Rapid single-cell detection and identification of pathogens by using surface-enhanced Raman spectroscopy

The Analyst ◽  
2017 ◽  
Vol 142 (10) ◽  
pp. 1782-1789 ◽  
Author(s):  
N. E. Dina ◽  
H. Zhou ◽  
A. Colniţă ◽  
N. Leopold ◽  
T. Szoke-Nagy ◽  
...  

For the successful treatment of infections, real-time analysis and enhanced multiplex capacity, sensitivity and cost-effectiveness of the developed detection method are critical.

2019 ◽  
Vol 10 ◽  
pp. 1048-1055 ◽  
Author(s):  
Malwina Liszewska ◽  
Bogusław Budner ◽  
Małgorzata Norek ◽  
Bartłomiej J Jankiewicz ◽  
Piotr Nyga

Surface-enhanced Raman spectroscopy (SERS) is a very promising analytical technique for the detection and identification of trace amounts of analytes. Among the many substrates used in SERS of great interest are nanostructures fabricated using physical methods, such as semicontinuous metal films obtained via electron beam physical vapor deposition. In these studies, we investigate the influence of morphology of semicontinuous silver films on their SERS properties. The morphologies studied ranged from isolated particles through percolated films to almost continuous films. We found that films below the percolation threshold (transition from dielectric-like to metal-like) made of isolated silver structures provided the largest SERS enhancement of 4-aminothiophenol (4-ATP) analyte signals. The substrate closest to the percolation threshold has the SERS signal about four times lower than the highest signal sample.


2012 ◽  
Vol 234 (6) ◽  
pp. 1091-1098 ◽  
Author(s):  
Yunfei Xie ◽  
Godelieve Mukamurezi ◽  
Yingying Sun ◽  
Heya Wang ◽  
He Qian ◽  
...  

2013 ◽  
Vol 85 (5) ◽  
pp. 2630-2637 ◽  
Author(s):  
Jiajie Xu ◽  
Jeffrey W. Turner ◽  
Matthew Idso ◽  
Stanley V. Biryukov ◽  
Laurel Rognstad ◽  
...  

2020 ◽  
Vol 8 (16) ◽  
pp. 3316-3326 ◽  
Author(s):  
Jie Lin ◽  
Jianping Zheng ◽  
Aiguo Wu

Circulating tumor cells (CTCs) are circulating cancer cells that shed from tumor tissue into blood vessels and circulate in the blood to invade other organs, which results in fatal metastases. Surface-enhanced Raman scattering (SERS) has great potentials in CTCs detection.


2017 ◽  
Vol 37 (9) ◽  
pp. 0930001 ◽  
Author(s):  
房晓倩 Fang Xiaoqian ◽  
彭彦昆 Peng Yankun ◽  
李永玉 Li Yongyu ◽  
王 凡 Wang Fan ◽  
卜晓朴 Bu Xiaopu ◽  
...  

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