Ionic complex of a rhodamine dye with aggregation-induced emission properties

2017 ◽  
Vol 196 ◽  
pp. 177-190 ◽  
Author(s):  
Pei-Yi Huang ◽  
Jhen-Yan Gao ◽  
Cheng-Yu Song ◽  
Jin-Long Hong
Keyword(s):  
Blood Protein ◽  
Complexation Reaction ◽  
Ionic Complex ◽  
Luminescent Sensor ◽  
Analogous Complex ◽  
Ionic Bonds ◽  
Organic Amines ◽  
Rhodamine Dye ◽  
External Stimuli ◽  
Protein Bovine Serum Albumin

An AIE-active rhodamine based luminogen was prepared via a complexation reaction between non-emissive rhodamine hydrazide (RdH) and bulky camphorsulfonic acid (CSA). Besides acting to open the spirolactam ring of RdH, CSA also imposes a rotational restriction on the resultant ionic complex, RdH(CSA)x. Without CSA, the analogous complex RdH(HCl)3 is a luminogen with aggregation-caused quenching (ACQ) properties. The ionic bonds of RdH(CSA)3 are sensitive to several external stimuli and therefore it is a luminescent sensor for metal ions, organic amines and the blood protein bovine serum albumin (BSA). Besides being a sensor for BSA, the ionic RdH(CSA)3 is also a denaturant capable of uncoiling the peptide chain of BSA.

scholarly journals DETERMINING TARTRATE IONS IN THE SAMPLES OF MINERAL TABLE WATERS BY THE DECAY OF MOLECULAR LUMINESCENCE OF RUTIN IN COMPLEX WITH YTTRIUM (III)

2018 ◽  
Vol 12 (2) ◽  
Author(s):  
E. Malinka ◽  
S. Beltyukova ◽  
V. Boychenko
Keyword(s):  
Luminescent Properties ◽  
Luminescence Decay ◽  
Rapid Screening ◽  
Calibration Plot ◽  
Complexation Reaction ◽  
Linear Calibration ◽  
Potassium Tartrate ◽  
Luminescent Sensor ◽  
Molecular Luminescence ◽  
Short Time

The yttrium (III)-rutin (Rut) complex in the presence of bovine serum albumin (BSA) is suggested as a luminescent sensor to determine tartrate ions (Tart). It has been experimentally established that tartrate ions reduce the luminescence intensity (Ilum) of the Y(III)-Rut complex in the presence of BSA and Tart. The spectral and luminescent properties of the Y(III)-Rut complex in the presence of BSA have been studied. The peak of the luminescence spectrum of the Y(III)-Rut complex in the presence of BSA is at λ=570 nm. In the presence of potassium tartrate, Ilum of the Y(III)-Rut complex decreases, and the maximum luminescence shifts to the longwave region of the spectrum (λ=590 nm). It is known that the luminescence decay can be caused by various processes, including reactions in the excited state, energy transfer, formation of complexes, and collisional decay. It can be assumed that the decay effect of the Y(III)-Rut complex is due to the complexation reaction of Y(III) with Tart, that leads to the destruction of the Y(III)-Rut complex. The luminescence decay of the Y(III)-Rut complex in the presence of BSA by means of Tart follows the Stern-Volmer relationship. The Stern-Volmer constant K is 1230 l/mol. The method of luminescent determination of tartrate ions in mineral table waters has been developed. It is based on using the decay of rutin’s molecular luminescence in the Y(III)-rutin complex in the presence of BSA. The linear calibration plot for tartrate ions has been obtained over the range of Tart concentrations of 0.02 to 0.20 mg/ml. The limit of determining potassium tartrate is 0.01 mg/ml. The technique has an advantage over the existing ones due to the absence of toxic reagents, and short-time analysis. Besides, it allows rapid screening of samples of mineral table water.

On the Natural Blood Coagulation Inhibitor System Investigations of Inhibitor Factors Based on Antithrombin Deficient Blood

1965 ◽  
Vol 14 (03/04) ◽  
pp. 473-489 ◽  
Author(s):  
O Egeberg
Keyword(s):  
Normal Level ◽  
Antithrombin Iii ◽  
Strong Support ◽  
Blood Protein ◽  
Coagulation Inhibitor ◽  
Inhibitor System ◽  
Normal Human ◽  
Partial Deficiency ◽  
Antithrombin Iii Activity ◽  
Prothrombinase Activity

SummaryNatural coagulation inhibitor factors were studied in sera, or in fractions of sera, from patients with congenital partial deficiency of antithrombin and from normal persons. In the patients’ sera the progressive antithrombin (antithrombin III) and heparin cofactor (antithrombin II) had both been measured around 50 per cent of normal level.No decreased activity could be demonstrated in the patients’ sera as to antiprothrombinase, the inhibitor against blood intrinsic prothrombinase activity.For anticonvertin, the inhibitor against the tissue convertin complex, the activity was found decreased to about the same level as that demonstrated for antithrombin III and II. The results lend strong support to the hypothesis that the activities measured as anticonvertin, antithrombin III and antithrombin II represent functions of the same blood protein, which on the other side appears to be distinct from antiprothrombinase. In accordance with this explanation, an antithrombin III concentrate had also antithrombin II and anticonvertin activity, and further, adsorption of a normal human serum with convertin appeared to specifically reduce its antithrombin III activity.The inhibitor against activated antihemophilic C factor (AHC’ = activated f. XI) was studied in sera adsorbed with BaS04 and celite. The inhibitor activity was found at normal level in the patients’ sera, consistent with the view that anti-AHC’ is distinct from antithrombin III, II and from anticonvertin. No acceleration of the anti-AHC’ activity could be demonstrated after addition to the inhibition mixture of weak solutions of heparin.The results are discussed.

417. Practical Diffusive Monitor for Sampling Organic Amines

1999 ◽  
Author(s):  
C. Manning ◽  
M. Parker ◽  
T. Yeung
Keyword(s):  
Organic Amines

Catastrophe Theory in Explaining Price Dynamics on the Real Estate Market

2013 ◽  
Vol 21 (3) ◽  
pp. 51-61 ◽  
Author(s):  
Mirosław Belej
Keyword(s):  
Real Estate ◽  
Catastrophe Theory ◽  
Open Systems ◽  
Real Estate Market ◽  
Sensitivity Threshold ◽  
State Variables ◽  
The Real ◽  
The Real Estate ◽  
The Real Estate Market ◽  
External Stimuli

Abstract The real estate market is an open system, which implies that it is able to exchange signals with other open systems and dynamic systems. The evolution of a market system over time can be described mathematically. If the system's sensitivity threshold to external stimuli is exceeded, it becomes destabilized and moves from a near-balanced state to a state that is far from equilibrium. Those dynamic processes often induce key changes in the system's trajectory of evolution. In search of equilibrium, the system becomes transformed in a process of discontinuous and discrete changes in state variables. The above statement constitutes the research hypothesis in this article. In this study, an attempt was made to develop a mathematical model for visualizing the evolutionary path of the real estate market in the form of continuous changes interrupted by discontinuous changes. The qualitative transformation of the system will be evaluated with the use of the catastrophe theory.

Smart Polymers and their Applications: A Review

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Gore S. A. ◽  
Gholve S. B. ◽  
Savalsure S. M. ◽  
Ghodake K. B. ◽  
Bhusnure O. G. ◽  
...  
Keyword(s):  
Oil Recovery ◽  
Water Soluble ◽  
Solution Temperature ◽  
Smart Polymers ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Water Soluble Polymers ◽  
Commercial Applications ◽  
Stimuli Sensitive ◽  
External Stimuli

Smart polymers are materials that respond to small external stimuli. These are also referred as stimuli responsive materials or intelligent materials. Smart polymers that can exhibit stimuli-sensitive properties are becoming important in many commercial applications. These polymers can change shape, strength and pore size based on external factors such as temperature, pH and stress. The stimuli include salt, UV irradiation, temperature, pH, magnetic or electric field, ionic factors etc. Smart polymers are very promising applicants in drug delivery, tissue engineering, cell culture, gene carriers, textile engineering, oil recovery, radioactive wastage and protein purification. The study is focused on the entire features of smart polymers and their most recent and relevant applications. Water soluble polymers with tunable lower critical solution temperature (LCST) are of increasing interest for biological applications such as cell patterning, smart drug release, DNA sequencing etc.

Intracellular trafficking and cytoplasmic streaming under abiotic stress conditions

2019 ◽  
Vol 6 (04) ◽  
Author(s):  
JESHIMA KHAN YASIN ◽  
ANIL KUMAR SINGH
Keyword(s):  
Plasma Membrane ◽  
Abiotic Stress ◽  
Confocal Microscopy ◽  
Fusion Protein ◽  
Intracellular Trafficking ◽  
Cytoplasmic Streaming ◽  
Living Cells ◽  
Stress Conditions ◽  
Vesicle Formation ◽  
External Stimuli

Cytoplasmic streaming is one among the vital activities of the living cells. In plants cytolplasmic streaming could clearly be seen in hypocotyls of growing seedlings. To observe cytoplsmic streaming and its correlated intracellular trafficking an investigation was conducted in legumes in comparison with GFP-AtRab75 and 35S::GFP:δTIP tonoplast fusion protein expressing arabidopsis lines. These seedlings were observed under confocal microscopy with different buffer incubation treatments and under different stress conditions. GFP expressing 35S::GFP:δTIP tonoplast lines were looking similar to the control lines and differ under stress conditions. Movement of cytoplasmic invaginations within the tonoplast and cytoplasmic sub vesicle or bulb budding during cytoplasmic streaming was observed in hypocotyls of At-GFP tonoplast plants. We found the cytoplasmic bulbs/ vesicles or sub vesicle formation from the plasma membrane. The streaming speed also depends on the incubation medium in which the specimen was incubated, indicating that the external stimuli as well as internal stimuli can alter the speed of streaming

Abnormal neurodevelopment outcome in case of neonatal hyperekplexia secondary to missense mutation in GLRB gene

2020 ◽  
Vol 13 (12) ◽  
pp. e236152
Author(s):  
Naveen Parkash Gupta ◽  
Vinita Verma ◽  
Saurabh Chopra ◽  
Vivek Choudhury
Keyword(s):  
Genetic Testing ◽  
Missense Mutation ◽  
Genetic Predisposition ◽  
Seizure Disorder ◽  
Β Subunit ◽  
Tonic Spasm ◽  
Initial Improvement ◽  
External Stimuli ◽  
Neurodevelopment Outcome

Hyperekplexia is an exaggerated startle to external stimuli associated with a generalised increase in tone seen in neonates with both sporadic and genetic predisposition. This is an uncommon neurological entity that is misdiagnosed as seizure. A 28-days-old infant was admitted to us with characteristic intermittent generalised tonic spasm being treated as a seizure disorder. The infant had characteristic stiffening episode, exaggerated startle and non-habituation on tapping the nose. Hyperekplexia was suspected and confirmed by genetic testing (mutation in the β subunit of glycine was found). Initial improvement was seen with the use of clonazepam, which was not sustained. At the age of 4.5 years, the child is still having neurobehavioural issues like hyperactivity and sensory hyper-responsiveness. Usually, hyperekplexia is benign in nature. We report a case of hyperekplexia with non-sense mutation in the β subunit of GlyR gene having abnormal neurodevelopmental findings at 4.5 years.

Leading Professionals

2017 ◽  
Author(s):  
Laura Empson
Keyword(s):  
Mergers And Acquisitions ◽  
Distributed Leadership ◽  
Investment Banks ◽  
Professional Organizations ◽  
Power Dynamics ◽  
Consulting Firms ◽  
Complex Power ◽  
Plural Leadership ◽  
External Stimuli

This book analyses the complex power dynamics and interpersonal politics that lie at the heart of leadership in professional organizations, such as accounting, law, and consulting firms, investment banks, hospitals, and universities. It is based on scholarly research into many of the world’s leading professional organizations across a range of sectors, including interviews with over 500 senior professionals in sixteen countries. Drawing on the latest academic theory to analyse exactly how professionals in organizations come together to create ‘leadership’, it provides new insights into how leaders lead when there is no traditional hierarchy to support them, their own authority is contingent, and they must constantly renegotiate relationships with relatively autonomous professional peers. It explores how leaders persuade highly intelligent, educated, and opinionated professionals to work together; how change happens within professional organizations; and why leaders so often fail. Part I introduces the concept of plural leadership, analysing how leaders establish and maintain their positions within leadership constellations, and the implications for governance in the context of collective or distributed leadership. Part II examines the complex, challenging relationships between professionals as they seek to influence their organizations, including the phenomena of leadership dyads, insecure overachievers, social control, and the rise of the management professional. Part III examines the shifts in the locus of power as professional organizations grow, adapt, and react to external stimuli such as mergers and acquisitions and economic crises. The conclusion identifies the paradoxes inherent in professional organizations and examines the role of leaders in attempting to reconcile them.

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