An efficient catalyst-free one-pot synthesis of primary amides from the aldehydes of the Baylis–Hillman reaction

2017 ◽  
Vol 41 (17) ◽  
pp. 9203-9209 ◽  
Author(s):  
Thatikonda Narendar Reddy ◽  
Bikshapathi Raktani ◽  
Ramesh Perla ◽  
Mettu Ravinder ◽  
Jayathirtha Rao Vaidya ◽  
...  
Keyword(s):  
Efficient Method ◽  
One Pot ◽  
Efficient Catalyst ◽  
Free Condition ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Methanol System

Herein, a facile and efficient method for the preparation of allyl amides from the aldehydes of Baylis–Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition

2014 ◽  
Vol 52 (4) ◽  
pp. 1253-1259 ◽  
Author(s):  
Subrahmanya Ishwar Bhat ◽  
U. K. Das ◽  
Darshak R. Trivedi
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Free Condition ◽  
Catalyst Free ◽  
One Pot Synthesis

DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines

2017 ◽  
Vol 72 (5) ◽  
pp. 361-368 ◽  
Author(s):  
Esma Lamera ◽  
Sofiane Bouacida ◽  
Hocine Merazig ◽  
Aissa Chibani ◽  
Marc Le Borgne ◽  
...  
Keyword(s):  
Environmental Pollution ◽  
Efficient Method ◽  
Toxic Metals ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
Efficient Catalyst ◽  
One Pot Synthesis ◽  
The One ◽  
The Cost ◽  
Work Up

AbstractA new, convenient, and efficient method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is developed starting from phthalhydrazide, aromatic aldehydes, and malononitrile using 4-N,N-dimethylaminopyridin as catalyst. This modified route provides much higher yields and a simple work-up procedure of products. Also this methodology is of interest due to the use of ethanol as a solvent without use of any toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution.

Synthesis of new chiral N-alkyl Betti-base ligands via one-pot three component strategy

2021 ◽  
Vol 10 ◽  
Author(s):  
Siva Ganesh ◽  
Kondabatini Sarika ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Asymmetric Reactions ◽  
Chiral Ligands ◽  
Chiral Auxiliaries ◽  
Chromatographic Purification ◽  
One Pot ◽  
Asymmetric Transformations ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Betti Base

Background: Betti base derivatives were employed as chiral ligands or as chiral auxiliaries in asymmetric transformations. In particular, N-alkyl Betti base derivatives are gaining importance as excellent ligands in asymmetric reactions. However there is no appropriate method exists for regioselective N-alkylation of Betti base. Therefore there is an urgent need to develop a new protocol for the regioselective N-alkylation of chiral Betti-base. Methods: An efficient method has been developed for one-pot synthesis of chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles under catalyst free conditions. Results: The chiral N-alkyl Betti-base ligands were obtained in good yields with excellent enantioselectivities. This method is a rapid, clean and does not require catalyst and chromatographic purification. Conclusion: We have developed an efficient one-pot three component strategy for the synthesis of new chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles in the absence of catalyst.

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