Decoding the regulatory mechanism of glucose and insulin induced phosphatidylinositol 3,4,5-trisphosphate dynamics in β-cells

2017 ◽  
Vol 13 (8) ◽  
pp. 1512-1523
Author(s):  
Tagari Samanta ◽  
Peeyush Sharma ◽  
Dwijendra Kukri ◽  
Sandip Kar
Keyword(s):  
Mathematical Modeling ◽  
Regulatory Mechanism ◽  
Β Cells ◽  
Mechanistic Insight ◽  
Synergistic Activation ◽  
Insight Into ◽  
Modeling Study

Mathematical modeling study provides mechanistic insight into the glucose and insulin mediated synergistic activation of PIP3in MIN6 β-cells.

scholarly journals Cdc42 activity is essential for the interplay between cAMP/PKA pathway and CatSper function

2020 ◽  
Author(s):  
Guillermina M. Luque ◽  
Xinran Xu ◽  
Ana Romarowski ◽  
María G. Gervasi ◽  
Gerardo Orta ◽  
...  
Keyword(s):  
Regulatory Mechanism ◽  
Camp Production ◽  
Mammalian Sperm ◽  
Mechanistic Insight ◽  
Complex Regulation ◽  
Principal Piece ◽  
Pka Pathway ◽  
Dependent Pathway ◽  
Insight Into ◽  
Stimulation Of

AbstractSperm acquire the ability to fertilize in a process called capacitation and undergo hyperactivation, a change in the motility pattern, which depends on Ca2+ transport by CatSper channels. CatSper is essential for fertilization and it is subjected to a complex regulation that is not fully understood. Here, we report that similar to CatSper, Cdc42 distribution in the principal piece is confined to four linear domains and this localization is disrupted in CatSper1-null sperm. Cdc42 inhibition impaired CatSper activity and other Ca2+-dependent downstream events resulting in a severe compromise of the sperm fertilizing potential. We also demonstrate that Cdc42 is essential for CatSper function by modulating cAMP production by sAC, providing a new regulatory mechanism for the stimulation of CatSper by the cAMP/PKA-dependent pathway. These results reveal a broad mechanistic insight into the regulation of Ca2+ in mammalian sperm, a matter of critical importance in male infertility as well as in contraception.

scholarly journals Mechanistic insight into B(C6F5)3 catalyzed imine reduction with PhSiH3 under stoichiometric water conditions

RSC Advances ◽  
2021 ◽  
Vol 11 (34) ◽  
pp. 20961-20969
Author(s):  
Yunqing He ◽  
Wanli Nie ◽  
Ying Xue ◽  
Qishan Hu
Keyword(s):  
Mechanistic Insight ◽  
Excess Water ◽  
Water Conditions ◽  
Imine Reduction ◽  
Water Amount ◽  
Insight Into

Hydrosilylation or amination products? It depends on water amount and nucleophiles like excess water or produced/added amines.

scholarly journals Mechanistic insight into the fluorescence activity of forensic fingerprinting reagents

2021 ◽  
Vol 154 (12) ◽  
pp. 124313
Author(s):  
L. M. Hunnisett ◽  
P. F. Kelly ◽  
S. Bleay ◽  
F. Plasser ◽  
R. King ◽  
...  
Keyword(s):  
Mechanistic Insight ◽  
Insight Into
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