DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines
2017 ◽
Vol 72
(5)
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pp. 361-368
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AbstractA new, convenient, and efficient method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is developed starting from phthalhydrazide, aromatic aldehydes, and malononitrile using 4-N,N-dimethylaminopyridin as catalyst. This modified route provides much higher yields and a simple work-up procedure of products. Also this methodology is of interest due to the use of ethanol as a solvent without use of any toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution.
2011 ◽
Vol 76
(4)
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pp. 235-241
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