Interactions of the innate immune system with carbon nanotubes

AbstractThe lectin pathway of the complement system is an integral component of the innate immune system recognizing pathogens through patterns of sugar moieties displayed on their surfaces and neutralizing them through an antibody-independent reaction cascade. Many engineered nanoparticles incite complement through the lectin pathway, but these nanoparticles inherently do not express surface-exposed sugars. However, the projected polymeric surface architecture of nanoparticles may transiently resemble structural motifs of peptidoglycan constituents of pathogens and trigger the lectin pathway. We discuss these issues in relation to nanomedicine design and immune safety.

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Das Komplementsystem

Hämostaseologie ◽

10.5482/ha-1191 ◽

2012 ◽

Vol 32 (04) ◽

pp. 276-285 ◽

Cited By ~ 3

Author(s):

V. Frauenknecht ◽

V. Schroeder

Keyword(s):

Coronary Artery Disease ◽

Complement System ◽

Innate Immune System ◽

Innate Immune ◽

The Other ◽

Atherosclerotic Plaques ◽

Inflammatory Processes ◽

Artery Disease ◽

The Complement System ◽

Novel Therapeutic

SummaryAtherosclerotic diseases such as coronary artery disease and ischaemic stroke are caused by chronic inflammation in arterial vessel walls. The complement system is part of the innate immune system. It is involved in many processes contributing to onset and development of atherosclerotic plaques up to the final stage of acute thrombotic events. This is due to its prominent role in inflammatory processes. In addition, there is increasing evidence that interactions between complement and coagulation provide a link between inflammation and thrombosis. On the other hand, the complement system also has an atheroprotective function through the clearance of apoptotic material.The knowledge of these complex mechanisms will become increasingly important, also for clinicians, since it may lead to novel therapeutic and diagnostic options. Therapies targeting the complement system have the potential to reduce tissue damage caused by acute ischaemic events. Whether early anti-inflammatory and anti-complement therapy may be able to prevent atherosclerosis, remains a hot topic for research.

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The complement system

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.050102 ◽

2010 ◽

pp. 213-224

Author(s):

Marina Botto ◽

Mark J. Walport

Keyword(s):

Immune System ◽

Complement System ◽

Immune Complexes ◽

Innate Immune System ◽

Inflammatory Responses ◽

Antibody Responses ◽

Host Defence ◽

System P ◽

Dying Cells ◽

The Complement System

The complement system consists of over 20 distinct proteins and is an essential component of the innate immune system. It is a major effector mechanism of host defence against infection and inflammatory responses, has an important role in the physiological removal of immune complexes and dying cells, and plays an accessory role in the induction of antibody responses....

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Proteins of the Innate Immune System Crystallize on Carbon Nanotubes but Are Not Activated

ACS Nano ◽

10.1021/nn102400w ◽

2011 ◽

Vol 5 (2) ◽

pp. 730-737 ◽

Cited By ~ 39

Author(s):

Wai Li Ling ◽

Adrienn Biro ◽

Isabelle Bally ◽

Pascale Tacnet ◽

Aurélien Deniaud ◽

...

Keyword(s):

Carbon Nanotubes ◽

Immune System ◽

Innate Immune System ◽

Innate Immune

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Biological effects of double-walled carbon nanotubes on the innate immune system: An in vitro study on THP-1 human monocytes

Toxicology ◽

10.1016/j.tox.2016.07.019 ◽

2016 ◽

Vol 365 ◽

pp. 1-8

Author(s):

Samir Dekali ◽

Christine Bachelet ◽

Séverine Maunoir-Regimbal ◽

Emmanuel Flahaut ◽

Jean-Claude Debouzy ◽

...

Keyword(s):

Carbon Nanotubes ◽

Immune System ◽

Innate Immune System ◽

Biological Effects ◽

In Vitro Study ◽

Innate Immune ◽

Human Monocytes ◽

Double Walled Carbon Nanotubes ◽

Walled Carbon Nanotubes

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Recognition of Carbon Nanotubes by the Human Innate Immune System

Carbon Nanotubes for Biomedical Applications ◽

10.1007/978-3-642-14802-6_10 ◽

2011 ◽

pp. 183-210 ◽

Cited By ~ 5

Author(s):

Malgorzata J. Rybak-Smith ◽

Kirsten M. Pondman ◽

Emmanuel Flahaut ◽

Carolina Salvador-Morales ◽

Robert B. Sim

Keyword(s):

Carbon Nanotubes ◽

Immune System ◽

Innate Immune System ◽

Innate Immune

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Complement Component C3: A Novel Biomarker Participating in the Pathogenesis of Non-alcoholic Fatty Liver Disease

Frontiers in Medicine ◽

10.3389/fmed.2021.653293 ◽

2021 ◽

Vol 8 ◽

Author(s):

Juqiang Han ◽

Xiang Zhang

Keyword(s):

Immune System ◽

Liver Disease ◽

Fatty Liver ◽

Complement System ◽

Innate Immune System ◽

Fatty Liver Disease ◽

Complement Component ◽

Innate Immune ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disorder worldwide. The pathological spectrum of NAFLD ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) that induces progressive liver cirrhosis and eventually hepatocellular carcinoma (HCC). However, the molecular mechanisms driving the transformation of NASH are obscure. There is a compelling need for understanding the pathogenic mechanisms of NASH, and thereby providing new insight into mechanism-based therapy. Currently, several studies reported that complement system, an innate immune system, played an important role in the pathogenesis of NAFLD, which was also proved by our recent study. Complement component 3 (C3), a protein of the innate immune system, plays a hub role in the complement system. Herein, we present a review on the role and molecular mechanism of C3 in NASH as well as its implication in NASH diagnosis and treatment.

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