Modular synthesis of glycopolymers with well-defined sugar units in the side chain via Ugi reaction and click chemistry: hetero vs. homo

2016 ◽  
Vol 7 (25) ◽  
pp. 4263-4271 ◽  
Author(s):  
Lulu Xue ◽  
Xinhong Xiong ◽  
Kui Chen ◽  
Yafei Luan ◽  
Gaojian Chen ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Ugi Reaction ◽  
Side Chain ◽  
Click Reactions ◽  
Modular Synthesis

Modularized glycopolymers were prepared via Ugi and click reactions, and used as models to investigate their binding abilities.

scholarly journals Organocatalytic Silicon-Free SuFEx reactions for modular synthesis of sulfonate esters and sulfonamides

2021 ◽  
Author(s):  
Muze Lin ◽  
JInyun Luo ◽  
Yu Xie ◽  
Guangfen Du ◽  
Zhihua Cai ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Click Chemistry ◽  
Natural Product ◽  
Secondary Amines ◽  
Mechanism Study ◽  
Click Reactions ◽  
Modular Synthesis ◽  
Rapid Construction ◽  
Primary And Secondary Amines ◽  
Brønsted Base

Sulfur(VI) fluoride exchange (SuFEx) click chemistry provides a powerful tool for rapid construction of modular connections. Here, we report a novel catalytic silicon-free SuFEx reaction with sulfonyl fluorides. Under the catalysis of 10 mol% N-heterocyclic carbene (NHC), a range of phenols and alcohols react with different sulfonyl fluorides to afford sulfonate esters in 49-99% yields. In addition, Under the relay catalysis of 10 mol% N-heterocyclic carbene and 10 mol% 1-hydroxybenzotriazole (HOBt), a variety of primary and secondary amines react with different sulfonyl fluorides to produce sulfonamides in 58%-99% yields. More than 140 sulfonylated products, including 17 natural product derivatives have been prepared through this method. Mechanism study showed that NHCs might act as a carbon-centered Brønsted base to catalyse the SuFEx click reactions via the formation of hydrogen bonding with phenols or alcohols.

Synthesis of a Cholesterol Side-Chain Triazole Analogue via ‘Click’ Chemistry

Synthesis ◽  
2015 ◽  
Vol 47 (18) ◽  
pp. 2826-2830 ◽  
Author(s):  
Matar Seck ◽  
Yagamare Fall ◽  
Insa Seck ◽  
Alioune Fall ◽  
Carmen Lago ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Side Chain

CuAAC click reactions for the design of multifunctional luminescent ruthenium complexes

2016 ◽  
Vol 45 (6) ◽  
pp. 2338-2351 ◽  
Author(s):  
Natalia Zabarska ◽  
Anne Stumper ◽  
Sven Rau
Keyword(s):  
Click Chemistry ◽  
Ruthenium Complexes ◽  
Click Reactions ◽  
Versatile Tool ◽  
Potential Applicability

CuAAC (Cu(i) catalyzed azide–alkyne cycloaddition) click chemistry has emerged as a versatile tool in the development of photoactive ruthenium complexes with multilateral potential applicability. Three general concepts for their synthesis and selected applications are discussed.

Synthesis and self-assembly behaviours of side-chain smectic thiol–ene polymers based on the polysiloxane backbone

2016 ◽  
Vol 4 (7) ◽  
pp. 1425-1440 ◽  
Author(s):  
Wenhuan Yao ◽  
Yanzi Gao ◽  
Xiao Yuan ◽  
Baofeng He ◽  
Haifeng Yu ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Click Chemistry ◽  
Self Assembly ◽  
Side Chain ◽  
Liquid Crystal Polymers ◽  
Different Types

A series of novel chiral polysiloxane side chain liquid crystal polymers (PSCLCPs) with two different types of LC phases and three self-assembly arrangements were successfully synthesized via thiol–ene click chemistry.

scholarly journals Orthogonal click reactions enable the synthesis of ECM-mimetic PEG hydrogels without multi-arm precursors

2018 ◽  
Vol 6 (30) ◽  
pp. 4929-4936 ◽  
Author(s):  
Faraz Jivan ◽  
Natalia Fabela ◽  
Zachary Davis ◽  
Daniel L. Alge
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Chemistry ◽  
Bioactive Peptides ◽  
Poly Ethylene Glycol ◽  
Click Reactions ◽  
Peg Hydrogels ◽  
Poly Ethylene

A two-step, click chemistry approach to create user-defined hydrogels consisting of poly(ethylene glycol) and bioactive peptides without the use of multi-arm precursors for tissue engineering.

scholarly journals Sequential nucleophilic “click” reactions for functional amphiphilic homopolymers

2019 ◽  
Vol 10 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Huan He ◽  
Bin Liu ◽  
Meizhe Wang ◽  
Richard W. Vachet ◽  
S. Thayumanavan
Keyword(s):  
Side Chain ◽  
Click Reactions ◽  
Amphiphilic Homopolymers

Sequential introduction of two side-chain functionalities is achieved with nucleophilic “click”.

scholarly journals Quantitative Analysis of Cu(I) Concentration in Click Chemistry — Biotinylation at Side Chain of Propargylglycine Using Click Chemistry under Heating Conditions —

Heterocycles ◽  
2012 ◽  
Vol 86 (1) ◽  
pp. 735 ◽  
Author(s):  
Makoto Hashimoto ◽  
Yui Ogasawara ◽  
Yuta Murai ◽  
Yasuko Sakihama ◽  
Yasuyuki Hashidoko
Keyword(s):  
Quantitative Analysis ◽  
Click Chemistry ◽  
Side Chain

scholarly journals Cofactor-specific covalent anchoring of cytochrome b562on a single-walled carbon nanotube by click chemistry

RSC Advances ◽  
2016 ◽  
Vol 6 (70) ◽  
pp. 65936-65940 ◽  
Author(s):  
Akira Onoda ◽  
Nozomu Inoue ◽  
Stéphane Campidelli ◽  
Takashi Hayashi
Keyword(s):  
Carbon Nanotube ◽  
Click Chemistry ◽  
Side Chain ◽  
Azide Group ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Redox Active ◽  
Covalently Linked

Redox-active cytochromeb562with a tethered azide group on the heme propionate side chain is covalently linked to an acetylene moiety introduced on the sidewall of a single-walled carbon nanotube by copper-catalyzed click chemistry.

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