An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice

2018 ◽  
Vol 9 (1) ◽  
pp. 636-642 ◽  
Author(s):  
Dafne García-Mateos ◽  
Rocío García-Villalba ◽  
Jon A. Otero ◽  
José A. Marañón ◽  
Juan C. Espín ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Knockout Mice ◽  
Flaxseed Lignans

The ABCG2 transporter affects the tissue distribution of lignans and their microbial-derived enterolignans after a repeated flaxseed administration.

Involvement of Breast Cancer Resistance Protein (BCRP1/ABCG2) in the Bioavailability and Tissue Distribution oftrans-Resveratrol in Knockout Mice

2010 ◽  
Vol 58 (7) ◽  
pp. 4523-4528 ◽  
Author(s):  
Irene Alfaras ◽  
Míriam Pérez ◽  
Maria Emília Juan ◽  
Gracia Merino ◽  
Julio Gabriel Prieto ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tissue Distribution ◽  
Knockout Mice ◽  
Breast Cancer Resistance Protein ◽  
Cancer Resistance ◽  
Resistance Protein

The complexity of tetraspanins

2011 ◽  
Vol 39 (2) ◽  
pp. 501-505 ◽  
Author(s):  
Eric Rubinstein
Keyword(s):  
Immune Response ◽  
Tissue Distribution ◽  
Human Genome ◽  
Knockout Mice ◽  
Molecular Interaction ◽  
Normal Function ◽  
Surface Proteins ◽  
Genetic Studies ◽  
New Information ◽  
Membrane Compartmentalization

Tetraspanins compose a family of structurally related molecules with four transmembrane domains. A total of 33 tetraspanins are present in the human genome, and tetraspanins are also found in plants and certain fungi. A well-known property of tetraspanins is their ability to interact with one another and many other surface proteins, which led to the suggestion that they organize a network of molecular interaction referred to as the ‘tetraspanin web’, and that they play a role in membrane compartmentalization. Recent studies of the dynamics of these molecules provided important new information that helped refining the models of this ‘web’. Several genetic studies in mammals and invertebrates have demonstrated key physiological roles for some of the tetraspanins, in particular in immune response, sperm–egg fusion, photoreceptor function and the normal function of certain epitheliums or vascular development. However, in several examples, the phenotypes of tetraspanin-knockout mice are relatively mild or restricted to a particular organ, despite a wide tissue distribution.

Heat stable toxin of E. coli (STa) stimulates duodenal mucosal bicarbonate secretion in cystic fibrosis knockout mice

2001 ◽  
Vol 120 (5) ◽  
pp. A137-A137
Author(s):  
D CHILDS ◽  
D CROMBIE ◽  
V PRATHA ◽  
Z SELLERS ◽  
D HOGAN ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Knockout Mice ◽  
Bicarbonate Secretion ◽  
E Coli ◽  
Heat Stable

Sa1495 LEPTIN AUGMENTS BILIARY HYPERPLASIA AND HEPATIC FIBROSIS IN MDR2-KNOCKOUT MICE

2020 ◽  
Vol 158 (6) ◽  
pp. S-1310
Author(s):  
Rebekah John ◽  
Anca D. Petrescu ◽  
Stephanie Grant ◽  
Elaina Williams ◽  
Sharon DeMorrow
Keyword(s):  
Hepatic Fibrosis ◽  
Knockout Mice

Abstract #219: Evidence of Insulitis in Signal Transducer and Activator of Transcription 5 (Stat5) Knockout Mice

2017 ◽  
Vol 23 ◽  
pp. 39
Author(s):  
Aili Guo ◽  
Nigel Daniels ◽  
Craig Nunemaker ◽  
Samantha J. Shaw ◽  
Karen Coschigano
Keyword(s):  
Knockout Mice ◽  
Signal Transducer

Xpa and Xpa/p53 +/- Knockout Mice: Overview of Available Data

2001 ◽  
Vol 29 (5) ◽  
pp. 117-127 ◽  
Author(s):  
Coen F. van Kreijl ◽  
Peter A. McAnulty ◽  
Rudolf B. Beems ◽  
An Vynckier ◽  
Harry van Steeg ◽  
...  
Keyword(s):  
Knockout Mice
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