Glutathione responsive polymers and their application in drug delivery systems

2017 ◽  
Vol 8 (1) ◽  
pp. 97-126 ◽  
Author(s):  
John F. Quinn ◽  
Michael R. Whittaker ◽  
Thomas P. Davis
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Research Interest ◽  
Drug Delivery Vehicles ◽  
Responsive Polymers ◽  
Delivery Vehicles ◽  
The Subject ◽  
Smart Drug ◽  
Smart Drug Delivery ◽  
Intense Research

Materials which respond to biological cues are the subject of intense research interest due to their possible application in smart drug delivery vehicles.

PUA/PSS multilayer coated CaCO3 microparticles as smart drug delivery vehicles

2013 ◽  
Vol 33 (7) ◽  
pp. 3745-3752 ◽  
Author(s):  
Chao Du ◽  
Jun Shi ◽  
Jin Shi ◽  
Li Zhang ◽  
Shaokui Cao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Hyaluronic Acid/Polylysine Composites for Local Drug Delivery: A Review

2020 ◽  
Vol 850 ◽  
pp. 213-218
Author(s):  
Elīza Tračuma ◽  
Dagnija Loca
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Local Drug Delivery ◽  
Gene Engineering ◽  
Drug Delivery Vehicles ◽  
Bilayer Films ◽  
Delivery Vehicles ◽  
Smart Drug

Site specific drug delivery systems (DDS) are usually developed to overcome the side effects of conventional ones (e.g. injections or oral ingestions), creating smart drug delivery vehicles characterized with greater efficiency, safety, predictable therapeutic response as well as controlled and prolonged drug release periods. DDS made of hyaluronic acid (HA) and poly-L-lysine (PLL) are promising candidates in the field of local drug delivery due to their high biocompatibility. Moreover, electrostatic attractions between negatively charged HA and positively charged PLL can be used to fabricate multilayer films, bilayer films and hydrogels, avoiding the application of toxic crosslinking agents. In this review, we report the preparation of HA/PLL composites exploiting their intrinsic properties, as well as developed composite application possibilities as controlled drug delivery systems in bone tissue, central nervous system and gene engineering.

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

Smart Drug Delivery Systems

Drug Delivery ◽  
2014 ◽  
pp. 265-316
Author(s):  
Eric P. Holowka ◽  
Sujata K. Bhatia
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery
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