Sample Pretreatment and Determination of Non Steroidal Anti-Inflammatory Drugs (NSAIDs) in Pharmaceutical Formulations and Biological Samples (Blood, Plasma, Erythrocytes) by HPLC-UV-MS and μ-HPLC

2005 ◽  
Vol 12 (5) ◽  
pp. 573-588
Author(s):  
Mohamed Sultan ◽  
Gunther Stecher ◽  
Wolfgang Stoggl ◽  
Rania Bakry ◽  
P. Zaborski ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Biological Samples ◽  
Sample Pretreatment ◽  
Pharmaceutical Formulations ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Extractive Spectrophotometric Determination of Some Nonsteroidal Anti-Inflammatory Drugs Using Methylene Blue

2013 ◽  
Vol 96 (4) ◽  
pp. 737-744 ◽  
Author(s):  
Michael E El-Kommos ◽  
Niveen A Mohamed ◽  
Ahmed F Abdel Hakiem
Keyword(s):  
Methylene Blue ◽  
Methylene Chloride ◽  
Diclofenac Sodium ◽  
Pharmaceutical Formulations ◽  
Eye Drops ◽  
Calibration Data ◽  
Pharmaceutical Dosage Forms ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract A simple, rapid, sensitive, and accurate extractive spectrophotometric method has been developed for the determination of seven nonsteroidal anti-inflammatory drugs (NSAIDs)—namely diclofenac sodium, ibuprofen, indomethacin, ketoprofen, ketorolac tromethamine, mefenamic acid, and naproxen—in pure forms as well as their pharmaceutical dosage forms (tablets, capsules, effervescent granules, syrups, oral drops, ampules, eye drops, gels, and suppositories). The method depends on the formation of an intensely colored ion-pair complex between the acidic drug and methylene blue in alkaline medium. The complex is stable and extractable into methylene chloride. All parameters were optimized. Beer-Lambert's law was obeyed in concentrations ranging from 0.04 to 9 μg/mL. Statistical analysis of the calibration data was carried out, and correlation coefficients were in the range from 0.9996 to 0.9998. The developed method was fully validated according to International Conference on Harmonization guidelines, and complied with U.S. Pharmacopeia guidelines. The proposed method was applied to the analysis of the investigated drugs in their pharmaceutical formulations, and good recoveries were obtained. The results obtained were compared with those of reported and official methods, and no significant differences were found with t- and F-tests. Interference effects of some compounds usually present in combination with NSAIDs were studied, and the tolerance limits of these compounds were determined.

Sequential Injection Magneto Chromatography Determination of Non-Steroidal Anti-Inflammatory Drugs in Pharmaceutical Formulations

2013 ◽  
Vol 46 (11) ◽  
pp. 1732-1742 ◽  
Author(s):  
Israel S. Ibarra ◽  
Jose A. Rodríguez ◽  
Karina Aguilar-Arteaga ◽  
Elizabeth Contreras-Lopez ◽  
Enrique Barrado
Keyword(s):  
Pharmaceutical Formulations ◽  
Sequential Injection ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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