Folic acid targeted pH-responsive amphiphilic polymer nanoparticles conjugated with near infrared fluorescence probe for imaging-guided drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 40312-40322 ◽  
Author(s):  
Liyi Fu ◽  
Le Liu ◽  
Zheng Ruan ◽  
Houbing Zhang ◽  
Lifeng Yan
Keyword(s):  
Folic Acid ◽  
Ring Opening ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Click Reaction ◽  
Raft Polymerization ◽  
Ring Opening Polymerization ◽  
Amphiphilic Polymer ◽  
Polymer Nanoparticles ◽  
Ph Responsive

A novel folic acid targeted pH-responsive amphiphilic polymer conjugated with near infrared (NIR) probe has been synthesized by the combination of RAFT polymerization, ring-opening polymerization of N-carboxy anhydride (NCA) and click reaction.

One-pot synthesis of PLA-b-PHEA via sequential ROP and RAFT polymerizations

2017 ◽  
Vol 8 (39) ◽  
pp. 6086-6098 ◽  
Author(s):  
Ilknur Yildirim ◽  
Pelin Sungur ◽  
Anna C. Crecelius-Vitz ◽  
Turgay Yildirim ◽  
Diana Kalden ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ring Opening ◽  
Raft Polymerization ◽  
Ring Opening Polymerization ◽  
One Pot ◽  
One Pot Synthesis

A block copolymer library of polylactide and poly(2-hydroxyethyl acrylate) was prepared via sequential ring opening polymerization and RAFT polymerization in a one-pot approach.

Double-networks based on pH-responsive, amphiphilic “core-first” star first polymer conetworks prepared by sequential RAFT polymerization

2017 ◽  
Vol 8 (1) ◽  
pp. 245-259 ◽  
Author(s):  
Elina N. Kitiri ◽  
Costas S. Patrickios ◽  
Chrysovalantis Voutouri ◽  
Triantafyllos Stylianopoulos ◽  
Ingo Hoffmann ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Raft Polymerization ◽  
Amphiphilic Polymer ◽  
Ph Responsive ◽  
Nanophase Separation ◽  
Double Networks

Double-networks based on amphiphilic polymer conetworks synthesized using RAFT polymerization were prepared, exhibiting pH-responsiveness, nanophase separation and enhanced mechanical properties.

Synthesis of Zwitterionic Chimeric Polymersomes for Efficient Protein Loading and Intracellular Delivery

2021 ◽  
Author(s):  
bingbing zhao ◽  
Yuting Yan ◽  
Junmei Zhang ◽  
Enping Chen ◽  
Ke Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Ring Opening Polymerization ◽  
H Nmr ◽  
Protein Loading ◽  
Reversible Addition

A novel zwitterionic triblock copolymer of poly(dimethylamino carbonate)-polycaprolactone-poly((2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium) [PAC(DMA)-PCL-PMDMSA] was designed and synthesized via sequential ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization successively. The 1H NMR and...

Synthesis of miktoarm star-shaped and inverse star-block copolymers by a combination of ring-opening polymerization and click chemistry

e-Polymers ◽  
2018 ◽  
Vol 18 (6) ◽  
pp. 559-568 ◽  
Author(s):  
Xiaoqi Yan ◽  
Jianbo Li ◽  
Tianbin Ren
Keyword(s):  
Block Copolymer ◽  
Ring Opening ◽  
Click Reaction ◽  
Ring Opening Polymerization ◽  
Structure And Properties ◽  
Star Block Copolymer ◽  
Ft Ir ◽  
Miktoarm Star ◽  
Star Block Copolymers ◽  
Ft Ir Spectroscopy

AbstractBased on the combination of the “arm-first” and “core-first” strategies, the miktoarm star-shaped copolymer PLLA2PCL2 and the inverse star-block copolymer (PCL-b-PLLA)2-core-(PCL-b-PLLA)2 were designed and synthesized by the combination of ring-opening polymerization (ROP) and a click reaction. The miktoarm star-shaped copolymer PLLA2PCL2 was synthesized by a click reaction of an azido macroinitiator PLLA2(N3)2 and HC≡C-PCL. The inverse star-block copolymer (PCL-b-PLLA)2-core-(PCL-b-PLLA)2 was synthesized by a click reaction of an azido macroinitiator (PCL-b-PLLA)2(N3)2 and HC≡C-PCL-b-PLLA. The structures of these star polymers were confirmed by nuclear magnetic resonance (NMR), Fourier-transform infrared (FT-IR) spectroscopy and gel permeation chromatograph (GPC). The inverse star-block copolymer could be used to study the potential relationship between polymer structure and properties, which has a unique structure and good crystallization properties.

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