maruthamuthu Murugan
Keyword(s):  
Cell Death ◽  
Cell Wall ◽  
Schiff Base ◽  
Protein Interactions ◽  
Apoptotic Cell ◽  
Vital Role ◽  
Mixed Ligand ◽  
Schiff Base Complexes ◽  
Antibacterial Mechanism

Four new mixed-ligand copper(ii) complexes display an antibacterial mechanism of cell death via cell-wall rupture and cytotoxicity via apoptotic cell death.

Syntheses of Zn(II) and Cu(II) Schiff base complexes using N,O donor Schiff base ligand: Crystal structure, DNA binding, DNA cleavage, docking and DFT study

Polyhedron ◽  
2018 ◽  
Vol 141 ◽  
pp. 153-163 ◽  
Author(s):  
Pravat Ghorai ◽  
Rumpa Saha ◽  
Sutanwi Bhuiya ◽  
Suman Das ◽  
Paula Brandão ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Schiff Base Complexes ◽  
Dft Study

Mixed ligand copper(II) complexes of 1,10-phenanthroline with tridentate phenolate/pyridyl/(benz)imidazolyl Schiff base ligands: Covalent vs non-covalent DNA binding, DNA cleavage and cytotoxicity

2014 ◽  
Vol 140 ◽  
pp. 255-268 ◽  
Author(s):  
Chandrasekaran Rajarajeswari ◽  
Mani Ganeshpandian ◽  
Mallayan Palaniandavar ◽  
Anvarbatcha Riyasdeen ◽  
Mohammad Abdulkadher Akbarsha
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Schiff Base Ligands

Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base

2010 ◽  
Vol 64 (3) ◽  
Author(s):  
Natarajan Raman ◽  
Ramaraj Jeyamurugan ◽  
Mariyyappan Subbulakshmi ◽  
Raja Boominathan ◽  
Chithu Yuvarajan
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Dna Cleavage ◽  
Double Helix ◽  
Structural Features ◽  
Schiff Base Complexes ◽  
Diffusion Method ◽  
Spectral Techniques ◽  
Antimicrobial Studies

AbstractA novel series of Co(II), Ni(II), Cu(II), Zn(II), and VO(IV) complexes has been synthesized from the Schiff base derived from 4-[(3,4-dimethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one and 1,2-diaminobenzene. Structural features were determined by analytical and spectral techniques. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods and viscosity measurements. Experimental results indicate that the complexes are able to form adducts with DNA and to distort the double helix by changing the base stacking. Lower DNA affinity of the VO(IV) complex is caused by the change of coordination geometry by the vanadyl ion resulting in a somewhat unfavorable configuration for the DNA binding. Oxidative DNA cleavage activities of the complexes were studied with supercoiled (SC) pUC19 DNA using gel electrophoresis; the mechanism studies revealed that the hydroxyl radical is likely to be the reactive species responsible for the cleavage of pUC19 DNA by the synthesized complexes. The in vitro antimicrobial screening effects of the investigated compounds were monitored by the disc diffusion method. The synthesized Schiff base complexes exhibit higher antimicrobial activity than the respective free Schiff base.

Syntheses, characterizations, crystal structures, and biological activities of two new mixed ligand Ni(II) and Cu(II) Schiff base complexes

2015 ◽  
Vol 68 (4) ◽  
pp. 632-649 ◽  
Author(s):  
S. Yousef Ebrahimipour ◽  
Maryam Mohamadi ◽  
Jesús Castro ◽  
Nasrin Mollania ◽  
Hadi Amiri Rudbari ◽  
...  
Keyword(s):  
Schiff Base ◽  
Crystal Structures ◽  
Biological Activities ◽  
Mixed Ligand ◽  
Schiff Base Complexes
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