Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 57580-57602 ◽  
Author(s):  
Neeta Thapliyal ◽  
Tirivashe E. Chiwunze ◽  
Rajshekhar Karpoormath ◽  
Rajendra N. Goyal ◽  
Harun Patel ◽  
...  
Keyword(s):  
Biological Samples ◽  
Critical Analysis ◽  
Pharmaceutical Formulations ◽  
Antimalarial Drugs ◽  
Research Progress ◽  
Electroanalytical Methods ◽  
Biological Matrices

The review focusses on the role of electroanalytical methods for determination of antimalarial drugs in biological matrices and pharmaceutical formulations with a critical analysis of published voltammetric and potentiometric methods.

ChemInform Abstract: Research Progress in Electroanalytical Techniques for Determination of Antimalarial Drugs in Pharmaceutical and Biological Samples

ChemInform ◽  
2016 ◽  
Vol 47 (35) ◽  
Author(s):  
Neeta Thapliyal ◽  
Tirivashe E. Chiwunze ◽  
Rajshekhar Karpoormath ◽  
Rajendra N. Goyal ◽  
Harun Patel ◽  
...  
Keyword(s):  
Biological Samples ◽  
Antimalarial Drugs ◽  
Research Progress

A Review of Voltammetric Methods for Determination of Dopamine Agonists

2020 ◽  
Vol 16 ◽  
Author(s):  
Fatma Ağin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Biological Samples ◽  
Dopamine Agonists ◽  
Modified Electrodes ◽  
Nerve Cells ◽  
Electroanalytical Methods ◽  
Voltammetry Methods ◽  
Voltammetric Methods

Background: Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early stages and in later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medicinal, clinical and pharmaceutical research. The voltammetry is one of the most commonly used electroanalytical methods. The aims of this review are to gather and discuss studies of voltammetric methods used in determination of dopamine agonists. Method: This review includes the use of various voltammetric methods for determination studies of dopamine agonists from pharmaceutical dosage forms and biological samples. These studies were examined in terms of used voltammetric method or methods, working electrode, buffer, pH and validation parameters. Results: Cabergoline, pramipexole, ropinirole have more studies, while bromocriptine and apomorphine have fewer studies in the literature. Differential pulse voltammetry and square wave voltammetry methods were the most applied methods for determination of dopamine agonist drugs from pharmaceuticals and biological samples. But, stripping, cyclic and lineer sweep voltammetry methods are less applied methods. In this studies, a lot of modified electrodes were developed and used to analyse of dopamine agonists. Conclusion: The voltammetric methods supply determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations without the necessity for the sample pre-treatment or time consuming extraction steps. Also the modified electrodes and validated voltammetric methods provide good stability, repeatability, reproducibility and high recovery for the analysis of the analyte.

scholarly journals Sensitive Determination of Terazosin in Pharmaceutical Formulations and Biological Samples by Ionic-Liquid Microextraction Prior to Spectrofluorimetry

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mohsen Zeeb ◽  
Mahdi Sadeghi
Keyword(s):  
Ionic Liquid ◽  
Ionic Strength ◽  
Biological Samples ◽  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Experimental Conditions ◽  
Relative Standard ◽  
Common Ion ◽  
Liquid Microextraction

An efficient and environmentally friendly sample preparation method based on the application of hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) as a microextraction solvent was proposed to preconcentrate terazosin. The performance of the microextraction method was improved by introducing a common ion of pyridinium IL into the sample solution. Due to the presence of the common ion, the solubility of IL significantly decreased. As a result, the phase separation successfully occurred even at high ionic strength, and the volume of the settled IL-phase was not influenced by variations in the ionic strength (up to 30% w/v). After preconcentration step, the enriched phase was introduced to the spectrofluorimeter for the determination of terazosin. The obtained results revealed that this system did not suffer from the limitations of that in conventional ionic-liquid microextraction. Under optimum experimental conditions, the proposed method provided a limit of detection (LOD) of 0.027 μg L−1and a relative standard deviation (R.S.D.) of 2.4%. The present method was successfully applied to terazosin determination in actual pharmaceutical formulations and biological samples. Considering the large variety of ionic liquids, the proposed microextraction method earns many merits, and will present a wide application in the future.

Enantiomeric Determination of Drugs in Pharmaceutical Formulations and Biological Samples by Electrokinetic Chromatography

2019 ◽  
Vol 50 (6) ◽  
pp. 554-584 ◽  
Author(s):  
Natalia Casado ◽  
Jesús Valimaña-Traverso ◽  
María Ángeles García ◽  
María Luisa Marina
Keyword(s):  
Biological Samples ◽  
Pharmaceutical Formulations ◽  
Electrokinetic Chromatography

Capillary Electrophoresis Methods for the Determination of Tramadol: A Review

2019 ◽  
Vol 25 (4) ◽  
pp. 278-286
Author(s):  
Anita Sarkany ◽  
Gabriel Hancu ◽  
Claudiu Drăguț ◽  
Adriana Modroiu ◽  
Enikő Barabás-Hajdu
Keyword(s):  
Capillary Electrophoresis ◽  
Opioid Analgesic ◽  
Cost Effective ◽  
Pharmaceutical Formulations ◽  
Racemic Mixture ◽  
Effective Solution ◽  
Complex Mechanism ◽  
Biological Matrices ◽  
Opiate Agonist

Tramadol is a widely used opioid analgesic frequently prescribed for treatment of moderate to severe, acute and chronic pain. It has a complex mechanism of action, acting both as a central opiate agonist and as a norepinephrine and serotonin reuptake inhibitor. It is a chiral substance, having two chiral centers in its structure and it is used in therapy as a racemic mixture of two of its enantiomers, (S,S)-tramadol and (R,R)-tramadol. In the last 25 years, several analytical procedures have been published in the literature for the achiral and chiral determination of tramadol from pharmaceutical formulations and biological matrices. Among these methods, capillary electrophoresis techniques have proved to be an efficient, reliable and cost-effective solution. The purpose of the present review is to provide a systematic survey to present and discuss the electrodriven methods available in the literature for the achiral and chiral analysis of tramadol.

Gold nanoparticles as a colorimetric probe for the determination of N-acetyl-l-cysteine in biological samples and pharmaceutical formulations

2015 ◽  
Vol 7 (4) ◽  
pp. 1478-1483 ◽  
Author(s):  
Saadat Rastegarzadeh ◽  
Fatemeh Hashemi
Keyword(s):  
Gold Nanoparticles ◽  
Ascorbic Acid ◽  
Biological Samples ◽  
Pharmaceutical Formulations ◽  
Reducing Agent ◽  
Spectrophotometric Detection ◽  
Colorimetric Probe

In this study, gold nanoparticles (AuNPs) have been synthesised using ascorbic acid as a reducing agent and employed in the design of an in situ colorimetric probe for the spectrophotometric detection of N-acetyl-l-cysteine (NAC).

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