Synthesis, characterization and biological evaluation of labile intercalative ruthenium(ii) complexes for anticancer drug screening

2016 ◽  
Vol 45 (33) ◽  
pp. 13135-13145 ◽  
Author(s):  
Huaiyi Huang ◽  
Pingyu Zhang ◽  
Yu Chen ◽  
Kangqiang Qiu ◽  
Chengzhi Jin ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Cellular Uptake ◽  
Drug Screening ◽  
Biological Evaluation ◽  
Dual Mode ◽  
Dna Binding Affinity ◽  
Dna Binding Complexes ◽  
Cellular Uptake Efficiency

[Ru(tpy)(N^N)Cl]+ were synthesized for anticancer evolution. Ru2–Ru4 were dual-mode DNA-binding complexes and exhibited higher DNA binding affinity, better cellular uptake efficiency and higher anticancer activity than Ru1.

Synthesis, spectroscopic investigation, and DFT study of N,N′-disubstituted ferrocene-based thiourea complexes as potent anticancer agents

2018 ◽  
Vol 47 (6) ◽  
pp. 1868-1878 ◽  
Author(s):  
Faiza Asghar ◽  
Saira Fatima ◽  
Sadaf Rana ◽  
Amin Badshah ◽  
Ian S. Butler ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Anticancer Agents ◽  
Spectroscopic Investigation ◽  
Dft Study ◽  
Redox Potentials ◽  
Dna Binding Affinity ◽  
Dna Binders ◽  
Homo Lumo

The DNA binding affinity of ferrocenyl thioureas (A1–A9) explored by CV and UV ascertain them as noble DNA binders. The complexes also publicized decent antioxidant and anticancer activity. DFT-based HOMO/LUMO energies are comparable with experimentally calculated redox potentials.

Synthesis, DNA binding affinity and anticancer activity of novel 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines

2016 ◽  
Vol 14 (39) ◽  
pp. 9294-9305 ◽  
Author(s):  
K. N. Visweswara Sastry ◽  
Sunitha Rani Routhu ◽  
Soma Gupta Datta ◽  
Narayana Nagesh ◽  
Bathini Nagendra Babu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Cancer Therapeutics ◽  
New Class ◽  
Dna Binding Affinity

Cancer therapeutics: a new class of anticancer heterocycles was synthesized.

scholarly journals DSE ‐ FRET : A new anticancer drug screening assay for DNA binding proteins

2014 ◽  
Vol 105 (7) ◽  
pp. 870-874 ◽  
Author(s):  
Toru Miyagi ◽  
Bunsyo Shiotani ◽  
Ryuya Miyoshi ◽  
Takuya Yamamoto ◽  
Takanori Oka ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Drug ◽  
Drug Screening ◽  
Binding Proteins ◽  
Dna Binding Proteins ◽  
Screening Assay ◽  
Drug Screening Assay

Solid-phase synthesis of new pyrrolobenzodiazepine–chalcone conjugates: DNA-binding affinity and anticancer activity

2008 ◽  
Vol 18 (7) ◽  
pp. 2434-2439 ◽  
Author(s):  
Ahmed Kamal ◽  
N. Shankaraiah ◽  
S. Prabhakar ◽  
Ch. Ratna Reddy ◽  
N. Markandeya ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Dna Binding Affinity

DNA-binding affinity and anticancer activity of β-carboline–chalcone conjugates as potential DNA intercalators: Molecular modelling and synthesis

2015 ◽  
Vol 59 ◽  
pp. 130-139 ◽  
Author(s):  
Nagula Shankaraiah ◽  
K.P. Siraj ◽  
Shalini Nekkanti ◽  
Vunnam Srinivasulu ◽  
Pankaj Sharma ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Molecular Modelling ◽  
Dna Intercalators ◽  
Dna Binding Affinity

Mononuclear Tetraamineplatinum(II) Complexes: Synthesis, Anticancer Activity, DNA Binding, and Cellular Uptake

2001 ◽  
Vol 84 (10) ◽  
pp. 3023-3030 ◽  
Author(s):  
Marc S. Robillard ◽  
Bart A. J. Jansen ◽  
Martin Lochner ◽  
Hervé Geneste ◽  
Yi Li ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Cellular Uptake
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